Acyclovir Delivery Matrices Based on Poly(Ethylene Glycol)/Chitosan Semi-Interpenetrating Networks

Dı́ez-Sales, Octavio; Dolz, M.; Hernández, M. J.; Casanovas, A.; Herráez, M.

doi:10.1002/jps.20825

Cited by 9 publications

(2 citation statements)

References 15 publications

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“…16 Actually, several combinations of chitosan with inorganic polymers have been investigated and used for drug delivery, and protein adsorbtion applications. [17][18][19][20] However, among the polymers, poly(vinylpyrrolidone) (PVP) is recognized to be a good candidate due to its good biocompatibility. Although chitosan-PVP blends do not exist in nature, certainly the combined use of both of them has resulted in hydrogels with unique structural and mechanical properties, as shown by their use in prosthetic implants.…”

Section: Introductionmentioning

confidence: 99%

Physico-chemical and structural properties of hydrogels formed by chitosan, in the presence and absence of poly(vinylpyrrolidone) and sodium decylsulfate

Mangiapia

Frielinghaus

D’Errico

et al. 2007

Phys. Chem. Chem. Phys.

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The structure of chemically-crosslinked chitosan and chitosan-poly(vinylpyrrolidone) (PVP) hydrogels is investigated by means of the combined use of small-angle neutron scattering (SANS), electron paramagnetic resonance spectroscopy (EPR), intradiffusion, and swelling degree measurements. These hydrogels may be described in terms of an inhomogeneous structure composed by polymer-rich and polymer-poor regions. The polymer-rich regions, whose correlation distance zeta is ranged between approximately 600 and approximately 850 A, are, in turn, characterized by the presence of a network formed by the chemical crosslinks, with a mean correlation distance xi approximately 90 A. The structures of chitosan and chitosan-PVP hydrogels have also been analyzed in the presence of sodium decylsulfate micelles that could provide a multidomain system useful, in principle, for drug delivery applications. Both SANS and EPR measurements show that sodium decylsulfate micelles do not significantly interact with both the gels. Finally, intradiffusion and swelling degree measurements show an improved hydrophilicity of chitosan-PVP gels, even further magnified by the presence of C10OS surfactant.

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Section: Introductionmentioning

confidence: 99%

Physico-chemical and structural properties of hydrogels formed by chitosan, in the presence and absence of poly(vinylpyrrolidone) and sodium decylsulfate

Mangiapia

Frielinghaus

D’Errico

et al. 2007

Phys. Chem. Chem. Phys.

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“…Chitosan, one of the polysaccharides, is known to be biocompatible, biodegradable, and mucoadhesive [ 20 – 22 ]. Because of its many advantages, chitosan has been extensively investigated for pharmaceutical, cosmetics, biomedical, and biotechnological applications [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer

Cho

et al. 2018

Biomater Res

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BackgroundMucoadhesive polymers, which may increase the contact time between the polymer and the tissue, have been widely investigated for pharmaceutical formulations. In this study, we developed a new polysaccharide-based mucoadhesive polymer with thermogelling properties.MethodsHexanoyl glycol chitosan (HGC), a new thermogelling polymer, was synthesized by the chemical modification of glycol chitosan using hexanoic anhydride. The HGC was further modified to include thiol groups to improve the mucoadhesive property of thermogelling HGC. The degree of thiolation of the thiolated HGCs (SH-HGCs) was controlled in the range of 5–10% by adjusting the feed molar ratio. The structure of the chemically modified polymers was characterized by 1H NMR and ATR-FTIR. The sol-gel transition, mucoadhesiveness, and biocompatibility of the polymers were determined by a tube inverting method, rheological measurements, and in vitro cytotoxicity tests, respectively.ResultsThe aqueous solution (4 wt%) of HGC with approximately 33% substitution showed a sol-gel transition temperature of approximately 41 °C. SH-HGCs demonstrated lower sol-gel transition temperatures (34 ± 1 and 31 ± 1 °С) compared to that of HGC due to the introduction of thiol groups. Rheological studies of aqueous mixture solutions of SH-HGCs and mucin showed that SH-HGCs had stronger mucoadhesiveness than HGC due to the interaction between the thiol groups of SH-HGCs and mucin. Additionally, we confirmed that the thermogelling properties might improve the mucoadhesive force of polymers. Several in vitro cytotoxicity tests showed that SH-HGCs showed little toxicity at concentrations of 0.1–1.0 wt%, indicating good biocompatibility of the polymers.ConclusionsThe resultant thiolated hexanoyl glycol chitosans may play a crucial role in mucoadhesive applications in biomedical areas.

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Self-assembled particles of N-phthaloylchitosan-g-polycaprolactone molecular bottle brushes as carriers for controlled release of indometacin

Huang

Fang

2009

J Mater Sci: Mater Med

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A series of amphiphilic N-phthaloylchitosan-g-polycaprolactone molecular bottle brushes were prepared by "graft onto" method. The narrow distribution of polycaprolactone macromonomers ensures that the molecular bottle brushes can self-assemble into highly monodisperse particles, which have the ability to get a high loading efficiency of the hydrophobic drug, indometacin (INN). Searching for the effective drug loading ratio, three parameters such as polycaprolactone chain length, the grafting content and concentration of the molecular bottle brushes were tested to entrap INN. These encapsulated drug particles show sustained release of the encapsulated INN, of which 91.7% was released in 22 h at 37 degrees C in phosphate buffered saline. The self-assembled particles of the molecular bottle brushes as carriers for INN can effectively prevent the drug from releasing quickly and prolong the release time, which is a promising candidate for potential clinical applications.

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Acyclovir Delivery Matrices Based on Poly(Ethylene Glycol)/Chitosan Semi-Interpenetrating Networks

Cited by 9 publications

References 15 publications

Physico-chemical and structural properties of hydrogels formed by chitosan, in the presence and absence of poly(vinylpyrrolidone) and sodium decylsulfate

Physico-chemical and structural properties of hydrogels formed by chitosan, in the presence and absence of poly(vinylpyrrolidone) and sodium decylsulfate

Synthesis and characterization of thiolated hexanoyl glycol chitosan as a mucoadhesive thermogelling polymer

Self-assembled particles of N-phthaloylchitosan-g-polycaprolactone molecular bottle brushes as carriers for controlled release of indometacin

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