Acylhydrazone bond dynamic covalent polymer gel monolithic column online coupling to high-performance liquid chromatography for analysis of sulfonamides and fluorescent whitening agents in food

Self Cite

Covalently cross‐linked microporous polymers are a new class of highly cross‐linked porous network materials with large surface area and potential superiority in sample pretreatment. In this work, a covalently cross‐linked microporous polymer was well designed and synthesized by condensation of acylhydrazines in terephthalic dihydrazide with aldehyde groups in 1,3,5‐benzenetricarboxaldehyde. The adsorption mechanism was explored and discussed based on π‐π stacking interaction and steric effect. Then, a covalently cross‐linked microporous polymer was employed as the adsorbent of online micro‐solid‐phase extraction coupled with high‐performance liquid chromatography for the enrichment and analysis of trace pesticide residues in citrus fruits. The method was successfully applied to the online analysis of sugar orange and Huangdigan samples with the detection limits of 0.10–0.30 μg/kg. It was satisfactory that chlorpifos and triazophos in real sugar orange and Huangdigan samples could be actually found and quantified at concentrations of 0.20 and 0.51 mg/kg, respectively. The recoveries of sugar orange and Huangdigan samples were in the range of 70.0–103 and 74.0–119% with relative standard deviations of 0.4–9.7 and 0.5–9.2% (n = 3), respectively. The proposed method was accurate, reliable, and convenient for the online simultaneous analysis of trace pesticide residues in citrus fruits.

Section: Resultssupporting

confidence: 91%

Section: Resultsmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A covalently cross‐linked microporous polymer based micro‐solid phase extraction for online analysis of trace pesticide residues in citrus fruits

Wei

Zhang

2019

Self Cite

“…These include fluorescence spectrophotometry , flow‐injection chemiluminescence , HPLC , UHPLC–MS/MS , and tri‐step IR spectroscopy . Recently, covalent organic polymers (COPs) have been synthesized for the gel monolithic column online coupling to HPLC for the analysis of FWAs in food samples . Moreover, COPs have been utilized for high‐performance sorbents for SPE, mainly because of their adjustable pore structure, large surface area, and extraordinary thermal stability .…”

Section: Introductionmentioning

confidence: 99%

Molecularly imprinted covalent organic polymers for the selective extraction of benzoxazole fluorescent whitening agents from food samples

Ding

Wang

et al. 2018

Molecularly imprinted covalent organic polymers were constructed by an imine-linking reaction between 1,3,5-triformylphloroglucinol and 2,6-diaminopyridine and used for the selective solid-phase extraction of benzoxazole fluorescent whitening agents from food samples. Binding experiments showed that imprinting sites on molecularly imprinted polymers had higher selectivity for targets compared with those of the corresponding non-imprinted polymers. Parameters affecting the solid-phase extraction procedure were examined. Under optimal conditions, actual samples were treated and the eluent was analyzed with high-performance liquid chromatography with diode-array detection. The results showed that the established method has a wide linearity, satisfactory detection limits and quantification limits, and acceptable recoveries. Thus, this developed method possesses the practical potential for the selective determination of benzoxazole fluorescent whitening agents in complex food samples.

“…Moreover, polymeric monolithic columns with different polarities and functional groups can be fabricated by varying their chemical composition and configuration according to the analysis requirements. Because of these advantages, several polymer-based monolithic columns have been successfully used for the on-line pretreatment of compounds from environmental, food, and biological matrixes [21][22][23][24][25][26][27][28][29][30][31], e.g., ion-exchange sorbents [22], reversed-phase monoliths [24], restricted access monoliths [26], molecularly imprinted polymers [27], and hydrophilic sorbents [30]. The polyfunctional monolith monomers will dictate the extraction performance of the target analytes.…”

Section: Introductionmentioning

confidence: 99%

Poly[(2‐(acryloyloxy) ethyl]trimethylammonium chloride‐co‐ethylene dimethacrylate monolith on‐line solid‐phase extraction coupled with liquid chromatography and tandem mass spectrometry for the fast determination of salicylic acid in foodstuffs

Wang

et al. 2018

We report the fabrication of an anion-exchange monolithic column in a stainless-steel chromatographic column (10 mm × 2.1 mm i.d.) using [2-(acryloyloxy) ethyl]trimethylammonium chloride as the monomer and ethylene dimethacrylate as the crosslinker. The prepared monolith was developed as the adsorbent for the on-line solid-phase extraction of salicylic acid in various animal-origin foodstuffs combined with liquid chromatography and tandem mass spectrometry. The monolith was characterized by using Fourier transform infrared spectroscopy, scanning electron microscopy, nitrogen adsorption analysis, and elemental analysis. Potential factors affecting the on-line solid-phase extraction and liquid chromatography with tandem mass spectrometry analysis were studied in detail. Under the optimized conditions, the total analysis time including cleanup and liquid chromatography with tandem mass spectrometry separation was 17 min. The developed method gave the linear range of 15-750 μg/kg, detection limits (S/N = 3) of 5 μg/kg, and quantification limits (S/N = 10) of 15 μg/kg. The recoveries obtained by spiking 10, 20, and 100 μg/kg of salicylic acid in the animal-origin food samples were in the range of 85.2-98.4%. In addition, the monolith was stable enough for 550 extraction cycles with the precision of peak area ≤11.6%.