Acute Urticaria in Infancy and Early Childhood

Mortureux, P.; Léauté‐Labrèze, Christine; Legrain-Lifermann, V.; Lamireau, T.; Sarlangue, J.; Taı̈eb, Alain

doi:10.1001/archderm.134.3.319

Cited by 166 publications

(114 citation statements)

References 18 publications

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“…Harris et al [4] found a recovery rate of 58% in 94 children with CU after a 1-year follow-up. Mortureux et al [19] reported a recovery rate of 94.7% in 57 children, most of whom had acute urticaria. Kauppinen et al [18] reported a 47% recovery rate with a mean follow-up of 3.8 years, with physical urticaria having the worst prognosis.…”

Section: Discussionmentioning

confidence: 99%

“…CU can cause significant morbidity in the form of school absences, low school performance, and poor quality of life, and patients rely heavily upon healthcare services compared to patients with other allergic diseases [14]. However, information about the natural course of the disease is drawn mainly from adult studies [15,16,17], and there is little information available regarding children [4,18,19]. …”

Section: Introductionmentioning

confidence: 99%

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Chronic Urticaria: Etiology and Natural Course in Children

Şahiner¹,

Civelek²,

Tuncer³

et al. 2011

Int Arch Allergy Immunol

123

116

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Background: Chronic spontaneous urticaria (CSU) in childhood is infrequent, and information about the disease in children is limited. We attempted to investigate its etiologic factors, natural course, and predictors of prognosis. Methods: All children aged ≤18 years followed for CSU during an 8-year period were analyzed retrospectively, and the final outcomes were queried via a telephone interview. Results: One hundred patients (male/female ratio 1.27) with a median age of 9.2 years (range 0.7–17.2) at symptoms onset were evaluated. The median follow-up was 2.5 years (range 0.2–18.1). An autologous serum skin test was positive in 46.7% of the subjects (n = 45), with a female predominance (71.4%) (p = 0.023). In 13.8% of the children, ANA titers were over 1/100. Food allergy (n = 1), thyroid autoantibodies (n = 3), possible collagen disease (n = 1), and drug usage (deferoxamine) (n = 1) were found to be associated factors. Infections could not be confirmed as the cause of CSU. Recovery was seen in 16.5, 38.8, and 50.0% of the children after 12, 36, and 60 months, respectively. Though in multivariate analysis none of the factors, including age, gender, autologous serum skin test positivity, the presence of angioedema, or other allergic diseases, appeared to predict the prognosis, in univariate analysis being female and being older than 10 years of age predicted an unfavorable prognosis. Conclusion: The etiology of CSU in children is mainly related to an autoreactive background, as in adults. CSU has a favorable prognosis, and resolution is seen in half of the children within 5 years. Girls older than 10 years may have an unfavorable prognosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chronic Urticaria: Etiology and Natural Course in Children

Şahiner¹,

Civelek²,

Tuncer³

et al. 2011

Int Arch Allergy Immunol

123

116

View full text Add to dashboard Cite

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“…Known etiologies of chronic urticaria in children vary from 21% to 83% (3)(4)(5)(6). Infectious causes of chronic urticaria are more common in children than adults (5,7). The association between Helicobacter pylori (H. pylori) and urticaria can be considered as another cause of disease (8)(9)(10).…”

Section: Contextmentioning

confidence: 99%

Omalizumab (Xolair) in Children above 12 Years With Chronic Urticaria: A Review of Literature

Ghaffari¹,

Shahmohammadi²,

Ashrafi³

et al. 2015

J Pediatr Rev

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Generally, 15-25% of general population experience urticaria during their life. The prevalence of chronic urticaria is about 0.1-0.3% in children and most often occurs between ages of 6-11 years. There are several causes for development of chronic urticaria. Known etiologies of chronic urticaria in children vary from 21% to 83%. Chronic urticaria caused by infections is more common in children than adults. Diagnosis of chronic urticaria is based on clinical history and physical examination and routine laboratory testing in the absence of a clinical history is rarely helpful. Similar to adults, antihistamines are the first line of treatment. Omalizumab as a biological engineering molecule is a recombinant humanized monoclonal antibody, which targets the CH3 domain of the ε chain of the free IgE. Omalizumab has been used in patients with H1-antihistamine-refractory chronic idiopathic urticaria (CIU). Here in we made a review about possible mechanisms by which omalizumab may be effective in children above 12 years with chronic urticaria, and also focused on its therapeutic effects, onset criteria and possible side effects.

