Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

Sadeghnejad, Alireza; Ohar, Jill A.; Zheng, S. Lilly; Sterling, David A.; Hawkins, Gregory A.; Meyers, Deborah A.; Bleecker, Eugene R.

doi:10.1186/1465-9921-10-21

Cited by 54 publications

(50 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SNPs in the ADAM-33 gene have been strongly associated with asthma, and there is some suggestion that such SNPs are also associated with COPD [97][98][99]. GOSSELINK et al [51] could not find any differences in ADAM-33 gene expression in the parenchyma in the various GOLD stages, although there were significant decreases in expression levels in the airways with increasing functional deficits.…”

Section: Series: Mmps In Lung Health and Diseasementioning

confidence: 86%

Matrix metalloproteinases in COPD

Churg

Zhou²,

Wright³

2011

European Respiratory Journal

237

116

View full text Add to dashboard Cite

There is considerable evidence that matrix metalloproteinases (MMPs) are up-and/or downregulated in chronic obstructive pulmonary disease (COPD), particularly in emphysema, in which they probably participate in proteolytic attack on the alveolar wall matrix. Recent data suggest that MMPs also have major roles in driving inflammation or shutting it down, as well as modifying the release of fibrogenic growth factors, processes that are important in the genesis of the various lesions of COPD. In cigarette smoke-induced animal models of emphysema, MMP-12 appears to play a consistent and important role, whereas the data for other MMPs are difficult to interpret. In human lungs, evidence for a role for MMPs is more tenuous and there are numerous contradictions in the literature. Little is known about the effects of MMPs in small airway remodelling, smokeinduced pulmonary hypertension and chronic bronchitis, but MMP-12 participates in experimental small airway modelling. To date, the accumulated data suggest that selective inhibition of MMP-12 might be a viable therapy for emphysema and small airway remodelling, but subtle differences in the functions of MMP-12 in animals and humans mandate caution with this approach. Whether inhibition of other MMPs might be useful is unclear.

show abstract

Section: Series: Mmps In Lung Health and Diseasementioning

confidence: 86%

Matrix metalloproteinases in COPD

Churg

Zhou²,

Wright³

2011

European Respiratory Journal

237

116

View full text Add to dashboard Cite

show abstract

“…Various previous studies have reported that ADAM33 is a positively cloned gene for asthma (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). Thus, it is necessary to study the association of ADAM33 and prevalence of asthma in different populations, particularly in those living in special geographical environments, such as China's Li population.…”

Section: Discussionmentioning

confidence: 99%

“…The following are characteristic of ADAM33: Protease activity, a domain structure composed of a signal sequence, a prodomain, a metalloprotease domain, a transmembrane domain, a cysteine-rich domain, a disintegrin domain and a cytoplasmic domain (6). At present, >100 single-nucleotide polymorphisms (SNPs) of the ADAM33 gene have been reported to be associated with asthma or BHR (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). However, the data that demonstrate the association of ADAM33 SNPs with asthma were obtained from individuals living in mainland areas, who were predominantly Caucasian and Asian (10,11,(19)(20)(21) (22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

