Acute transverse myelitis with normal brain MRI

Perumal, Jui; Zabad, Rana; Caon, Christina; MacKenzie, Megan; Tselis, Alexandros; Bao, Fen; Latif, Zahid; Zak, Imad; Lisak, Robert P.; Khan, Omar

doi:10.1007/s00415-007-0686-5

Cited by 28 publications

(13 citation statements)

References 26 publications

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“…In Kira and colleagues' series of 12 patients, no relapses were documented after a mean of approximately 2 years of follow-up 5. In comparison, a recent study of patients with isolated tranverse myelitis and normal MRI brain scans suggests that the vast majority of those patients who convert to MS do so within the first 24 months 8. Further, Kira et al reported the presence of hyper-IgE-aemia to be 63% in unselected cases of unexplained monophasic myelitis compared with 18% in MS and 23% in healthy controls 5.…”

Section: Discussionmentioning

confidence: 96%

Atopic myelitis in a European woman residing in Japan

Isaacs

Bodini

Ciccarelli

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 96%

Atopic myelitis in a European woman residing in Japan

Isaacs

Bodini

Ciccarelli

et al. 2010

Journal of Neurology, Neurosurgery & Psychiatry

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“…Partial myelitis, while still acute or subacute in onset, involves only a partial cross-sectional area of the spinal cord, often manifesting as asymmetric motor or sensory dysfunction, and is the more common form of myelitis observed in MS. Patients presenting with a partial myelitis have a 20-30% transition rate to clinically definite MS at 5-year follow-up, compared to only 2% of complete myelitis patients [64][65][66][67].…”

Section: Diagnosis and Risk Of Clinically Definite Msmentioning

confidence: 91%

A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis

2011

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Although multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS), it lacks any definitive diagnostic test. Instead, diagnosis of MS primarily depends upon clinical criteria, supported by abnormalities characteristic of MS on para-clinical investigations including magnetic resonance imaging of the brain and spine, in the absence of an alternative explanation for underlying neurologic symptoms. While many of the potential disorders that may mimic MS in routine clinical practice are either extremely rare, or associated with specific and characteristic distinguishing diagnostic features, some inflammatory demyelinating disorders of the CNS may be particularly challenging to distinguish from MS, especially during initial presentation. In particular, acute disseminated encephalomyelitis, neuromyelitis optica, and idiopathic transverse myelitis may closely resemble MS, impeding prompt and accurate diagnosis. In this review, we describe the clinical features, diagnosis, pathology, and treatment of these other CNS demyelinating disorders. In addition, we review relevant features of other CNS inflammatory disorders that may mimic MS, including Sjögren's syndrome, systemic lupus erythematosus, Behçet's disease, and primary CNS vasculitis.

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“…4,9,22,23 For example, in the Kaiser Permanente study, females represented 71% of the cases with TM. 8 However, these studies do not control for patients who were ultimately diagnosed with MS, which has a strong female predominance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study

Holroyd

Aziz

Szólics

et al. 2018

Clinical & Exp Neuroim

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Objective To determine the epidemiology and characteristics of transverse myelitis (TM) and neuromyelitis optica spectrum disorders (NMOSD) in Abu Dhabi, United Arab Emirates. Methods Retrospective chart review at four large government-run hospitals in Abu Dhabi between 2010 and 2016. Data collected included year of onset, presentation, laboratory results including aquaporin-4 immunoglobulin G (IgG)/myelin oligodendrocyte glycoprotein IgG antibodies and the occurrence of any relapses. Results A total of 46 individuals were identified. Of these, 23 (50%) were Emirati citizens. Within the overall group including pediatrics, the crude prevalence rate for monophasic TM was 1.0 per 100 000, and for NMOSD was 0.34 per 100 000. Incidence rates within the overall group for TM and NMOSD were 0.18 per 100 000 and 0.05 per 100 000, respectively. For Emirati citizens aged ≥20 years, the prevalence rate for monophasic TM was 2.46 per 100 000 and 1.76 per 100 000 for NMOSD, and the incidence was 0.57 per 100 000 and 0.17 per 100 000, respectively. The incidence of monophasic TM and NMOSD within the Emirati pediatric population (aged ≤19 years) was 0.18 per 100 000 and 0.06 per 100 000, respectively. The mean age of onset for monophasic TM was 36 years, and for NMOSD was 43 years. Nine patients had a positive aquaporin-4 IgG or anti-myelin oligodendrocyte glycoprotein IgG antibody result. Of the 30 participants with available laboratory cerebrospinal fluid analysis, 36.6% had elevated white blood counts (>5.0 × 106/L), and 43% had elevated protein levels. A total of 19 participants had documentation of oligoclonal bands or IgG index, and just four (21%) had either oligoclonal bands or elevated IgG index. Conclusion The present study describes the epidemiology and characteristics of TM and NMOSD among populations in Abu Dhabi. The adult prevalence rate for Emirati citizens was 2.46 per 100 000 for monophasic TM, and 1.76 per 100 000 for NMOSD. The overall incidence was 0.18 per 100 000 and 0.05 per 100 000, respectively.

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Acute transverse myelitis with normal brain MRI

Cited by 28 publications

References 26 publications

Atopic myelitis in a European woman residing in Japan

Atopic myelitis in a European woman residing in Japan

A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis

Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study

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