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“…Yiyecek alerjileri de (özellikle inek sütü) erişkinlere göre çok daha yaygın bir sebeptir. 3,4 Akut ürtikerde atakların kısa sürmesi ve kendini sınırlayan tek bir atak olması nedeniyle bazı otörler etyolojiyi araştırmak için geniş tetkikler yapılmasını önermemektedir. 5 Bu çalışmada akut ürtiker hastalarının ayrıntılı klinik ve demografik özellikleri incelenmektedir.…”

Section: Gi Riflunclassified

Akut Ürtikerli Yatan Hastaların Klinik Olarak Değerlendirilmesi

Karadağ¹,

Bilgili²,

Çalka³

et al. 2011

Turkderm

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ÖzetAmaç: Yatırarak takip ettiğimiz akut ürtikerli ve anjioödemli hastaların klinik ve etyolojik özelliklerinin belirlenmesi ve laboratuvar tetkiklerinin gerekliliğinin değerlendirilmesi. Gereç ve Yöntem: Bu çalışmaya yatırarak tedavi ettiğimiz 105 akut ürtiker ve anjioödemli hasta alındı. Lezyonların özellikleri ve hastaların klinik özellikleri sorgulandı. Ayrıca lezyon sayısı, şiddeti ve ürtika plak çapı kaydedildi. Hastalardan rutin hematolojik ve biyokimyasal tetkikler, tiroid fonksiyon testleri, hepatit belirteçleri, gaytada parazit, total IgE, kültürler, eritrosit sedimantasyon hızı, C-Reaktif protein, antinükleer antikor, PA akciğer grafisi ve gerekli hastalarda psikiyatri konsultasyonu istendi. Bulgular SPSS 15,0 istatistik programına kaydedildi ve yüzde (%) verilerek yazıldı. Bulgular: Hastalarımızın 28'i sadece ürtiker (%26,7), 7'si sadece anjioödem (%6,7), 70'i ürtiker ve anjioödemdi (%66,7). Eşlik eden en sık semptom kaşıntı (%91,4) ve yanma hissi (%34,3) idi. En sık sistemik semptom olarak %15. Sum maryBackground and Design: To determine the clinical and etiological features of inpatients with acute urticaria and angioedema and to assess the need for laboratory tests. Material and Methods:We recruited 105 patients with acute urticaria and angioedema who were admitted to our inpatient unit. The lesions and the characteristics of the patients were analyzed. Routine diagnostic tests including complete blood count, thyroid function tests, hepatitis panel, stool parasite, total IgE levels, cultures, erythrocyte sedimentation rate, C-reactive protein, anti-nuclear antibody, and posterior anterior lung X-ray were ordered. A psychiatric consultation was obtained, when needed. The results were analyzed with SPSS 15.0 statistical software. Results: Among 105 patients, 28 (26.7%) had urticaria, 7 (6.7%) had angioedema, and 70 (66.7%) suffered from both urticaria and angioedema. The most common accompanying symptoms were itching (91.4%) and burning (34.3%). The most common systemic symptoms were fatigue (15.2%) and headache (12.4%). The lesions usually appeared in the evening hours (24.8%). Twenty-five patients were waking up due to itching during the night. Some lesions were associated with physical activities.

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Acute Urticaria in Infancy and Early Childhood

Abstract: To establish the clinical, etiological, and prognostic features of acute urticaria in infancy and early childhood and to define its optimal management.

Cited by 166 publications

References 18 publications

Chronic Urticaria: Etiology and Natural Course in Children

Chronic Urticaria: Etiology and Natural Course in Children

Omalizumab (Xolair) in Children above 12 Years With Chronic Urticaria: A Review of Literature

Akut Ürtikerli Yatan Hastaların Klinik Olarak Değerlendirilmesi

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