Acute toxicity of plants mixture used in traditional treatment of edema and colic renal in Morocco

Chebaibi, Mohamed; Bousta, Dalila; Chbani, Laïla; zoubi, Yassine Ez; Touiti, Noufissa; Achour, Sanae

doi:10.1016/j.sciaf.2019.e00152

Cited by 13 publications

(12 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moroccan population has used medicinal plants for therapeutic pauses for thousands of years. Moroccans have inherited the phytotherapy knowledge from the previous generation either verbally or written, recorded history [ 6 , 9 ]. Moroccan population has used plants to treat symptoms of COVID-19 as reported in earlier work [ 5 ].…”

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Chebaibi

Bousta

Bourhia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

During the COVID-19 pandemic, the Moroccan population, like the entire population of the world, used medicinal plants to treat or cure symptoms of SARS-CoV-2. The present work was designed to identify the medicinal plants used by the Moroccan population in the prevention or treatment of COVID-19. To achieve this goal, a survey was conducted to collect data on plants along with the sociodemographic parameters of users. The outcome of this work showed that 1,263 people were interviewed with 63.5% male, aged between 18 and 82 years. Most plant users were between 20 and 40 years, which constituted 80.1% of the study population. The level of education of participants was 70.9% university and 27.6% secondary. The most useful plants were eucalyptus, cloves, lemon, and garlic. Notably, 61.9% of interviewed people used plants for preventing or treating COVID-19: 30.6% of them declared one-time use from the beginning of the pandemic, and 47.8% declared frequent daily use until recovery, while 17.4% declared single daily use. Five out of twenty-one plants used in the treatment are known for their potential toxicity, including Artemisia herba-alba and oleander ( Nerium oleander ). The findings of the present work could serve society by providing potential medicinal plants to control COVID-19.

show abstract

Section: Resultsmentioning

confidence: 99%

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Chebaibi

Bousta

Bourhia

et al. 2022

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…Kidneys, liver, and spleen were excised and weighed to calculate the relative weight. Organs excised were saved in 10% formalin for further histological analysis [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

“…The pharmacological activities of some compounds identified in the extract like ferrocene and its derivatives exhibiting anti-proliferative effects against lymphocytic leukaemia [15]. Ferrocene was considered to be a promising anti-malarial drug [16,17]. Phenazine derivatives have antimicrobial effects [18].…”

Section: Identification Of Phytochemical Compounds By Gc/msmentioning

confidence: 99%

Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract of Withania frutescens

et al. 2020

Self Cite

View full text Add to dashboard Cite

Withania frutescens (W. frutescens) is a medicinal plant widely used to treat several diseases. This work aims to study phytochemical composition as well as acute and subacute toxicity of W. frutescens hydroethanolic extract in mice. The phytochemical composition of W. frutescens extract was performed using gas chromatographic analysis. Acute toxicity was studied in vivo with oral administration of single doses 400 mg/kg, 1000 mg/kg, and 2000 mg/kg for 14 days. Subacute toxicity was studied with the administration of repeated doses of 400 mg/kg/day and 2000 mg/kg/day for 28 days. Phytochemical analysis of W. frutescens hydro-ethanolic extract confirmed the presence of interesting chemical compounds. Acute toxicity results showed no toxic symptoms in mice treated with an increasing dose up to a maximum of 2000 mg/kg. Alongside acute toxicity, subacute data showed no clinical symptoms nor biochemical or histological alteration in mice treated with an increasing dose up to a maximum of 2000 mg/kg compared to the control group (p < 0.05). This study shows no toxic effects in animals treated with W. frutescens extract, and, therefore, this plant can be considered safe in animals up to 2000 mg/kg under both acute and subacute toxicity conditions.

show abstract

“…Afterward, organs were excised and weighed in order to calculate the relative weight of organs. Vital organs such as kidney and liver were preserved in 10% formalin for histopathological analysis [ 24 ].…”

Section: Methodsmentioning

confidence: 99%

Withania frutescens. L Extract: Phytochemical Characterization and Acute and Repeated Dose 28-Day Oral Toxicity Studies in Mice

Moussaoui

Bourhia

Jawhari

et al. 2020

BioMed Research International

Self Cite

View full text Add to dashboard Cite

Background. Withania frutescens. L (W. frutescens) is a perennial woody medicinal plant belonging to family Solanaceae largely used by the indigenous population to Morocco for the treatment of disease. Objective. The purpose of this study was to investigate the chemical composition, acute, and subacute toxicity of W. frutescens extract in mice. Materials and Methods. The phytochemical composition of W. frutescens extract was determined using a gas chromatograph (GC/MS). Acute toxicity study was carried out in mice through oral administration of single doses 500 mg/kg, 1000 mg/kg, and 2000 mg/kg for 14 days. Subacute toxicity was performed with oral administration of repeated doses 500 and 2000 mg/kg/day for 28 days. Biochemical parameters (alanine aminotransferase, aspartate aminotransferase, urea, and creatinine), as well as histopathological changes potentially occurred in organs, (liver, kidney, and spleen) were evaluated. Results. The results of chromatographic analysis showed the richness of W. frutescens extract in interesting phytochemical compounds majorly constituted of bicyclo[3.1.1]heptane, 6,6-dimethyl-2-methylene-(C10H16). Regarding acute toxicity study, the results showed no clinical symptoms occurred in treated mice compared to the control group and no histological changes detected in analyzed organs of treated mice with dose put to 2000 mg/kg nor adverse effect on biochemical parameters. Conclusion. The outcome of this work showed no toxic effect of W. frutescens in mice up to dose 2000 mg/kg bodyweight. Therefore, this study could scientifically validate further traditional use with safety in the range of tested doses.

show abstract

Acute toxicity of plants mixture used in traditional treatment of edema and colic renal in Morocco

Cited by 13 publications

References 17 publications

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Ethnobotanical Study of Medicinal Plants Used against COVID-19

Phytochemical Identification, Acute, and Sub-Acute Oral Toxicity Studies of the Foliar Extract of Withania frutescens

Withania frutescens. L Extract: Phytochemical Characterization and Acute and Repeated Dose 28-Day Oral Toxicity Studies in Mice

Contact Info

Product

Resources

About