Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice

Hu, Zhuozhou; Zhou, Jing; Han, Liang; Li, Xiangxiang; Li, Chun; Wu, Tongyu; Liu, Jingjing; Zhao, Wenyang; Kang, Jia; Chen, Xinping

doi:10.1016/j.lfs.2022.120725

Cited by 3 publications

(2 citation statements)

References 54 publications

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“…4a ). Using the databases, the corresponding drugs are Cynaropicrin, an inhibitor of RELA 52 , Acyclovir, which is an antiviral agent previously shown to reduce insulin resistance in a mouse model 53 , and Liquiritin, which has shown anti-inflammatory effects 54 . To test the impact on caspase 3/7, we treated our SC-islets with BFA for 24 h and then added each drug at different concentrations for an additional 24 h (Fig.…”

Section: Resultsmentioning

confidence: 99%

Identification of unique cell type responses in pancreatic islets to stress

Maestas,

Ishahak,

Augsornworawat

et al. 2024

Nat Commun

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Diabetes involves the death or dysfunction of pancreatic β-cells. Analysis of bulk sequencing from human samples and studies using in vitro and in vivo models suggest that endoplasmic reticulum and inflammatory signaling play an important role in diabetes progression. To better characterize cell type-specific stress response, we perform multiplexed single-cell RNA sequencing to define the transcriptional signature of primary human islet cells exposed to endoplasmic reticulum and inflammatory stress. Through comprehensive pair-wise analysis of stress responses across pancreatic endocrine and exocrine cell types, we define changes in gene expression for each cell type under different diabetes-associated stressors. We find that β-, α-, and ductal cells have the greatest transcriptional response. We utilize stem cell-derived islets to study islet health through the candidate gene CIB1, which was upregulated under stress in primary human islets. Our findings provide insights into cell type-specific responses to diabetes-associated stress and establish a resource to identify targets for diabetes therapeutics.

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Section: Resultsmentioning

confidence: 99%

Identification of unique cell type responses in pancreatic islets to stress

Maestas,

Ishahak,

Augsornworawat

et al. 2024

Nat Commun

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“…TNF-α has been shown to promote insulin resistance in different ways, such as TNF-α may increase insulin resistance by inhibiting the entry of glucose into smooth muscle cells ( Savage et al., 2007 ; Rowan et al., 2018 ; Wang et al., 2022a ). There is evidence that anti-tnf antibody treatment improves hepatic IR ( Hu et al., 2022 ; Sinha and Haque, 2022 ). Resistin, an adipocyte-derived signaling polypeptide thought to have increased expression in inflammatory diseases and diabetes, named for its function in resisting insulin,is also a pro-inflammatory molecule ( Hiroshima et al., 2012 ; Hrishi et al., 2016 ; Govindaraj et al., 2021 ).…”

Section: Pathogenesis Of Insulin Resistance Caused By P Gin...mentioning

confidence: 99%

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

Jia

2023

Front. Cell. Infect. Microbiol.

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Porphyromonas gingivalis (P. gingivalis) is a Gram-negative oral anaerobic bacterium that plays a key role in the pathogenesis of periodontitis. P. gingivalis expresses a variety of virulence factors that disrupt innate and adaptive immunity, allowing P. gingivalis to survive and multiply in the host and destroy periodontal tissue. In addition to periodontal disease, P.gingivalis is also associated with systemic diseases, of which insulin resistance is an important pathological basis. P. gingivalis causes a systemic inflammatory response, disrupts insulin signaling pathways, induces pancreatic β-cell hypofunction and reduced numbers, and causes decreased insulin sensitivity leading to insulin resistance (IR). In this paper, we systematically review the studies on the mechanism of insulin resistance induced by P. gingivalis, discuss the association between P. gingivalis and systemic diseases based on insulin resistance, and finally propose relevant therapeutic approaches. Overall, through a systematic review of the mechanisms related to systemic diseases caused by P. gingivalis through insulin resistance, we hope to provide new insights for future basic research and clinical interventions for related systemic diseases.

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Study on the therapeutic effect and mechanism of Tangningtongluo Tablet on diabetic mice

Cai

Gui

et al. 2023

Journal of Diabetes and its Complications

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Acyclovir alleviates insulin resistance via activating PKM1 in diabetic mice

Cited by 3 publications

References 54 publications

Identification of unique cell type responses in pancreatic islets to stress

Identification of unique cell type responses in pancreatic islets to stress

Host insulin resistance caused by Porphyromonas gingivalis-review of recent progresses

Study on the therapeutic effect and mechanism of Tangningtongluo Tablet on diabetic mice

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