Acute Transverse Myelitis Associated With Human Parvovirus B19 Infection

Suzuki, Masashi; Yoto, Yuko; Ishikawa, Aki; Asakura, Hirofumi; Tsutsumi, Hiroyuki

doi:10.1177/0883073813499824

Cited by 5 publications

(1 citation statement)

References 12 publications

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“…No B19V pneumonia was diagnosed among our patients. Concerning neurological injury, B19V‐associated acute myelitis has been reported in two previous case reports among immunocompetent patients, 25,26 but our case if the first report in an alloHSCT recipient. In our patient, the chronological link between neurological symptoms and reticulocytopenia, as well as the high B19V PCR positivity in both blood and CSF argue in favor of its pathogenicity.…”

Section: Discussionmentioning

confidence: 55%

Clinical and immune features of human parvovirus B19 infection in allogeneic stem cell transplantation recipients: A retrospective monocentric study

Sammut,

Feghoul,

Xhaard

et al. 2023

Transplant Infectious Dis

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BackgroundHuman parvovirus B19 (B19V) infection is associated with pure red cell aplasia (PRCA) in immunocompromised patients; however, the spectrum of manifestations associated with B19V in allogeneic hematopoietic stem cell transplantation recipients (alloHSCT) has rarely been reported.MethodsIn this study, we aimed to report clinical and immune features of B19V infection after alloHSCT. We retrospectively collected and analyzed clinical and microbiological data of all transplanted patients with B19V DNAmia or tissue infection detected by polymerase chain reaction (PCR) in our center from 2010 to 2021.ResultsWe report 35 cases of B19V infections in 33 patients. Median time from transplant to B19V first PCR positivity was 6.9 months (interquartile range (IQR) [1.6–18.9]). No preferential immune profile, type of transplantation or conditioning was identified. Hematological impairment was the most frequent sign, followed by rash and fever. Unconventional clinical forms were also detected, such as acute myelitis and myositis. For some cases, the direct relationship between symptoms and B19V infection was difficult to prove but was suggested by targeted tissue PCR positivity. When hematological impairment was not at the forefront, reticulocytopenia helped to diagnose B19V infections. Treatment was mainly based on high dose intravenous immunoglobulin.ConclusionAlthough hematological impairment was the most frequent sign, B19V can affect multiple targets and lead to atypical manifestations. Because of its heterogeneous clinical presentation, B19V infection is likely under‐diagnosed. Diagnosis of unusual B19V organ involvement needs combination of arguments which can include targeted tissue PCR. image

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Section: Discussionmentioning

confidence: 55%