Acylbenzotriazoles: New Allies for Short Linear and Cyclic Peptide Constructs

Nickel-Catalyzed Reductive Cross-Coupling of N-Acyl and N-Sulfonyl Benzotriazoles with Diverse Nitro Compounds: Rapid Access to Amides and Sulfonamides

“…Inspired by the above-mentioned achievements on reductive amidation using nitroarenes as the incoming amine source and the rich chemistry of N -acyl benzotriazole derivatives, we decided to explore the reductive transamidation of N -acyl benzotriazoles with nitro compounds. We envision that the N -acyl benzotriazoles would be valuable precursors for many transition-metal-catalyzed cross-coupling reactions not only because they are cheap, stable, and easy to prepare but also, more importantly, because the benzotriazole motif may endow the amide bond with a special reactivity due to the lower degree of coplanarity.…”