Acyl azides

Partially Modified Retro-Inverso Peptides: Development, Synthesis, and Conformational Behavior

“…The literature contains other classical and more modern routes to acyl azides; − these have been but little used in PMRI peptide synthesis. The only example of the use of TMS azide to synthesize an acyl azide en route to a PMRI peptide is Fincham et al's synthesis of CCK-B ligands .…”

Highly Efficient Synthesis and Inclusion Properties of Star-Shaped Amphiphilic Derivatives of Cholic Acid

“…27 Cholano acyl azide 10 was found to be stable in the presence of hydroxyl groups on cholic acid, and treated directly with triaminoethyl amine in the presence of triethyl amine, giving a tripodal cholamide 16 in 68% yield, which has been reported as a hydrogelator prepared via a condensation strategy with steps of protection and deprotection of hydroxyl groups on cholic acid. 12 Trimer 14 and tetramers 7 and 15 can serve as host molecules in aqueous media to enhance the solubility of Scheme 1 Synthesis of trimer and tetramer derivatives of cholic acid using click chemistry pyrene, a fluorescent probe used in the study of the molecular interactions.…”

Too Short-Lived or Not Existing Species: N-Azidoamines Reinvestigated

“…The azido unit belongs to the most important functional groups in chemistry because of a variety of applications, particularly in the case of organic azides . Not only carbon but also most elements in the periodic table form a bond to azide; however, only a few of the corresponding covalent compounds are of general interest, for example, as reagents in synthetic chemistry, such as hydrazoic acid, silyl azides, phosphoryl azides, and sulfonyl azides. , In particular, azides attached to another nitrogen atom have only rarely been reported. − Such azides, in which the azide-bearing additional nitrogen atom is always connected with at least one strongly electron-withdrawing group, turned out to be very unstable. On the other hand, N -azidoamines, particularly those derived from nitrogen heterocycles, − attracted attention in numerous quantum chemical studies because these compounds are discussed as high energy density compounds (HEDCs).…”