Acutely Administered Haloperidol-lnduced Pattern Changes of Regional Cerebral Blood Flow in Schizophrenics

Jibiki, Itsuki; Yamaguchi, Nariyoshi; Kurokawa, Kenzo; Hisada, Kinichi

doi:10.1159/000118834

Cited by 7 publications

(2 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Finally, the formation of additional cognitive contents, especially of the higher order, cannot be easily correlated with brain damage. The last argument is mainly supported by case analysis of delusions induced by psychoactive substances or the occurrence of delusions associated with hypermetabolism or hyperperfusion of certain parts of the brain [14,15].…”

Section: Model Of the Left Hemisphere Releasementioning

confidence: 99%

Usefulness of models in the process of qualifying contents as delusional – case analysis

Janík¹,

Biegańska²

2015

Arch Psych Psych

View full text Add to dashboard Cite

SummaryAim: The purpose of this study was to attempt to apply a two-factor diagnostic model for delusional content qualification. Method: This is a case study of a patient with a history of ischaemic stroke who developed delusional beliefs. Results:The two-factor diagnostic model has shown promising applicability in the case analysed, however, guidance is provided on the need to expand and change some of the criteria with the possibility of complementing the model with elements from neurobiological models. Conclusions:The case analysis allowed us to point out the strengths and weaknesses of the diagnostic model discussed. We propose that strictly neurobiological diagnostic categories should be replaced by those that allow the diagnosis of cognitive deficits. We also hypothesise that problems with inference, as one of the main factors contributing to delusions, should not be analysed only in terms of the damage to the right hemisphere. delusions / delusional models / diagnostic clues / case studyThis article analyses the usefulness of several models of delusions described in the literature in the diagnostic process of a patient with a history of ischaemic stroke affecting the right hemisphere. Previous studies hypothesised on the process of delusional content formation and verified the delusional contents using available diagnostic procedures. Creating models to explain how certain disorders develop has two main advantages: it shows how a specific disorder forms and indicates the main types of factors involved in this process. Thus, it enables a better understanding of the essence of the disorder and helps formulate diagnostic guidelines.Models of this type can have various forms: from a simple presentation of a causal relationship between a factor and a disorder to complex, multifactorial network models, in which each element can potentially interact with the other. The task of theoretical models of delusions will be to indicate the main factors necessary for the emergence of delusional beliefs and to describe the dynamics of the process leading from these factors to delusion formation. The need to create such models primarily stems from a strong internal differentiation within the category of beliefs determined as delusions. Due to this heterogeneity, it is diagnostically interesting to identify and differentiate such factors depending on the contents of delusions.

show abstract

Section: Model Of the Left Hemisphere Releasementioning

confidence: 99%

Usefulness of models in the process of qualifying contents as delusional – case analysis

Janík¹,

Biegańska²

2015

Arch Psych Psych

View full text Add to dashboard Cite

show abstract

“…The findings about the effects of neuroleptics on rCBF are contradictive. Some studies 15 suggest that neuroleptics increases global mean perfusion, but others 16,17 do not. The effect of neuroleptics could not explain the findings of EEG and SPECT, which should be regarded as a reflection of BZ dependence and withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Chronic high‐dose nitrazepam dependence ¹²³I‐IMP SPECT and EEG studies

et al. 2001

View full text Add to dashboard Cite

A patient who took 50-100 mg nitrazepam per day for 25 years is presented. (123)I-IMP SPECT (autoradiography method) and EEG were performed sequentially on the subject during and after the withdrawal syndrome. Severe hypoperfusion of the whole brain on SPECT and diffuse slow activity on EEG were demonstrated during the withdrawal syndrome and subsequently remarkably improved. However, the hypofrontal pattern on both early and delayed images in SPECT was unchanged. The changes observed on SPECT and EEG reflect the pathophysiology of dependence and withdrawal. Additionally, the hypofrontal pattern remained unchanged suggesting that organic brain damage can develop as a result of chronic high-dose benzodiazepine abuse.

show abstract

„Frontale Hypoperfusion“ mittels SPECT bei schizophrener Minussymptomatik

Broich

Kasper

Dános

et al. 1994

Fortschritte in Der Diagnostik Und Therapie Schizophrener Minussymptomatik

View full text Add to dashboard Cite

Acutely Administered Haloperidol-lnduced Pattern Changes of Regional Cerebral Blood Flow in Schizophrenics

Cited by 7 publications

References 8 publications

Usefulness of models in the process of qualifying contents as delusional – case analysis

Usefulness of models in the process of qualifying contents as delusional – case analysis

Chronic high‐dose nitrazepam dependence ¹²³I‐IMP SPECT and EEG studies

„Frontale Hypoperfusion“ mittels SPECT bei schizophrener Minussymptomatik

Contact Info

Product

Resources

About

Acutely Administered Haloperidol-lnduced Pattern Changes of Regional Cerebral Blood Flow in Schizophrenics

Cited by 7 publications

References 8 publications

Usefulness of models in the process of qualifying contents as delusional – case analysis

Usefulness of models in the process of qualifying contents as delusional – case analysis

Chronic high‐dose nitrazepam dependence 123I‐IMP SPECT and EEG studies

„Frontale Hypoperfusion“ mittels SPECT bei schizophrener Minussymptomatik

Contact Info

Product

Resources

About

Chronic high‐dose nitrazepam dependence ¹²³I‐IMP SPECT and EEG studies