Acylresorcinols from seed kernels of Myristica dactyloides

Acylphenols fromMyristica crassaas New Acetylcholinesterase Inhibitors

“…In this genus, Myristica fragrans and other Myristica species are used in folk medicine in Asia [2]. They are known to produce lignans and acylphenols mainly of the 2,6-dihydroxyphenyl type such as malabaricones A -D [3], [4], [5], [6], [7]. These acylphenols showed interesting antimicrobial activity [5], cytotoxicity on various cell lines [6], [7], antinematocidal activity [8], antipromastigote activity [9] and a healing property against indomethacin-induced gastric ulceration [10].…”

“…In continuation of our search for novel bioactive compounds from the Malayan flora, we have launched a bioassay-guided study on an ethyl acetate extract of the fruits of M. crassa King, which exhibited potent acetylcholinesterase inhibitory activity. This study, which was accomplished with the aid of HPLC, HPLC-ESI-MS and NMR analysis, led to the isolation and identification of three new acylphenol dimers, giganteone C (5) and maingayones B and C (6 and 7) along with the known malabaricones B (2) and C (3) and giganteone A (4). Herein, we report the structural characterization of the new compounds and the acetylcholinesterase inhibitory activity of the compounds isolated along with malabaricone A (1) and promalabaricones B and C (8 and 9), previously isolated from M. maingayi [6] (• " Fig.…”

One Alkenylphenol and Steroids from the Aquatic Plant Monochoria Vaginalis

“…These NMR data suggested compound 1 possesses one carbonyl group, two hydroxyl groups as well as a disubstituted double bond in the C 18 side chain. 13,14 The presence of a base fragmentation peak in HR-EIMS spectrum at m/z 137.0243 (Calcd for C7H5O3; 137.0239) suggested the existence of a dihydroxybenzoyl moiety in 1. The side chain olefin adopting a Z configuration could be supported by CH 2 peaks at d 27.5, 27.7 (C-9¢, 12¢) in 13 C-NMR spectrum since the chemical shift values of allylic methylene were around d 27 and 33 for cis and trans olefine, respectively.…”

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“…A stable and spherical shaped silver nanoparticle was synthesized using extract of Abutilon indicum. These nanoparticles show high antimicrobial activities against S. typhi, E. coli, S. aureus and B. substilus microorganisms [30], [31].…”