Adamantane acid esters with alkoxyaryl alcohols: Synthesis, antiproliferative activity, and influence on microtubule network of tumor cells

Synthesis, in vitro cytotoxic and apoptotic effects, and molecular docking study of novel adamantane derivatives

“…However, homologs of 2-alkyl/aryl-substituted 4-thiazolidinones, namely spirothiazolidinones, are one of the most studied heterocyclic systems that show a wide range of biological activities such as antibacterial, [29,30] anticancer, [31,32] antifungal, [33] and antiviral activities. [34] In light of recent studies about the antitumor, antiproliferative, or anticancer effects of compounds bearing adamantane ring, [35][36][37][38][39][40] our aim is to synthesize several novel spirothiazolidinone compounds F I G U R E 1 Some drug molecules containing the adamantane ring bearing adamantane ring (Scheme 1). The structures of all obtained products were elucidated by spectroscopic methods and were screened for their in vitro cytotoxic activity against HepG2, PC-3, A549, and NIH/3T3 cell lines.…”