Acute Transient Hemolytic Anemia with a Positive Donath-Landsteiner Test Following Parvovirus B19 Infection

Chambers, Linda A.; Rauck, A. M.

doi:10.1097/00043426-199605000-00017

Cited by 19 publications

(6 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The influence of the environmental conditions on infectious diseases that do not require a vector, and direct effects of the environment on the immune system itself could also cause the incidence to vary with season in some regions and not others. For example, parvovirus, is associated with IMHA in people, and the incidence of canine parvovirus is seasonal . Geographic differences in the incidence of underlying infection is hypothesized to contribute to the regionally variable seasonality of immune‐mediated diseases such as inflammatory bowel disease and Guillain‐Barre syndrome in people …”

Section: Discussionmentioning

confidence: 99%

Seasonality of immune‐mediated hemolytic anemia in dogs from southern California

Kidd

Rasmussen

Chaplow

et al. 2014

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Seasonality of immune‐mediated hemolytic anemia in dogs from southern California

Kidd

Rasmussen

Chaplow

et al. 2014

J Vet Emergen Crit Care

View full text Add to dashboard Cite

show abstract

“…A variety of infections, including parvoviral infection, can induce RBC hemolysis (25), releasing potentially toxic free hemoglobin into the serum. Activation of haptoglobin from its pro form allows free hemoglobin molecules to be sequestered in hemoglobin:haptoglobin complexes and cleared from the circulation (26).…”

Section: Discussionmentioning

confidence: 99%

Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats

Kruger

Yang

Tam

et al. 2010

Exp Biol Med (Maywood)

View full text Add to dashboard Cite

Proteomic profiling of serum is a powerful technique to identify differentially expressed proteins that can serve as biomarkers predictive of disease onset. In this study, we utilized 2D gel analysis followed by MALDI-TOF mass spectrometry analysis to identify putative serum biomarkers for autoimmune type 1 diabetes (T1D) in BioBreeding Diabetes Resistant (BBDR) rats induced to express disease. Treatment with toll-like receptor 3 (TLR3) ligand, polyinosinic:polycytidilic acid (pIC), plus infection with Kilham rat virus (KRV), a rat parvovirus, results in nearly 100% of young BBDR rats becoming diabetic within 11–21 days. Sera collected from pre-diabetic rats at early time points following treatment with pIC + KRV were analyzed by 2D gel electrophoresis and compared with sera from control rats treated with PBS, pIC alone, or pIC + H1, a non-diabetogenic parvovirus. None of the latter three control treatments precipitates T1D. 2D gel analysis revealed that haptoglobin, an acute phase and hemoglobin scavenger protein, was differentially expressed in the sera of rats treated with pIC + KRV relative to control groups. These results were confirmed by Western blot and ELISA studies that further validated haptoglobin levels as being differentially increased in the sera of pIC + KRV treated rats relative to controls during the first week following infection. Early elevations in serum haptoglobin were also observed in LEW1.WR1 rats that became diabetic following infection with rat cytomegalovirus (RCMV). The identification and validation of haptoglobin as a putative serum biomarker for autoimmune T1D in rats now affords us the opportunity to test the validity of this protein as a biomarker for human T1D, particularly in those situations where viral infection is believed to precede onset of disease.

show abstract

“…20 Although we would now expect to see three to four cases of PCH in 1 year, our experience and that of others is that they often present in small clusters; sometimes two or three occur close together, and at other times, long periods pass without a case being referred. 8,21,22 Paroxysmal cold hemoglobinuria is typically associated with infection 7,10,12,[23][24][25] and this was evident, or implied by the antibiotic treatment, in three of the four patients.There are several case reports of the disease following specific illnesses, including measles, 13 measles immunization, 10 parvovirus, 24 mumps, 25 Klebsiella pneumonia, 12 chicken pox, 7 and upper respiratory tract infections. 7,14,20,26 The condition is most commonly encountered in a severe acute transient form, as in the present cases, and has been the subject of an excellent review.…”

Section: Discussionmentioning

confidence: 94%

Paroxysmal cold hemoglobinuria and the elusive Donath- Landsteiner antibody

Sokol¹,

Booker²,

Stamps³

1998

Immunohematology

View full text Add to dashboard Cite

Four patients with paroxysmal cold hemoglobinuria (PCH) illustrate some of the difficulties in making the diagnosis. A 46-year-old male presented with anemia, a weakly positive direct antiglobulin test (DAT) with anti-IgG, a haptoglobin < 0.1 g/L, and a cold autoagglutinin showing anti-P specificity. A 9-year-old female had a 4-day coryzal illness, a 20 g/L fall in hemoglobin over 24 hours, and a haptoglobin < 0.1 g/L; the DAT was positive with anti-C3d. A 3-year-old female was referred following a rapid drop in hemoglobin of 30 g/L; the DAT was positive with anti-C3d. A 17-month-old female, unwell for 2 weeks, had a hemoglobin of 41 g/L; the DAT was strongly positive with anti-C3d and weakly positive with anti-IgG and -C3c. In all patients, PCH was confirmed by positive indirect Donath-Landsteiner tests, and the autoantibodies demonstrated P specificity. In two patients, the test was strongly positive; in the third patient, it was only positive using papainized red cells; and in the fourth patient, a two-stage papainized procedure was needed before a positive result was obtained. PCH must always be considered in a child with a rapid drop in hemoglobin, even if initial tests are negative. Immmunohematology 1998;14:109-112.

show abstract

Acute Transient Hemolytic Anemia with a Positive Donath-Landsteiner Test Following Parvovirus B19 Infection

Cited by 19 publications

References 18 publications

Seasonality of immune‐mediated hemolytic anemia in dogs from southern California

Seasonality of immune‐mediated hemolytic anemia in dogs from southern California

Haptoglobin as an early serum biomarker of virus-induced autoimmune type 1 diabetes in biobreeding diabetes resistant and LEW1.WR1 rats

Paroxysmal cold hemoglobinuria and the elusive Donath- Landsteiner antibody

Contact Info

Product

Resources

About