Acute toxicity of tributyltin to selected Chesapeake Bay fish and invertebrates

Bushong, Steven J.; Hall, Lenwood W.; Hall, W. S.; Johnson, Warren E.; Herman, Roger L.

doi:10.1016/0043-1354(88)90150-9

Cited by 66 publications

(26 citation statements)

References 12 publications

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“…The fourday LC50 for another marine amphipod (Gammarus sp.) was 4.5 nM (1.3 #g TBT/L) for young and 18 nM (5.3,ug/L) for adults (Bushong et al, 1990a), demonstrating the same age effect seen in Hyalella (Table 1).…”

Section: Discussionmentioning

confidence: 51%

“…Shrimp were less sensitive to TBT but marine copepods were more sensitive (3-d LC50 = 2 nM (0.5-0.6 #g TBT/L)) for Eurytemora affinis, Bushong et al, 1990a). Significant mortality has been reported in the marine copepod Acartia tonsa at concentrations as low as 0.08 nM (0.023 #g TBT/L, Bushong et al, 1990b).…”

Section: Discussionmentioning

confidence: 99%

“…Significant mortality has been reported in the marine copepod Acartia tonsa at concentrations as low as 0.08 nM (0.023 #g TBT/L, Bushong et al, 1990b). Four-day LC50s for marine fish ranged from 16 to 90 nM (4.5 to 26/zg TBT/L, Bushong et al, 1990a). The 4-day LC50 for rainbow trout was 12 nM (1.4 #g Sn/L) and for lake trout was 44 nM (5.2/zg Sn/L).…”

Section: Discussionmentioning

confidence: 99%

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The relationship between tribuyltin (TBT) accumulation and toxicity to Hyalella azteca for use in identifying TBT toxicity in the field

Borgmann

Chau

Wong

et al. 1996

J Aquat Ecosyst Stress Recov

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The relationship between bioaccumulation and toxicity of tributyltin in Hyalella azteca was determined for future use in identifying freshwater sites of TBT induced toxicity in the field. Hyalella accumulated waterborne TBT rapidly, reaching equilibrium within 1 week. Short exposure times are, therefore, sufficient to measure TBT availability in laboratory or field exposures. Accumulation was not affected significantly by body size for animals between 0.1 and 0.6 mg dry weight, eliminating the need for a body size correction factor. Young amphipods were more sensitive to TBT than adults when both were exposed for 1 week. The 4-wk LC50 initiated with 0-1-week-old young was 4.8 nM. TBT accumulation was approximately proportional to TBT in water, and the 4-week LC50 expressed on a body concentration basis was 110 nmole/g dry weight. Accumulation of TBT by adult Hyalella to concentrations of about 100 nmole/g or more during short term (1-wk) exposures to environmental samples would suggest chronic TBT-induced toxicity is present at those sites.

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Section: Discussionmentioning

confidence: 51%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The relationship between tribuyltin (TBT) accumulation and toxicity to Hyalella azteca for use in identifying TBT toxicity in the field

Borgmann

Chau

Wong

et al. 1996

J Aquat Ecosyst Stress Recov

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“…In this study, TBT concentrations of 20 µg/L or greater induced body axis distortion and degeneration of the tip of the tail fin bud, followed by histological alterations in the trunk muscle and skin degeneration, suggesting that these effects could be common for all fish larva. On the other hand, the LC 50 value of TBT was 3.0 µg/L in silverside larva (Menidia beryllina) [1]. Although chemical forms are not always identical, acute LC 50 values have been reported as 5.8 µg/L in rainbow trout larva [3] and as 7.1 µg/L in fathead minnow larva for TPT [16].…”

Section: Discussionmentioning

confidence: 99%

Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish

Wang

Muramoto

Nagai

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. Organotins are among the most common marine pollutants in the world, as they are widely used as antifouling paint on ships and fishing nets. It has been reported that organotin preferentially accumulates in the central nervous system, especially in the retinal neurons of marine organisms including fish. In this study, we investigated the effects of waterborne tributyltin (TBT) on early-stage developing zebrafish (Danio rerio). Below the lethal concentrations, TBT specifically increased the number of apoptotic cells in the retina as well as some cells near trigeminal neurons, detected by terminal transferase-mediated nick-end-labeling staining. Apoptosis peaked at 60 hpf and decreased by 72 hpf, which was associated with macrophage accumulation. Furthermore, the effect of TBT was markedly inhibited by antioxidants, ascorbic acid or trolox. These results suggest that TBT preferentially induces apoptosis in the retinal neuron of developing zebrafish. Oxidative stress may be involved in this toxicological response.

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“…Effects of TBT have been investigated in several aquatic organisms, including algae (Waldock and Thain 1983) and crustaceans (Laughlin et al 1983;Bushong et al 1988;Pinkney et al 1990). Many studies have shown the effect of TBT on growth (Fent and Meier 1994;Bentivegna and Piatkowski 1998) and reproduction (Nirmala et al 1999;Inoue et al 2004;Nakayama et al 2005;Shimasaki et al 2006).…”

Section: Introductionmentioning

confidence: 99%

Impact of tributyltin on antioxidant and DNA damage response in spermatozoa of freshwater prawn Macrobrachium rosenbergii

Rani¹,

Musthafa²,

War³

et al. 2015

Environ Sci Pollut Res

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Effects of tributyltin (TBT) on antioxidant [total superoxide dismutase (SOD), glutathione peroxidase (GPx), and glutathione reductase (GR)] and DNA damage levels in the spermatozoa were studied and reported here for the first time in the freshwater prawn Macrobrachium rosenbergii. Three groups of (n = 10 in each group) fishes were exposed to three different nominal concentrations of TBT viz., 1, 2, and 4 mg L(-1) along with control group for 90 days. Significant decrease of antioxidant and increased DNA damage levels were seen at higher doses of 2 and 4 mg L(-1). In prawn, the antioxidant level plays a vital role in sperm protection, activation, differential functions related to the physiology, and reproductive behavior. This study serves as a biomonitoring tool to assess the TBT effects on reproductive behavior of aquatic biota.

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Acute toxicity of tributyltin to selected Chesapeake Bay fish and invertebrates

Cited by 66 publications

References 12 publications

The relationship between tribuyltin (TBT) accumulation and toxicity to Hyalella azteca for use in identifying TBT toxicity in the field

The relationship between tribuyltin (TBT) accumulation and toxicity to Hyalella azteca for use in identifying TBT toxicity in the field

Retinal Neuronal Cell is a Toxicological Target of Tributyltin in Developing Zebrafish

Impact of tributyltin on antioxidant and DNA damage response in spermatozoa of freshwater prawn Macrobrachium rosenbergii

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