Acute Upper Respiratory Tract Infection

Seaton, Douglas

doi:10.1002/9780470695999.ch12

Cited by 10 publications

(10 citation statements)

References 137 publications

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“…A variety of respiratory pathogens can cause similar symptoms in the respiratory tract. Patients with diseases such as the common cold, influenza, and respiratory distress syndromes, are left with the challenge of defining infection agents that may cause cross infections 35 . To study the specificity of our detection system, we evaluated the interference between the target pathogen and other non‐target respiratory viruses.…”

Section: Resultsmentioning

confidence: 99%

Development of a rapid, sensitive detection method for SARS‐CoV‐2 and influenza virus based on recombinase polymerase amplification combined with CRISPR‐Cas12a assay

Wang,

Wu,

et al. 2023

Journal of Medical Virology

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Respiratory tract infections are associated with the most common diseases transmitted among people and remain a huge threat to global public health. Rapid and sensitive diagnosis of causative agents is critical for timely treatment and disease control. Here, we developed a novel method based on recombinase polymerase amplification (RPA) combined with CRISPR‐Cas12a to detect three viral pathogens, including SARS‐CoV‐2, influenza A, and influenza B, which cause similar symptom complexes of flu cold in the respiratory tract. The detection method can be completed within 1 h, which is faster than other standard detection methods, and the limit of detection is approximately 102 copies/μL. Additionally, this detection system is highly specific and there is no cross‐reactivity with other common respiratory tract pathogens. Based on this assay, we further developed a more simplified RPA/CRISPR‐Cas12a system combined with lateral flow assay on a manual microfluidic chip, which can simultaneously detect these three viruses. This low‐cost detection system is rapid and sensitive, which could be applied in the field and resource‐limited areas without bulky and expensive instruments, providing powerful tools for the point‐of‐care diagnostic.

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Section: Resultsmentioning

confidence: 99%

Development of a rapid, sensitive detection method for SARS‐CoV‐2 and influenza virus based on recombinase polymerase amplification combined with CRISPR‐Cas12a assay

Wang,

Wu,

et al. 2023

Journal of Medical Virology

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“…However, when comparing the obtained results to the comparators from the general population (other studies), the indices appear similar. Mean time of declared URTI duration in this study was 8.7 days in the control group, and the average assumed time of an URTI is between 7 and 10 days [ 47 ]. In the Polish population aged 18–45, mean total score of GHQ-28 was determined at 22.9 points, whereas in this study, the average result of the same parameter equalled 22.9 points [21].…”

Section: Discussionmentioning

confidence: 99%

Combined cold-water immersion and breathwork may be associated with improved mental health and reduction in the duration of upper respiratory tract infection - a case–control study

Czarnecki,

Nowakowska-Domagała,

Mokros

2024

International Journal of Circumpolar Health

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A polar plunge is a term referring to an ice-cold water immersion (CWI), usually in the winter period. It is also a part of a specific training program (STP) which currently gains popularity worldwide and was proven to display paradigm-shifting characteristics. The aim of this study was to compare the indices of mental functioning (including depression, anxiety, mindfulness) and duration of upper respiratory tract infection (URTI) measured among the study participants. A set of questionnaires was distributed via the Internet. Participants declaring regular STP practice were selected ( N = 77). Two groups were matched based on a case–control principle: the first one (the control group) comprised participants who did not declare nor CWI practice, nor STP practice. The second one comprised participants declaring regular CWI practice only. The CWI only group displayed better mental health indices and shorter URTIs compared to the control group. Moreover, the STP group also displayed better general mental health, less somatic complaints, and shorter URTIs compared to the CWI only group. This study suggests the existence of CWI’s potential in boosting mental health and immune system functioning, however when complemented by a specific breathwork, this potential can be increased. However, further research is required.

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“…One of the most diagnosed illnesses in adults are upper respiratory tract infections (URTIs), which continue to be a significant cause of social-, economic-and disease burden worldwide. 1 Clinical symptoms, such as coughing, a stuffy or runny nose, and throat irritation, are frequently similar between URTIs, although they are caused by numerous distinct pathogens. Therefore, a definitive diagnosis has to rely on laboratory testing.…”

Section: Introductionmentioning

confidence: 99%

Nasal discharge: A unique enhanced alternative for the detection of respiratory pathogens in adults

Fourie,

Bording,

Euser

et al. 2023

Journal of Medical Virology

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Upper respiratory tract infections are a significant cause of social‐ and disease burden worldwide. Currently, invasive and uncomfortable molecular detection methods are used for respiratory pathogen detection. We aimed to assess the ability and bearability of a rhinorrhea swab (RS) to detect respiratory pathogens in comparison to the combined nasopharyngeal and oropharyngeal swab (NP/OP). This study was performed at a Public Health Service severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) testing facility between November and December 2022 in the Netherlands. Adults aged 16 years and older, being subjected to a standard of care NP/OP swab with nasal discharge, were included and received an additional RS. Respiratory pathogen detection was evaluated using SARS‐CoV‐2 polymerase chain reaction (PCR) and multiplex ligation‐dependent probe amplification (MLPA) PCR. Bearability was evaluated using visual analog scale (VAS) scores and a questionnaire. A total of 100 adults with a mean age ± SD of 46 ± 16 years were included. The NP/OP swab detected 104 pathogens, the RS 83 pathogens (p < 0.001), and in total 108 respiratory pathogens were identified in 89 adults (89%). The ability to detect respiratory pathogens compared between the RS and the combined NP/OP swab revealed a sensitivity of 82% (95% CI 73%–89%) and specificity of 100% (95% CI 72%–100%). RS were significantly more bearable than the combined NP/OP swab (p value < 0.001). Therefore, nasal discharge found in adults can be used as an adequate reliable medium for respiratory pathogen detection using SARS‐CoV‐2 PCR and MLPA PCR.

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Acute Upper Respiratory Tract Infection

Cited by 10 publications

References 137 publications

Development of a rapid, sensitive detection method for SARS‐CoV‐2 and influenza virus based on recombinase polymerase amplification combined with CRISPR‐Cas12a assay

Development of a rapid, sensitive detection method for SARS‐CoV‐2 and influenza virus based on recombinase polymerase amplification combined with CRISPR‐Cas12a assay

Combined cold-water immersion and breathwork may be associated with improved mental health and reduction in the duration of upper respiratory tract infection - a case–control study

Nasal discharge: A unique enhanced alternative for the detection of respiratory pathogens in adults

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