Acutely Exacerbated Hypertension and Increased Inflammatory Signs Due to Radiation Treatment for Metastatic Pheochromocytoma.

Teno, Shinichi; Tanabe, Akiyo; Nomura, Kazuhiro; Demura, Hiroshi

doi:10.1507/endocrj.43.511

Cited by 23 publications

(13 citation statements)

References 19 publications

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“…Hypertension (either sustained or episodic in nature), headache, palpitations, sweating, and weight loss are common presenting symptoms. 13,17 Spinal metastatic paragangliomas have led to pathologic fractures and spinal cord compression. 15 The clinical appearance of these tumours when they do not secrete catecholamines is nonspecific.…”

Section: Discussionmentioning

confidence: 99%

Paraganglioma of the thoracic spine

Zılelı

Kalaycı

Başdemir

2008

Journal of Clinical Neuroscience

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Section: Discussionmentioning

confidence: 99%

Paraganglioma of the thoracic spine

Zılelı

Kalaycı

Başdemir

2008

Journal of Clinical Neuroscience

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“…However, during radiation therapy the patient should be closely monitored to avoid acutely exacerbated hypertension and inflammatory signs caused by radiationinduced tumour destruction (Teno et al 1996).…”

Section: External Radiotherapymentioning

confidence: 99%

The diagnosis and management of malignant phaeochromocytoma and paraganglioma

Chrisoulidou

Kaltsas²,

Ilias³

et al. 2007

Endocr Relat Cancer

293

219

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Malignant phaeochromocytomas are rare tumours accounting for w10% of all phaeochromocytomas; the prevalence of malignancy among paragangliomas is higher, especially those associated with succinate dehydrogenase subunit B gene mutations. Although a subset of these tumours has metastatic disease at initial presentation, a significant number develops metastases during follow-up after excision of an apparently benign tumour. Clinical, biochemical and histological features cannot reliably distinguish malignant from benign tumours. Although a number of recently introduced molecular markers have been explored, their clinical significance remains to be elucidated from further studies. Several imaging modalities have been utilised for the diagnosis and staging of these tumours. Functional imaging using radiolabelled metaiodobenzylguanidine (MIBG) and more recently, 18 F-fluorodopamine and 18 F-fluorodopa positron emission tomography offer substantial sensitivity and specificity to correctly detect metastatic phaeochromocytoma and paraganglioma and helps identify patients suitable for treatment with radiopharmaceuticals. The 5-year mortality rate of patients with malignant phaeochromocytomas and paragangliomas greater than 50% indicates that there is considerable room for the improvement of currently available therapies. The main therapeutic target is tumour reduction and control of symptoms of excessive catecholamine secretion. Currently, the best adjunctive therapy to surgery is treatment with radiopharmaceuticals using 131 I-MIBG; however, this is very rarely curative. Chemotherapy has been used for metastatic disease with only a partial and mainly palliative effect. The role of other forms of radionuclide treatment either alone or in combination with chemotherapy is currently evolving. Ongoing microarray studies may provide novel intracellular pathways of importance for proliferation/cell cycle control, and lead to the development of novel pharmacological agents.

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“…Without treatment, the 5-year survival is generally less than 50% [15]. Alternatives to surgical resection include external beam radiation [28], cryoablation, radiofrequency ablation, transcatheter arterial embolization [29], and radiopharmaceutical therapy. All of these treatments were difficult for our patient.…”

Section: Discussionmentioning

confidence: 99%

A Case of Malignant Pheochromocytoma with Holt-Oram Syndrome

et al. 2008

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Abstract.A 23-year-old female patient with malignant pheochromocytoma was admitted to the Tokyo Women's Medical University. The patient had been clinically diagnosed with Holt-Oram syndrome at birth. Since she had complex congenital heart disease, chronic heart failure, and severe hypoxia, the risk surrounding surgery to remove the primary tumor was predicted to be very high, and subsequently, chemotherapy was performed. The patient was not able to continue chemotherapy due to adverse effects. However, for one year, both her hypertension and catecholaminedependent symptoms were well controlled by an alpha-adrenergic and beta-adrenergic receptor blockade, although the patient did experience high plasma norepinephrine levels. To our knowledge, this is the first report of a patient with the combination of malignant pheochromocytoma and Holt-Oram syndrome. A correlation between chronic hypoxia and pheochromocytoma has been reported. This instructive case reminds us to consider the possibility of pheochromocytoma with congenital heart disease when these types of unexpected or unusual symptoms are encountered.

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Acutely Exacerbated Hypertension and Increased Inflammatory Signs Due to Radiation Treatment for Metastatic Pheochromocytoma.

Cited by 23 publications

References 19 publications

Paraganglioma of the thoracic spine

Paraganglioma of the thoracic spine

The diagnosis and management of malignant phaeochromocytoma and paraganglioma

A Case of Malignant Pheochromocytoma with Holt-Oram Syndrome

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