Acute Vision Loss as the Only Sign of Leukemia Relapse

Abstract

At first sign of vision loss or ocular symptoms in a patient with a history of lymphoblastic leukemia, and regardless of the hematological findings, exhaustive ophthalmologic exploration and ocular biopsy should be performed without delay-this being crucial for clinical decision making because a prompt diagnosis improves the chances of survival.

Quantitative polymerase chain reaction test for molecular diagnosis of intraocular relapse of acute lymphoblastic leukemia: a case report

“…10 Several case reports described using flow cytometry and qPCR to diagnose intraocular infiltration of leukemia. 11,12 The success of cytological examination and flow cytometry depends on obtaining sufficient leukemic cells for detection. Some recommend >10 mL of cerebrospinal fluid, which is not feasible for aqueous aspirate assuming that affected aqueous humor has similar cell counts to cerebrospinal fluid.…”