Acute Tubular Necrosis and Thrombocytopenia Associated With Rifampin Use: Case Report and Review

Smith, Emma L; Bywater, Laura; Pellicano, Rebecca; Jenkin, Grant A.; Korman, Tony M.

doi:10.1093/ofid/ofac258

Cited by 4 publications

(2 citation statements)

References 28 publications

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“…Up to now, there are 22 patients diagnosed with acute renal failure by kidney biopsy due to the use of rifampicin. Most of the patients mentioned were male like our patient [8]. The presence of antibodies linked to rifampicin is mentioned in the etiology.…”

Section: Discussionmentioning

confidence: 67%

Successful Treatment of Tuberculosis Combined With Rifampicin Induced Interstitial Nephritis: A Case Report

ZY¹,

AB²,

Babalık³

2023

Int J Nephrol Kidney Fail

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A 61-year-old man was admitted to our hospital on September 2021 because of a three-month history of fatigue, night sweats, and weight loss. The patient had been diagnosed with organized pneumonia and was treated with methyl prednisolone at a local hospital. One week before presentation to our hospital, he had developed fever, cough, sputum and shortness of breath. Upon admission to our hospital, sputum acid-fast resistant bacteria (ARB) and urine ARB were positive and mycobacterium tuberculosis was cultured. With the diagnosis of drug-sensitive pulmonary and urinary tuberculosis, treatment consisting of isoniazid, rifampicin, ethambutol and pyrazinamide was started. After two months, his symptoms had not improved and he developed nausea and vomiting. At the next visit to our hospital, his renal function tests were further increased. He was taken for emergency dialysis. Diagnosis of interstitial nephritis was made by kidney biopsy, which was considered to have developed due to the use of rifampicin. Rifampicin was discontinued and methyl prednisolone was added. The new drug regimen was arranged as isoniazid, moxifloxacin, ethambutol, pyrazinamide and cycloserine. Cycloserine was discontinued due to tremors and prothionamide was started. When drug-induced hepatitis developed, his subsequent treatment was changed to isoniazid, levofloxacin, ethambutol, and pyrazinamide. The patient was treated with methyl prednisolone for two months. Currently, he has been taking the treatment stated above for 4 months without any problems and it is scheduled to be completed in 12 months.

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Section: Discussionmentioning

confidence: 67%

Successful Treatment of Tuberculosis Combined With Rifampicin Induced Interstitial Nephritis: A Case Report

ZY¹,

AB²,

Babalık³

2023

Int J Nephrol Kidney Fail

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“…In most case series, acute interstitial nephritis is the most frequently associated pathologic finding on biopsy ( 4 – 7 ). However, other patterns, such as acute tubular necrosis, crescentic glomerulonephritis, mesangial proliferation, and minimal change disease, have been noted in case reports ( 5 , 8 , 9 ).…”

Section: Discussionmentioning

confidence: 95%

Rifampin-Associated Renal Failure

2023

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Rifampin is an effective and widely used for the treatment of both active and latent tuberculosis. Although significant side effects are rare, severe side effects such as acute renal failure have been reported in the literature, usually secondary to acute interstitial nephritis. We report a case of rifampin-induced acute renal failure due to heme pigment–related injury in a patient who was receiving daily rifampin as therapy for latent tuberculosis. The patient case illustrates considering rifampin as a potential cause of acute renal failure when no other cause is identified.

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Rifampicin

2022

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Acute Tubular Necrosis and Thrombocytopenia Associated With Rifampin Use: Case Report and Review

Cited by 4 publications

References 28 publications

Successful Treatment of Tuberculosis Combined With Rifampicin Induced Interstitial Nephritis: A Case Report

Successful Treatment of Tuberculosis Combined With Rifampicin Induced Interstitial Nephritis: A Case Report

Rifampin-Associated Renal Failure

Rifampicin

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