1997
DOI: 10.1159/000150563
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Acyclic Nucleoside Phosphonates in the Chemotherapy of DNA Virus and Retrovirus Infections

Abstract: The acyclic nucleoside phosphonates [HPMPC (cidofovir), PMEA (adefovir) and PMPA] have proved to be effective in vitro (cell culture systems) and in vivo (animal models, clinical studies) against a wide variety of DNA virus and retrovirus infections: i.e., HPMPC against herpesvirus (herpes simplex virus type 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus, human herpesvirus types 6, 7, and 18), polyoma-, papilloma-, adeno-, and poxvirus (vaccinia virus, molluscum contagiosum virus) infecti… Show more

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Cited by 72 publications
(28 citation statements)
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“…These drugs have been shown to be effective against a wide range of DNA viruses and retroviruses (reviewed in reference 8), and one of these compounds, (S)-1-[3-hydroxy-2-(phosphonylmethoxypropyl)]cytosine, also known as cidofovir (CDV), has been granted Food and Drug Administration approval for the treatment of cytomegalovirus (CMV)-induced retinitis. CDV has been used off label in the treatment of orf (11) and molluscum contagiosum (21) virus infections.…”
mentioning
confidence: 99%
“…These drugs have been shown to be effective against a wide range of DNA viruses and retroviruses (reviewed in reference 8), and one of these compounds, (S)-1-[3-hydroxy-2-(phosphonylmethoxypropyl)]cytosine, also known as cidofovir (CDV), has been granted Food and Drug Administration approval for the treatment of cytomegalovirus (CMV)-induced retinitis. CDV has been used off label in the treatment of orf (11) and molluscum contagiosum (21) virus infections.…”
mentioning
confidence: 99%
“…Cidofovir (1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl] cytosine; CDV) is an acyclic phosphonate analog of cytosine that has been shown to have activity against all doublestranded DNA viruses studied to date, including herpes group viruses, orthopoxviruses, parapoxviruses, adenoviruses, and papovaviruses (De Clercq et al, 1987;Snoeck et al, 1988;De Clercq, 1997). CDV (Vistide; Gilead Sciences, Foster City, CA) is approved as an intravenous treatment for cytomegalovirus retinitis in AIDS patients but has doselimiting renal side effects (Lea and Bryson, 1996;Plosker and Noble, 1999).…”
mentioning
confidence: 99%
“…Potential nephrotoxicity (27) and poor oral bioavailability (14), however, may limit its widespread use in the event of a smallpox outbreak. The inhibitory effect of another ANP, PMEA, against retro-, herpes-and hepadnaviruses has been demonstrated (18,36). The low oral bioavailability in animals and humans (14) of this compound, which is a common feature of ANPs, led to the development of an oral prodrug, adefovir dipivoxil [bis(pivaloyl)oxymethyl PMEA], which was recently approved for treatment of hepatitis B (M. B. McClellan, Letter, JAMA 288:2112, 2002).…”
mentioning
confidence: 99%