Acute Viral Encephalitis

Miller, James R.; Harter, Donald H.

doi:10.1016/s0025-7125(16)32328-8

Cited by 12 publications

(2 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the magnitude of DNA viruses in central nervous system disease has not been defined (10), the following information illustrates the extent to which HSV may be involved. Recent reviews (5,6) HSV as a common cause of sporadic fatal encephalitis and acute necrotizing encephalitis (1).…”

Section: Discussionmentioning

confidence: 99%

“…Both idoxuridine and cytosine arabinoside have failed to significantly influence encephalitis in humans (5,8,10,13,15), and trials with ara-A are not completed. In experimental animal models, ara-A has demonstrated the greatest potential for treatment of herpesvirus-induced encephalitis (16-18, 20, 21), although the relative insolubility of this nucleoside has hampered its intravenous (i.v.)…”

mentioning

confidence: 99%

See 1 more Smart Citation

Inhibition of Experimental Deoxyribonucleic Acid Virus-Induced Encephalitis by 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate

Allen¹,

Thompson²,

Huffman³

et al. 1975

Antimicrob Agents Chemother

View full text Add to dashboard Cite

9-β- d -Arabinofuranosylhypoxanthine 5′-monophosphate (ara-HxMP) significantly controlled the development of encephalitis produced by deoxyribonucleic acid viruses in mice. In most experiments the activities of ara-HxMP and 9-β- d -arabinofuranosyladenine (ara-A) were determined simultaneously. In the intracerebral (target organ) and intravenous therapy experiments, ara-HxMP had a pronounced advantage over ara-A since the water solubility of ara-HxMP enabled it to be used in much higher concentrations. In experiments where the two drugs were administered intraperitoneally or orally they exhibited similar activity. In several intraperitoneal therapy experiments ara-HxMP was tested alone, using various treatment schedules and dosages. In these experiments, efficacy was observed in groups that had treatments initiated as late as 72 h after virus inoculation.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Inhibition of Experimental Deoxyribonucleic Acid Virus-Induced Encephalitis by 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate

Allen¹,

Thompson²,

Huffman³

et al. 1975

Antimicrob Agents Chemother

View full text Add to dashboard Cite

show abstract

Herpes Simplex Encephalitis

Whitley¹

1982

JAMA

284

View full text Add to dashboard Cite

Continuing evaluations of antiviral agents for treatment of herpes simplex encephalitis (HSE) provided an opportunity to collect clinical data from 113 patients in whom the diagnosis was proved by viral isolation. Occurrence of HSE was in all ages and in both sexes and was nonseasonal. Characteristically, patients had behavioral changes, fever, confusion, speech disturbances, and, less frequently, seizures. The EEG was the most useful neurodiagnostic aid followed by technetium and computed axial tomographic scans. Employing a logistic regression model for variable selection, the diagnosis could be predicted by clinical findings and neurodiagnostic tests in 83% of the proved cases, but the evidence in 25% was falsely positive. There was evidence of localization by either clinical or neurodiagnostic assessment in all patients with proved disease. Among patients wtih negative findings for HSE, similar focal findings predominated in all but a few. The CSF and brain scans were normal in many patients with proved HSE. This extensive clinical experience in patients wtih diagnosis proved by viral isolation shows that diagnosis cna be confirmed only by brain biopsy.

show abstract

Cerebrospinal Fluid Alterations Associated with Central Nervous System Infections

Labadie

1980

Neurobiology of Cerebrospinal Fluid 1

View full text Add to dashboard Cite

Acute Viral Encephalitis

Cited by 12 publications

References 64 publications

Inhibition of Experimental Deoxyribonucleic Acid Virus-Induced Encephalitis by 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate

Inhibition of Experimental Deoxyribonucleic Acid Virus-Induced Encephalitis by 9-β- d -Arabinofuranosylhypoxanthine 5′-Monophosphate

Herpes Simplex Encephalitis

Cerebrospinal Fluid Alterations Associated with Central Nervous System Infections

Contact Info

Product

Resources

About