ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells

Sun, Yaping; Wang, Ying‐Ming; Zhang, Jing; Ji, Tao; Wang, Chen; Jing, Naihe; Wu, Chaoqun; Deng, Kejing; Qiao, Shan

doi:10.1007/s11064-007-9293-1

Cited by 13 publications

(16 citation statements)

References 29 publications

(34 reference statements)

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“…ADAM23-deficient mice show tremor and strict ataxia and die within two weeks after birth [14]. Like the previous studies [62,63], we found that ADAM23 is expressed in two forms and its expression is regulated at different developmental stages (Fig. 8).…”

Section: Adam23supporting

confidence: 85%

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Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Markus

Yan

Rolfs

et al. 2011

Cellular and Molecular Biology Letters

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Abstract:The ADAM (A Disintegrin and Metalloprotease) family of transmembrane proteins plays important roles in embryogenesis and tissue formation based on their multiple functional domains. In the present study, for the first time, the expression patterns of the premature and the active forms of six members of the ADAM proteins -ADAM9, ADAM10, ADAM12, ADAM17, ADAM22 and ADAM23 -in distinct parts of the developing chicken brain were investigated by quantitative Western blot analysis from embryonic incubation day (E) 10 to E20. The results show that the premature and the active forms of various ADAM proteins are spatiotemporally regulated in different parts of the brain during development, suggesting that the ADAMs play a very important role during embryonic development.

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Section: Adam23supporting

confidence: 85%

“…ADAM23 appears during the differentiation of P19 cells and is involved in the formation of neurites, where ADAM23 is asymmetrically distributed [62]. ADAM23-deficient mice show tremor and strict ataxia and die within two weeks after birth [14].…”

Section: Adam23mentioning

confidence: 99%

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Markus

Yan

Rolfs

et al. 2011

Cellular and Molecular Biology Letters

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“…ADAM23 is expressed predominately as a membrane-bound receptor that localizes to sites of intercellular contact [6]. Studies have further reported that ADAM23 plays an important role in CNS processes [6,8], with loss in function leading to tremors and epileptic episodes [9]. Studies have further reported that ADAM23 plays an important role in CNS processes [6,8], with loss in function leading to tremors and epileptic episodes [9].…”

Section: Introductionmentioning

confidence: 99%

Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor

Elizondo

Andargie

Marshall

et al. 2016

Journal of Leukocyte Biology

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ADAM23 is a member of the brain macrophage-derived chemokine family. Structural homology of ADAM proteins suggests their function as integrin receptors. Previous studies have linked ADAM23 as a dominant contributor to brain development and cancer metastasis. The present studies now show that ADAM23 expression on DCs partially governs antigen-presentation capacities to responder CD4 T cells. With the use of RNAi approaches, knockdown of ADAM23 in murine BMDCs resulted in impaired T cell activation, proliferation, and cytokine production. Knockdown did not alter the maturation profile of DCs (i.e., costimulatory molecule expression or production of proinflammatory cytokines) but markedly impaired cognate T cell responses. There was a significant decrease in antigen-specific clonal expansion coupled with a global decrease in Th cytokine production. Impaired early activation and proliferation did not alter/skew the balance of Th polarization but significantly depressed total levels of IL-2, IFN-γ, IL-4, and IL-17 cytokine production in CD4 T cells primed by ADAM23 knockdown versus control DCs. Finally, neutralizing antibodies targeting the α(v)β(3) integrin receptors resulted in similar phenotypes of impaired CD4 T cell responses. Taken together, these studies show a novel role of ADAM23 in governing DC antigen presentation to cognate CD4 T cells.

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“…ADAM10 sheds ephrinA 2 inducing ephrinA2-mediated axon repulsion (Hattori, 2000) and ADAM10 is required for the formation of the optic projection to the tectum (Chen at al., 2007). Finally, ADAM23 is involved in neuronal differentiation of P19 cells (Sun et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Expression of seven members of the ADAM family in developing chicken spinal cord

Lin

Yan

Markus

et al. 2010

Developmental Dynamics

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The expression patterns of seven members of the ADAM (a disintegrin and metalloprotease) family, including ADAM9, ADAM10, ADAM12, ADAM13, ADAM17, ADAM22, and ADAM23, were analyzed in the developing chicken lumbar spinal cord by in situ hybridization and immunohistochemistry. Results show that each individual ADAM is expressed and regulated spatiotemporally in the lumbar cord and its surrounding tissues. ADAM9, ADAM10, ADAM22, and ADAM23 are expressed predominantly by motoneurons in the motor column and by sensory neurons in the dorsal root ganglia, each with a different expression pattern. ADAM12 and ADAM13 are mainly expressed in the meninges around the lumbar cord and in the condensed sheets of chondroblasts around the vertebrae. ADAM17 expression is strong in the ventricular layer and limited to early stages. The differential expression of the ADAMs in the lumbar cord suggests that the ADAMs play a regulatory role in development of the spinal cord. Developmental Dynamics 239:1246-1254,

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ADAM23 Plays Multiple Roles in Neuronal Differentiation of P19 Embryonal Carcinoma cells

Cited by 13 publications

References 29 publications

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development

Dendritic cell expression of ADAM23 governs T cell proliferation and cytokine production through the α(v)β(3) integrin receptor

Expression of seven members of the ADAM family in developing chicken spinal cord

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