Acylmethylidenepyrrolo[1,2-c]oxazoles via [3+2]-cyclization of 2-acylethynylpyrroles with carbonyl compounds

Abstract

Acylethynylpyrroles, readily available from acylbromoacetylenes and pyrroles, smoothly undergo [3+2]-cyclization with ketones and aldehydes (room temperature) to give acylmethylidenepyrrolo[1,2-c]oxazoles in 43-82% yields.