Acute Unilateral Vestibulopathy

Strupp, Michael; Magnusson, Måns

doi:10.1016/j.ncl.2015.04.012

Cited by 103 publications

(76 citation statements)

References 48 publications

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“…The use of even colder water (20°C) and/or the repetition of three caloric tests at each time point may enhance vestibular imbalance and reduce the variability in otherwise healthy volunteers. In our study, despite large inter-and intra-individual variability for all nystagmus and vertigo parameters, as is commonly reported for healthy volunteers [22,23], significant improvements were seen for vertigo appearance, sensation and disappearance with up to 7 days of repeated SENS-111 administrations compared to baseline for most doses evaluated, although no significant changes were seen for nystagmus over time. The absence of an apparent impact for nystagmus may be accounted for by the very high variability and by the fact that this measurement typically only takes into account a few beats around PSV, whereas the other measures are more continuous.…”

Section: Discussionsupporting

confidence: 63%

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Venail

Attali

Wersinger

et al. 2018

Brit J Clinical Pharma

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Section: Discussionsupporting

confidence: 63%

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Venail

Attali

Wersinger

et al. 2018

Brit J Clinical Pharma

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“…dysfunction (4,5). A viral etiology of VN is supported by studies showing inflammatory degeneration of the vestibular nerves and the presence of herpes simplex virus 1 (HSV-1) DNA as well as latency-associated transcript (LAT) in the vestibular ganglia (VG) (6)(7)(8)(9).…”

mentioning

confidence: 99%

Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis

Himmelein

Lindemann

Sinicina

et al. 2017

J Virol

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Controversy still surrounds both the etiology and pathophysiology of vestibular neuritis (VN). Especially uncertain is why the superior vestibular nerve (SVN) is more frequently affected than the inferior vestibular nerve (IVN), which is partially or totally spared. To address this question, we developed an improved method for preparing human vestibular ganglia (VG) and nerve. Subsequently, macro-and microanatomical as well as PCR studies were performed on 38 human ganglia from 38 individuals. The SVN was 2.4 mm longer than the IVN, and in 65% of the cases, the IVN ran in two separate bony canals, which was not the case for the SVN. Anastomoses between the facial and cochlear nerves were more common for the SVN (14/38 and 9/38, respectively) than for the IVN (7/38 and 2/38, respectively). Using reverse transcription-quantitative PCR (RT-qPCR), we found only a few latently herpes simplex virus 1 (HSV-1)-infected VG (18.4%). In cases of two separate neuronal fields, infected neurons were located in the superior part only. In summary, these PCR and micro-and macroanatomical studies provide possible explanations for the high frequency of SVN infection in vestibular neuritis.IMPORTANCE Vestibular neuritis is known to affect the superior part of the vestibular nerve more frequently than the inferior part. The reason for this clinical phenomenon remains unclear. Anatomical differences may play a role, or if latent HSV-1 infection is assumed, the etiology may be due to the different distribution of the infection. To shed further light on this subject, we conducted different macro-and microanatomical studies. We also assessed the presence of HSV-1 in VG and in different sections of the VG. Our findings add new information on the macro-and microanatomy of the VG as well as the pathophysiology of vestibular neuritis. We also show that latent HSV-1 infection of VG neurons is less frequent than previously reported.KEYWORDS HSV-1 latency, human, vestibular ganglia, vestibular neuritis V estibular neuritis (VN) is a common cause of an "acute unilateral vestibulopathy." The main clinical symptoms of VN are acute onset of prolonged severe spinning vertigo with spontaneous horizontal torsional nystagmus toward the unaffected ear, postural imbalance, and nausea (1). Its annual incidence is reported to be 3.5 to 15.5 per population of 100,000 (2, 3). It is the third most common cause of peripheral vestibular

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“…AVS typically presents with the symptoms of new onset continuous vertigo, motion intolerance, gait instability, and nausea/vomiting lasting several days to weeks. [2][3][4][5] The Head Impulse, Nystagmus, and Test of Skew (HINTS) battery test [including a head impulse test (HIT), examination of gaze-evoked nystagmus, and test of skew deviation] is well known as an easily available bedside examination that can better differentiate AUV from central vertigo at the early stage compared to diffusion weighted MRI. 6) Among the tests included in the HINTS battery, horizontal HIT has been established in previous reports as a simple and useful test for evaluating the vestibule-ocular reflex (VOR) with high sensitivity.…”

Section: Introductionmentioning

confidence: 99%

Clinical Application of Video Head Impulse Test in Acute Vestibular Syndrome

Yoo¹

2020

Korean J Otorhinolaryngol-Head Neck Surg

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Acute unilateral vestibulopathy (AUV) is the recommended term [rather than the more widely used 'vestibular neuritis (VN)'] for all pathologies involving sudden impairment of the unilateral peripheral vestibular function regardless of the exact location of the lesion. Acute vestibular syndrome (AVS) is an upper-level entity of AUV, which is the most common cause of AVS, and includes acute central vertigo. AVS typically presents with the symptoms of new onset continuous vertigo, gait instability, and nausea/vomiting lasting several days to weeks. The video head impulse test (vHIT) was recently developed and has been widely adopted at clinics and emergency centers. In this study, we will review the differential diagnosis of AVS using vHIT. In addition, we will describe the subtypes of VN and the use of vHIT for follow-up testing in AVS.

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Acute Unilateral Vestibulopathy

Cited by 103 publications

References 48 publications

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis

Clinical Application of Video Head Impulse Test in Acute Vestibular Syndrome

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Acute Unilateral Vestibulopathy

Cited by 103 publications

References 48 publications

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H4 receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H4 receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Differential Involvement during Latent Herpes Simplex Virus 1 Infection of the Superior and Inferior Divisions of the Vestibular Ganglia: Implications for Vestibular Neuritis

Clinical Application of Video Head Impulse Test in Acute Vestibular Syndrome

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Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects

Safety, tolerability, pharmacokinetics and pharmacokinetic‐pharmacodynamic modelling of the novel H₄ receptor inhibitor SENS‐111 using a modified caloric test in healthy subjects