Acylated pregnane glycosides from Caralluma sinaica

Al-Massarani, Shaza M.; Bertrand, Samuel; Nievergelt, Andreas; El-Shafae, Azza M.; Al‐Howiriny, Tawfeq A.; Al-Musayeib, Nawal M.; Cuendet, Muriel; Wolfender, Jean‐Luc

doi:10.1016/j.phytochem.2012.04.003

Cited by 31 publications

(22 citation statements)

References 51 publications

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“…The cymarose and oleandrose moieties had thus D-configuration. Configuration of the β-thevetopyranosyl unit was presumed to be D-form because its NMR data were close to those in the literature [40,41,42] and l -thevetopyranose [43] is rarely found in Nature.…”

Section: Resultsmentioning

confidence: 68%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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Abstract:Four new pregnane glycosides 1-4 were isolated from the ethanol extract of the stem of Gymnema sylvestre and named gymsylvestrosides A-D. Hydrolysis of compound 1 under the catalysis of Aspergilus niger β-glucosidase afforded compound 5 (gymsylvestroside E). Their structures were determined by spectroscopic methods such as HRESIMS, 1D and 2D NMR, as well as HMQC-TOCSY experiment. Compounds 1-4 were screened for Saccharomyces cerevisiae α-glucosidase inhibitory activity.

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Section: Resultsmentioning

confidence: 68%

New Pregnane Glycosides from Gymnema sylvestre

Yang

Zhang

et al. 2015

Molecules

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“…The generic UHPLC 30 min gradient chosen (5-95% acetonitrile (ACN) + 0.1% formic acid (FA) on a 150 mm UHPLC column) is considered an optimal compromise between a reasonable analysis time and a high peak capacity for high resolution metabolite profiling and has already been successfully used elsewhere (Al-Massarani et al, 2012;Bertrand et al, 2013;Bohni et al, 2013). Such types of LC-MS conditions are commonly used in NP research and in metabolomic studies.…”

Section: Np Database Of Rt and Physicochemical Parametersmentioning

confidence: 99%

Retention time prediction for dereplication of natural products (CxHyOz) in LC–MS metabolite profiling

et al. 2014

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“…In these molecules, the sugar moiety is mostly linked at the C-3 position of the aglycone and generally occurs as a linear rather than a branched oligosaccharide chain (Panda et al, 2006). In recent years, several studies have reported that pregnane glycosides have considerable bioactivity, including compounds with antiproliferative (Cioffi et al, 2006;Plaza et al, 2005), cytotoxic (Braca et al, 2002;De Leo et al, 2005;Chen et al, 2010;Waheeda et al, 2011;Al-Massarani et al, 2012), antifungal (Yoon et al, 2011) and antidepressant (Yang et al, 2011) activities.…”

Section: Introductionmentioning

confidence: 99%