Adamantinoma of the Tibia: A Case Report

Abstract

Introduction:Adamantinoma is a bone tumor which is commonly showed in mandible. Its occurrence in long bones constitutes a rare affection and a difficult histological diagnosis This rare malignant tumor of mesenchymal and epithelial origin was discovered in the tibia of a male patient.Case Report:The authors report a case of adamantinoma of the tibia in a 36- years old. He presented with slowly progressing leg swelling that evolved over 2 years without significant clinical manifestation. Complementary examination and investigation did not help in differential diagnosis and confirmation was only possible after histological examination. There was increase in size of lesion with increased pain and patie3nt presented with pathological fracture. Local extension of the tumor indicated an amputation of leg. The histological exam of the amputation specimen confirmed the results of the initial biopsy by showing cells tumorales in favour of an adamantinoma. After a good medium-term follow up, the patient died secondary to lung metastases. The authors discuss their method of diagnosis and therapeutics in front of such tumor.Conclusion:Adamantinoma is characterized by a slow clinical development marked by the prevalence of lung metastases and local recurrences. After the diagnosis, there must be a complete and sufficient surgery to avoid a local recurrence or metastasis.

Adamantinoma filling the medullary space of the tibia: A case report

“…On histology, this form is dominated by basophil and tubular tumor cells. The other is the differentiated form, characterized by the presence of small isolated epithelial cells and multifocal fibrous dysplasia of bone in the cortex [1]. Our case fits the description of the classical form.…”

“…Anterior arch deformity of tibia is common. According to Desai et al, location in the tibia with intracortical development are 2 diagnostic indicators for adamantinoma [1]. However, in a series of 22 patients analyzed by Vander Woude [7], 60% of the tumors had discontinuous or more obvious bone marrow extensions, while only 40% were located in cortical bone.…”

“…Adamantinoma is characterized by a slow clinical progression with lung metastases and local recurrences over time. Hence, complete and sufficient surgery is usually performed to avoid local recurrence or metastasis after diagnosis of solitary foci [1]. Radiation and chemotherapy have not proven useful for the treatment of adamantinoma.…”

“…It is a rare low-grade primary neoplasm of the bone that originates from epithelial cells arranged in islands of fibers and proliferating fibroblastic medullary tissue. Adamantinoma often manifests as local recurrences and metastasis to the lung [1]. This tumor has not previously been reported as an isolated lesion filling the medullary space of the tibia.…”

3D-Printed Prosthesis Replacement for Limb Salvage after Radical Resection of an Ameloblastoma in the Tibia with 1 Year of Follow Up: A Case Report

“…Ameloblastoma occurs rarely in long bones and is slightly more common in the tibia 1. Most reports comprise individual cases, among which the treatment methods have differed 2345678. Since 1993, many scholars have used customized tibia prostheses to reconstruct limbs after tumor resection 91011121314.…”