Acyclic Pyrimidine Nucleoside Analogues: Influence on Growth of L5178y Mouse Lymphoma Cells and Antiherpes Activity in KB Cells

Allen, Lois B.; Schröder, Heinz C.; Ζahn, Rudolf K.; Stoss, Peter; Maidhof, Armin; Müller, Wernér E.G.

doi:10.1159/000238328

Cited by 2 publications

(3 citation statements)

References 17 publications

(37 reference statements)

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“…The generation time of the logarithmically growing cells was 10.5 h. Dose-re sponse experiments (inoculation, 5 x l0 3 cells/ml) were performed as described previously [1], The cells were incubated at 37°C in roller tubes for 72 h; the controls reached a cell concentration of about 3 x I05 cells/ml. The cells needed 120 h to reach the station ary phase.…”

Section: Cell Culturementioning

confidence: 99%

“…The cytopathic effect (CPE) and drug cytotoxi city were observed microscopically and scored on a 0-4 basis with 4 representing total cell destruction [1], The minimum inhibitory concentration (MIC, con- 1 Mean of 6 assays (HSV-1 data) or 3 assays (HSV-2 data).…”

Section: Antiviral Evaluationsmentioning

confidence: 99%

“…This drug has been shown to exert an antiviral activity especially against 1 This work was supported by a grant from Fonds der Chemischen Industrie (W.E.G.M. ; No.…”

Section: Introductionmentioning

confidence: 99%

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Cytostatic and Antiherpesvirus Type 1 and 2 Activities of 1-β-D-Arabinofuranosylthymine (Ara T) Prodrugs

et al. 1987

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A series of derivatives of the antibiotic 1-β-D-arabinofuranosylfhymine (ara T) was synthesized by esterification of the hydroxy group in the 5′-position of the arabinose moiety of the nucleoside with straight-chain and branched-chain carboxylic acids: acetyl-ara T, butyryl-ara T, valeroyl-ara T, pivaloyl-ara T and palmitoyl-ara T. These ara T prodrugs were evaluated for their effect on growth of L5178y mouse lymphoma cells and noninfected BHK-21 cells as well as for their antiviral activity in Herpes simplex virus type 1 and 2 infected BHK-21 cells. All compounds exhibited a marked antiherpes virus activity, whereas the cytostatic activity of two of them, the pivaleric ester and the palmitic ester, was extremely weak. The relative antiviral indices of the 5′-pivaloyl-ara T and 5′-palmitoyl-ara T were found to be much better than the index of ara T itself.

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Section: Cell Culturementioning

confidence: 99%

Section: Antiviral Evaluationsmentioning

confidence: 99%

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Cytostatic and Antiherpesvirus Type 1 and 2 Activities of 1-β-D-Arabinofuranosylthymine (Ara T) Prodrugs

et al. 1987

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Acyclonucleosides: Part 2. diseco-Nucleosides**Part 1 is in Volume 67 and Part 3 is in Volume 69.

Ashry

Kilany

1997

Advances in Heterocyclic Chemistry

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This chapter is the second of a sequence of three chapters that appears in successive volumes of this series dealing with the chemistry of acyclonucleosides. The first chapter appeared in the previous volume [97AHC391] and dealt with seco-nucleosides (one bond disconnection). This chapter deals with diseco-nucleosides (two bond disconnections). The final chapter of this series will deal with tri-, tetra-, and pentuseco-nucleosides, as well as contain an appendix of the literature that appeared after the three chapters were prepared. diseco-Nucleosides from Two Bond DisconnectionsAcyclonucleosides that are considered under this type of disconnection are those resulting from omitting any two bonds from the pentose. There are seven such types.

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Acyclic Pyrimidine Nucleoside Analogues: Influence on Growth of L5178y Mouse Lymphoma Cells and Antiherpes Activity in KB Cells

Cited by 2 publications

References 17 publications

Cytostatic and Antiherpesvirus Type 1 and 2 Activities of 1-<i>β</i>-<i>D</i>-Arabinofuranosylthymine (Ara T) Prodrugs

Cytostatic and Antiherpesvirus Type 1 and 2 Activities of 1-<i>β</i>-<i>D</i>-Arabinofuranosylthymine (Ara T) Prodrugs

Acyclonucleosides: Part 2. diseco-Nucleosides**Part 1 is in Volume 67 and Part 3 is in Volume 69.

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