Acyl glucuronidation and glucosidation of pranoprofen, a 2-arylpropionic acid derivative, in mouse liver and kidney homogenates.

Metabolism and Lack of DNA Reactivity of the Mycotoxin Ochratoxin A in Cultured Rat and Human Primary Hepatocytes

“…In general, the conjugation with glucose or other aldoses is common in insects and bacteria but rare in mammals (). Examples are the conjugation of the drug pranoprofene with glucose in mice in vivo and in vitro ( , ) and the conjugation of endogenous substrates such as bilirubin or bile acids with glucose and xylose by different mammalian species, including humans, in vivo ( , ). It is presently unclear why OTA is not conjugated with glucuronic acid in rat hepatocytes.…”

Kinetic modelling of acyl glucuronide and glucoside reactivity and development of structure–property relationships

“…mycophenolic acid in humans 23 and the hydroxylated metabolites of diclofenac in the mouse. 24 The formation of acyl glucosides in vitro using microsomal preparations has been reported for several xenobiotics, including (R)-and (S)-ibuprofen, 25 pranoprofen 26 and the experimental endothelin antagonist Compound A. 27 Acyl glucoside metabolites of pranoprofen have also been observed in the mouse.…”

Glycosidation of an Endothelin ETA Receptor Antagonist and Diclofenac in Human Liver Microsomes: Aglycone-dependent UDP-sugar Selectivity

“…Interestingly, the preference for UDP-sugar donors of wild-type UGTs has been found not absolute. There are a considerable number of cases where the glycosyl group in the conjugate could also be derived from other UDP-sugars, especially UDP-Glc (Tang et al, 1979(Tang et al, , 2003Arima, 1990;Senafi et al, 1994;Chmela et al, 2001;Shipkova et al, 2001;Mackenzie et al, 2003). Even more intriguing is the reversed sugar donor specificity found by Toide et al (2004) showing that human UGT2B isoforms utilize only UDP-Glc, rather than UDP-GlcA, as a cofactor to conjugate an aldose reductase inhibitor.…”