Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression

Orlando, Ulises Daniel; Castillo, Ana Fernanda; Medrano, Mayra Agustina Ríos; Solano, Angela; Maloberti, Paula; Podestá, Ernesto J.

doi:10.1016/j.bcp.2018.11.005

Cited by 61 publications

(60 citation statements)

References 63 publications

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“…ACSL4 has been shown to participate in the chemoresistance of breast cancer cells by regulating ABC transporter expression. 85 Pancreatic cancer is one of the most aggressive gastrointestinal malignancies. Due to its potent chemotherapy resistance and poor prognosis, current chemotherapy drugs showed low therapeutic efficacy.…”

Section: The Interaction Modulates Tumor Invasion and Metastasismentioning

confidence: 99%

The interaction between ferroptosis and lipid metabolism in cancer

2020

Sig Transduct Target Ther

337

257

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Ferroptosis is a new form of programmed cell death characterized by the accumulation of iron-dependent lethal lipid peroxides. Recent discoveries have focused on alterations that occur in lipid metabolism during ferroptosis and have provided intriguing insights into the interplay between ferroptosis and lipid metabolism in cancer. Their interaction regulates the initiation, development, metastasis, therapy resistance of cancer, as well as the tumor immunity, which offers several potential strategies for cancer treatment. This review is a brief overview of the features characterizing the interaction between ferroptosis and lipid metabolism, and highlights the significance of this interaction in cancer.

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Section: The Interaction Modulates Tumor Invasion and Metastasismentioning

confidence: 99%

The interaction between ferroptosis and lipid metabolism in cancer

2020

Sig Transduct Target Ther

337

257

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“…Up-regulated ACSL4 expression has been previously characterised in extrahepatic cancers such as colon adenocarcinoma [71], lung [5,39], breast [34,35,41,72,73] and prostate cancers [72]. Increased ACSL4 expression is a determinant of drug resistance in metastatic breast cancer cells where altered cellular energetics leads to increased expression of the ATP-binding cassette (ABC) transporter, which mediates the egress of chemotherapeutic molecules [35]. A similar scenario exists for prostate cancer where increased ACSL4 is associated with increased aggressiveness, therapeutic resistance and enhanced anti-apoptotic signalling [43,72].…”

Section: Discussionmentioning

confidence: 99%

“…ACSL4 is also associated with the ER and lipid droplets [30,31] but endosomal [32], plasma membrane [30], peroxisomal [33] and secretory vesicle [29] localisations have also been reported. Importantly, there is emerging evidence that dysregulated expression of both ACSL3 and ACSL4 is associated with disease and especially with cancer [15,28,[34][35][36][37][38]. ACSL3 can promote cancer cell survival through amplified fatty acid β-oxidation [5,37] and increased arachidonic acid-dependent prostaglandin synthesis [39], both of which can drive tumour growth.…”

Section: Introductionmentioning

confidence: 99%

“…ACSL3 can promote cancer cell survival through amplified fatty acid β-oxidation [5,37] and increased arachidonic acid-dependent prostaglandin synthesis [39], both of which can drive tumour growth. ACSL4 has also been ascribed functions relevant to oncogenesis; these include ferroptosis, an iron-dependent, non-apoptotic, cell-death pathway [40], metabolic rewiring resulting in drug resistance [35], arachidonic acid-dependent tumorigenesis [41], steroidogenesis [42] and the activation of intracellular, pro-oncogenic signalling pathways [43].…”

Section: Introductionmentioning

confidence: 99%

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Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases

et al. 2020

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Long-chain fatty acyl CoA synthetases (ACSLs) activate fatty acids by CoA addition thus facilitating their intracellular metabolism. Dysregulated ACSL expression features in several cancers and can affect processes such as ferroptosis, fatty acid β-oxidation, prostaglandin biosynthesis, steroidogenesis and phospholipid acyl chain remodelling. Here we investigate long chain acyl-CoA synthetase 3 (ACSL3) and long chain acyl-CoA synthetase 4 (ACSL4) expression in liver malignancies. The expression and subcellular localisations of the ACSL3 and ACSL4 isoforms in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA) and hepatic metastases were assessed by immunohistochemical analyses of multiple tumour tissue arrays and by subcellular fractionation of cultured HepG2 cells. The expression of both enzymes was increased in HCC compared with normal liver. Expression of ACSL3 was similar in HCC and hepatic metastases but lower in healthy tissue. Increased ACSL3 expression distinguished HCC from CCA with a sensitivity of 87.2% and a specificity of 75%. ACSL4 expression was significantly greater in HCC than in all other tumours and distinguished HCC from normal liver tissue with a sensitivity of 93.8% and specificity of 93.6%. Combined ACSL3 and ACSL4 staining scores distinguished HCC from hepatic metastases with 80.1% sensitivity and 77.1% specificity. These enzymes had partially overlapping intracellular distributions, ACSL4 localised to the plasma membrane and both isoforms associated with lipid droplets and the endoplasmic reticulum (ER). In conclusion, analysis of ACSL3 and ACSL4 expression can distinguish different classes of hepatic tumours.

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“…Di mana η adalah konstant, E adalah energi (195)(196)(197)(198) untuk aktivasi (199)(200)(201) Flow16 kental, η dan R adalah konstanta gas (70; 202; 203) . Dalam sistem metrik satuan viskositas disebut stoke dan mempunyai satuan centimeter kuadrat perdetik.…”

Section: Viskositas Mgclunclassified

Magnesium Klorida (MgCl2): Karakteristik dan Dinamika Molekuler Pada MgCl2

Wildayati¹,

Zainul²

2019

Preprint

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Magnesium klorida adalah salah satu senyawa kimia dengan rumus MgCl2 dan bentuk hidrat MgCl2.H2O. Magnesium klorida merupakan logam yang kuat, memiliki titik didih 714°C dan titik lebur 1412 °C mampu larut dalam air, serta memiliki sifat thermodinamika seperti∆Hf 298 sebesar-641,3kj/mol dan∆Gf 298 sebesar -591,8 kj/mol. Senyawa ini dapat diperoleh dengan proses kristalisasi dan elektrolisis atau dari reaksi Mg(OH)2 dengan HCl. Magnesium klorida merupakan salah satu garam yang memiliki peranan penting pada industri kimia dan banyak kegunaan dalam kehidupan sehari-hari seperti de-icer, liquid tirest ballast, foam pada instalasi kebakaran. Penelitian ini bertujuan untuk mengetahui karakteristik molekul, dan menganalisis dinamika molekuler serta transport ion pada MgCl2 . Metode yang digunakan adalah metode optimasi dilakukan dengan menggunakan aplikasi Chemoffice3D 15.0 dan ChemDraw Profesional 15.0. Dilihat dari penggambaran chemoffice 15.0 senyawa MgCl2 memiliki karakterisasi transfor ionik yang dapat diukur dari parameter mobilitas ion. Konduktivitas viskositas, dan gerakan hanyut.?Dari?parameter?yang diukur diperoleh?nilai perhitungan kecepatan hanyut Magnesium Klorida (MgCl2) dengan potensial 3,61 V dan jarak antara elektroda adalah 1,5 cm adalah 2, 407 V/ cm.

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Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression

Cited by 61 publications

References 63 publications

The interaction between ferroptosis and lipid metabolism in cancer

The interaction between ferroptosis and lipid metabolism in cancer

Immunohistochemical staining reveals differential expression of ACSL3 and ACSL4 in hepatocellular carcinoma and hepatic gastrointestinal metastases

Magnesium Klorida (MgCl2): Karakteristik dan Dinamika Molekuler Pada MgCl2

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