et al. 2017

View full text Add to dashboard Cite

Abstract. A disintegrin and metalloprotease 33 (ADAM33)is an asthma susceptibility gene that has been proven to be present in certain human populations. The Li population is a minority ethnic group, most of whom maintain a distinctive lifestyle on Hainan Island in southern China. To the best of our knowledge, no previous study has established whether ADAM33 polymorphisms are associated with asthma in the Li population. Therefore, the ADAM33 polymorphisms in a Li population were investigated in the present study. A total of 150 asthma patients and 100 healthy subjects were enrolled in the present study, and their DNA samples were evaluated to analyze eight single-nucleotide polymorphisms (SNPs) on the ADAM33 gene. Asthma patients were subcategorized into low and high severity groups, and their SNP data were compared with the data of the control subjects. Single-marker and haplotype association was analyzed to demonstrate the association between ADAM33 SNPs and asthma using multiple genetic statistic tests. The results indicated significant differences in allele frequencies at the SNPs rs44707/T2 (P=0.008), rs2787094/V4 (P=0.028) and rs2280089/T+1 (P=0.021) between asthma patients and control subjects. The SNP rs44707/T2 was also found to be associated with the high severity group (P=0.024), although SNPs rs2787094/V4 were associated with the low severity group (P=0.019). Two haplotypes, GGAGAGT and GAAGGGT, were significantly associated with asthma (P=0.003 and 0.008, respectively). To the best of our knowledge, this is the first time that SNP rs2280089/T+1 has been reported to be associated with asthma in an Asian population. These data confirm that ADAM33 polymorphisms are associated with asthma susceptibility in the Li population and confirm the uniqueness of the Li minority population within China. IntroductionAsthma is a chronic inflammatory disease of the airway. More than 100 million people across the globe suffer from this disorder (Global strategy for asthma management and prevention; http://www.ginasthma.org). Airway inflammation, bronchial hyperresponsiveness (BHR), and reversible airflow obstruction are the primary characteristics of asthma. Among these, airway inflammation is most closely associated with the clinical symptoms. Currently, genetic and environmental factors have been found to be involved in the generation of asthma pathologies. Thus, the potential contribution of genetic factors is considered to be an interesting area of clinical and basic research.The A disintegrin and metalloprotease 33 (ADAM33) gene is an asthma susceptibility gene, which was first reported by Van Eerdewegh et al (1). The ADAM33 gene is mapped to the short arm of chromosome 20p13 in the human genome, and is predominantly expressed in airway smooth-muscle cells and lung fibroblast cells, but not in epithelial cells, T cells or inflammatory leukocytes (2-6). ADAM proteins are involved in cell-cell and cell-matrix interactions (5), cell migration (2,3), cell-cell adhesion and signal transduction (4). The following are c...

show abstract

“…Many candidate genes, including IL-6 (Broekhuizen et al, 2005;Danilko et al, 2007;Córdoba-Lanús et al, 2008;He et al, 2009), IL-8 (Shen et al, 2008, tumor necrosis factor (Küçükaycan et al, 2002), disintegrin and metalloprotease 33 (Sadeghnejad et al, 2009;Wang et al, 2009;Xiao et al, 2011), and beta 2-adrenoceptor (Hegab et al, 2004;Matheson et al, 2006) have been reported to be involved in COPD susceptibility. IL-6 is a potential mediator of inflammation in COPD, and has been shown to be increased in serum, exhaled breath condensate, and sputum during stable conditions and exacerbation, predicting a faster decline in forced expiratory volume in one second (Agustı et al, 2003;Donaldson et al, 2005;He et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

“…Polymorphic variants have been currently found in many cytokine genes and are associated with the development of a variety of diseases (Brogger et al, 2006;Galiè et al, 2009;Gingo et al, 2008;Pillai et al, 2009;Sadeghnejad et al, 2009). Interleukin-6 (IL-6) is one such cytokine, and is located on chromosome 7p21 and functions as a pleiotropic pro-inflammatory and immunomodulatory cytokine.…”

Section: Introductionmentioning

confidence: 99%

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Xie¹,

Ke²,

Yh³

et al. 2015

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Association studies of interleukin-6 (IL-6) -174G>C polymorphism and chronic obstructive pulmonary disease (COPD) have yielded inconsistent results, possibly because single studies often lack sufficient statistical power. A comprehensive search was performed in the PubMed, Embase, Elsevier, Web of Science databases, Wanfang, and the Chinese National Knowledge Infrastructure (CNKI) databases for published studies investigating the associations between IL-6 -174G>C polymorphism and COPD. Odds ratios (OR) and 95% confidence intervals (95%CI) were used to assess the possible associations. Seven studies with a total of 2701 subjects were included in this meta-analysis. A significantly increased risk was detected in the C allele of the IL-6 -174G>C in Caucasians (C vs G: OR = 1.16, 95%CI = 1.03-1.30; CC+GC vs GG: OR = 1.21, 95%CI = 1.02-1.42; CC vs GG: OR = 1.32, 95%CI = 1.03-1.70). This meta-analysis suggests that the C allele of the IL-6 -174G>C might act as a COPD risk factor in 8517 IL-6 polymorphism and COPD risk ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (3): 8516-8525 (2015) Caucasians. Further well-designed case-control studies with larger sample sizes are needed to confirm these conclusions.

show abstract

Adam33 polymorphisms are associated with COPD and lung function in long-term tobacco smokers

Cited by 54 publications

References 28 publications

Matrix metalloproteinases in COPD

Matrix metalloproteinases in COPD

ADAM33 gene polymorphisms identified to be associated with asthma in a Chinese Li population

Interleukin-6 gene -174G>C polymorphism and chronic obstructive pulmonary disease risk: a meta-analysis

Contact Info

Product

Resources

About