Acute toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Koutchiko, Angelus Henok Segla; Attakpa, Selidji Eugene; Akotegnon, Rodrigue; Guinnin, Félix F.D.; Sènou, Maximin; Amoussa, Abdou Madjid O.; Lagnika, Latifou; Sina, Haziz; Yedomonhan, Hounnankpon; Baba-Moussa, Farid; Sèzan, Alphonse; Baba-Moussa, Lamine

doi:10.5897/jpap2021.0143

Cited by 3 publications

(2 citation statements)

References 27 publications

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“…Thus, these significant decreases in PLT# might have led to the observed mortalities possibly due to impairment of blood coagulation molecules by the compounds contained in CDE. In contrast, others studies on Croton species such as C. gratissimus extract was reported to cause significant increase in platelets (PLT) in the treated rats (Koutchiko et al 2022), while the PLT# of rats administered Maerua classifolia was not affected (Christian et al 2017).…”

Section: Discussionmentioning

confidence: 92%

“…The observed significant decreases in haematocrit and PLT# of mice following administration of CDE might be the reason for the observed mice mortalities at the corresponding doses. It is known that, thrombocytes play a major role in homeostasis and immunity in both innate and adaptive immune responses (Koutchiko et al 2022, Silva-Santana et al 2020 as well as in preventing bleeding due to injuries. Thus, these significant decreases in PLT# might have led to the observed mortalities possibly due to impairment of blood coagulation molecules by the compounds contained in CDE.…”

Section: Discussionmentioning

confidence: 99%

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Anticancer Potential of the Leaf Extracts from the Selected Croton Species

Fayyu,

Munissi,

Nyandoro

et al. 2023

Tanz. J. Sci.

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The reported investigations were aimed at establishing anticancer potential of the leaf extracts from Croton dictyophlebodes (CDE), C. kilwae (CKE) and C. longipedicellatus ssp austrotanzanicus (CLE). In vitro cytotoxicity assays of the extracts were performed against human laryngeal cancer cell line (HEp-2) and human breast cancer cell line (MCF-7), while in vivo toxicological studies were done using Swiss albino mice (Mus musculus) following the Organization for Economic Cooperation and Development guideline number 423 of 2001. Results for in vitro assays revealed that CDE and CLE induced cytotoxicity to MCF-7 and HEp-2 cell lines at EC50 values of 86 and 63 µg/mL, respectively, while CKE was inactive to HEp-2 cells at 100 µg/mL. For in vivo studies, mice were given calculated doses based on globally harmonized standards and monitored for 14 days to observe signs of toxicity. Haematological analysis was also carried out to obtain information on changes in blood conditions. The findings showed that LD50 for CKE and CDE were > 2000 mg/kg, while for CLE was 175 mg/kg body weight (b.w.). The oral administration of CDE and CKE did not reveal significant changes in haematological parameters of treated mice, while CLE provoked some. Thus, the studied extracts may be considered potential cancer remedies with safety pre-cautions that warrant further investigations.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Anticancer Potential of the Leaf Extracts from the Selected Croton Species

Fayyu,

Munissi,

Nyandoro

et al. 2023

Tanz. J. Sci.

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Proximate Analysis of Nigerian Croton Gratissimus, Croton Lobatus, Croton Membranaceus and Croton Penduliflorus

Adamu,

Atanda,

Al-Adams

et al. 2024

FJS

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With about 1300 species of herbs, shrubs, trees, and lianas, Croton (Euphorbiaceae) is one of the largest genera of flowering plants. It is an important component of secondary vegetation in the tropics and subtropics of the world and has ecological significance. The growing consumer interest in ingredients originating from natural sources has led to a recent surge in the demand for natural extracts in the food, cosmetics, and pharmaceutical industries. Determining the proximate analysis of Croton gratissimus, lobatus, memebranaceus, and penduliflorus stembarks is the aim of this work. The proximate analysis was carried out using AOAC standard procedures in order to assess the moisture contents, dry matters, crude proteins, ash contents, carbohydrates, fat contents and fiber contents of the stated plant materials. The findings showed that there was a significant amount of dry matter, fiber and carbohydrates at 82.52%, 32.48% and 38.63% respectively in the stem bark of Croton gratissimus. Croton lobatus showed the highest amount of protein and fat content at 17.83% and 4.71% respectively while Croton lobatus and penduliflorus contains the same amount of moisture at 24.53%. Findings of the study showed that the stembarks of the plants possess high nutritional value.

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Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

Agbodjento

Lègba

Dougnon

et al. 2023

Plants

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Medicinal plants play a crucial role in the primary health care of the population in developing countries such as Benin. The national universities of Benin conduct research on the pharmacological, toxicological, and phytochemical properties of these plants, but the resulting knowledge often does not lead to the development of phytomedicines for the improvement of public health. This study aims to assess the current status of research on medicinal plants in Benin. A literature review was conducted using various search engines, and the collected data was analyzed. The results indicate that research on the biological properties of medicinal plants is still in its early stages, with limited and inadequate methodological approaches. These limitations highlight the urgent need to enhance research practices and facilitate the development of effective and safe phytomedicines.

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Acute toxicity profile of ethanolic extracts of Croton gratissimus Burch and Schrankia leptocarpa DC in rats: Medicinal plants used in the treatment of arterial hypertension in Beninese traditional medicine

Cited by 3 publications

References 27 publications

Anticancer Potential of the Leaf Extracts from the Selected Croton Species

Anticancer Potential of the Leaf Extracts from the Selected Croton Species

Proximate Analysis of Nigerian Croton Gratissimus, Croton Lobatus, Croton Membranaceus and Croton Penduliflorus

Unleashing the Potential of Medicinal Plants in Benin: Assessing the Status of Research and the Need for Enhanced Practices

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