Adalékok az időskori maculadegeneráció –                     etiopatogeneziséből fakadó – gyógyszeres intervenciójához

Fischer, Tamás

doi:10.1556/650.2015.30207

Cited by 3 publications

(1 citation statement)

References 55 publications

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“…The mutations in complement factor H, which is a tyrosine-sulfated protein, have been confirmed to affect AMD development [ 27 , 28 ]. Arginine had beneficial effects on endothelial dysfunction for alleviating chronic inflammation of AMD [ 29 ]. In cases of bevacizumab- and ranibizumab-resistant wet AMD, hydrocortisone is needed to treat macular intraretinal fluid in the eyes [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Plasma metabolomic study in Chinese patients with wet age-related macular degeneration

et al. 2017

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BackgroundAge-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences.MethodsWe used ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry for this analysis. The relationship of these differences with AMD pathophysiology was also assessed. Remaining data were normalized using Pareto scaling, and then valid data were handled using multivariate data analysis with MetaboAnalysis software, including unsupervised principal component analysis and supervised partial least squares-discriminate analysis. The purpose of the present work was to identify significant metabolites for the analyses. Hierarchical clustering was conducted to identify metabolites that differed between the two groups. Significant metabolites were then identified using the established database, and features were mapped on the Kyoto Encyclopedia of Genes and Genomes.ResultsA total of 5443 ion peaks were detected, all of them attributable to the same 10 metabolites. These included some amino acids, isomaltose, hydrocortisone, and biliverdin. The heights of these peaks differed significantly between the two groups. The biosynthesis of amino acids pathways also differed profoundly between patients with wet AMD and controls.ConclusionsThese findings suggested that metabolic profiles and and pathways differed between wet AMD and controls and may provide promising new targets for AMD-directed therapeutics and diagnostics.

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Section: Discussionmentioning

confidence: 99%

Plasma metabolomic study in Chinese patients with wet age-related macular degeneration

et al. 2017

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Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration

Jabbehdari

Handa²

2021

Survey of Ophthalmology

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The novel ZIP4 regulation and its role in ovarian cancer

Fan

Cai

et al. 2017

Oncotarget

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Our RNAseq analyses revealed that ZIP4 is a top gene up-regulated in more aggressive ovarian cancer cells. ZIP4's role in cancer stem cells has not been reported in any type of cancer. In addition, the role and regulation of ZIP4, a zinc transporter, have been studied in the context of extracellular zinc transporting. Factors other than zinc with ZIP4 regulatory effects are essentially unknown. ZIP4 expression and its regulation in epithelial ovarian cancer cells was assessed by immunoblotting, quantitative PCR, or immunohistochemistry staining in human ovarian tissues. Cancer stem cell-related activities were examined to evaluate the role of ZIP4 in human high-grade serous ovarian cancer cells in vitro and in vivo. RNAi and CRISPR techniques were used to knockdown or knockout ZIP4 and related genes. Ovarian cancer tissues overexpressed ZIP4 when compared with normal and benign tissues. ZIP4 knockout significantly reduced several cancer stem cell-related activities in EOC cells, including proliferation, anoikis-resistance, colony-formation, spheroid-formation, drug-resistance, and side-population in vitro. ZIP4-expressing side-population highly expressed known CSC markers ALDH1 and OCT4. ZIP4 knockout dramatically reduced tumorigenesis and ZIP4 overexpression increased tumorigenesis in vivo. In addition, the ZIP4-expressing side-population had the tumor initiating activity. Moreover, the oncolipid lysophosphatic acid effectively up-regulated ZIP4 expression via the nuclear receptor peroxisome proliferator-activated receptor gamma and lysophosphatic acid 's promoting effects in cancer stem cell-related activities in HGSOC cells was at least partially mediated by ZIP4 in an extracellular zinc-independent manner. Our critical data imply that ZIP4 is a new and important cancer stem cell regulator in ovarian cancer. Our data also provide an innovative interpretation for the apparent disconnection between low levels of zinc and up-regulation of ZIP4 in ovarian cancer tissues.

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Adalékok az időskori maculadegeneráció – etiopatogeneziséből fakadó – gyógyszeres intervenciójához

Cited by 3 publications

References 55 publications

Plasma metabolomic study in Chinese patients with wet age-related macular degeneration

Plasma metabolomic study in Chinese patients with wet age-related macular degeneration

Oxidative stress as a therapeutic target for the prevention and treatment of early age-related macular degeneration

The novel ZIP4 regulation and its role in ovarian cancer

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