Acute toxicity of organophosphate fenitrothion on biomarkers in prawn Palaemonetes argentinus (Crustacea: Palaemonidae)

Lavarías, Sabrina María Luisa; Garcı́a, Carlos

doi:10.1007/s10661-014-4224-5

Cited by 20 publications

(5 citation statements)

References 61 publications

(81 reference statements)

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“…The reduced antioxidant levels in exposed crayfish were related to detoxification of oxidative stress, suggesting that the tested substances affect antioxidant defence systems. A similar trend to reduced antioxidant biomarker levels not accompanied by LPO has been reported in decapods after pesticide exposure 33,36,37,[57][58][59][60] . These effects have also been confirmed in fish after triazine exposure 54 .…”

Section: Discussionsupporting

confidence: 80%

Effects of metazachlor and its major metabolite metazachlor OA on early life stages of marbled crayfish

Velíšek

Stará

Kubec

et al. 2020

Sci Rep

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The effects of the herbicide metazachlor and its major metabolite metazachlor OA at two concentrations, including environmentally relevant concentrations of metazachlor (0.0115 µmol/l and 0.0790 µmol/l) and metazachlor OA (0.0117 µmol/l and 0.0805 µmol/l), respectively, were evaluated on early ontogeny, growth, behaviour, oxidative stress, antioxidant enzyme levels, histology, and mortality of marbled crayfish Procambarus virginalis. Both tested concentrations of metazachlor and metazachlor OA were associated with significantly lower growth and delayed ontogenetic development compared to controls. Exposure of metazachlor at 0.0115 µmol/l and metazachlor OA at 0.0117 µmol/l and 0.0805 µmol/l resulted in significantly lower activity of total superoxide dismutase (SOD), catalase (CAT), glutathione s-transferase (GST), glutathione reductase (GR), and reduced glutathione (GSH) compared with control and resulted in gill anomalies ranging from wall thinning to focal disintegration of branchial structure. Metazachlor at the environmentally relevant concentration of 0.0790 µmol/l was associated with significant alterations of crayfish distance moved and walking speed. The potential risk associated with metazachlor use in agriculture related to effects on non-target aquatic organisms.

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Section: Discussionsupporting

confidence: 80%

Effects of metazachlor and its major metabolite metazachlor OA on early life stages of marbled crayfish

Velíšek

Stará

Kubec

et al. 2020

Sci Rep

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“…The first line of defence is catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR), with the nonenzymatic antioxidants such as glutathione and vitamin E among others (Büyükgüzel, 2009; Felton & Summers, 1995) constituting a backup. Accordingly, the activities of these enzymes have been widely described in insects, crustaceans, mites and spiders among other arthropods (Gabellone et al, 2022; Huang et al, 2020; Lavarías & Garcia, 2015).…”

Section: Introductionmentioning

confidence: 99%

First biochemical and behavioural analysis of the response of the scorpion Urophonius brachycentrus (Thorell: 1876) upon exposure to an organophosphate

Garcia,

Ojanguren,

Seoane

et al. 2024

Medical Vet Entomology

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Scorpionism is an increasing public health problem in the world. Although no specific methodology or product is currently available for the control of those arachnids, the use of insecticides could be an effective tool. Chlorpyrifos is one of the insecticides used, but to date, whether scorpions recognise surfaces with that insecticide and how it affects their physiology and/or biochemistry is unknown. In the present study, we observed that scorpions recognise surfaces with 0.51 and 8.59 μg/cm2 of chlorpyrifos and avoid those areas. The 0.51 μg/cm2 concentration produced a decrease in acetylcholinesterase and an increase in catalase, superoxide dismutase and glutathione S‐transferase, whereas the 8.59 μg/cm2 concentration evoked a decrease in acetylcholinesterase and an increase in catalase and glutathione S‐transferase. Using the comet assay, we observed that the insecticide at 0.17, 0.51 and 8.59 μg/cm2 caused DNA damage. Finally, we found that the insecticide does not generate significant variations in glutathione peroxidase, glutathione reductase, the amount of protein or lipid peroxidation. The present results offer a comprehensive understanding of how scorpions respond, both at the biochemical and behavioural levels, when exposed to insecticides.

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“…Fenitrothion [O,Odimethyl-O-(3-methyl-4-nitrophenyl) phosphorothioate] is an OPs that has several uses in agriculture [2]. This pesticide is mainly used to control the detrimental effect of insects on rice, cereals, fruits, vegetables, stored grains and cotton.…”

Section: Introductionmentioning

confidence: 99%

Endocrine Disruption, Cytotoxicity and Genotoxicity of an Organophosphorus Insecticide

Belaid¹,

Methneni²,

Nasri³

et al. 2021

Sustainability

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In the present study, a battery of biological tests undertaken in vitro and in vivo was used to evaluate the toxic potential of an organophosphorus insecticide, namely Fenitrothion. The cytotoxic effect of pesticide was evaluated with the MTT assay against two human cancer cell lines: Hep-2 and MDA-MB-231. Genotoxicity was also studied using the bacterial VITOTOX® assay. The estrogenic effect was tested using the recombinant yeasts (YES) assay. Likewise, bioluminescence assays using V. fischeri and D. magna immobilization were performed. The results showed that Fenitrothion exhibits a variable cytotoxic effect depending on the dose as well as the studied cell lines, and no genotoxicity was observed in the tested sample. However, an estrogenic effect was recorded when investigating Fenitrothion using the recombinant yeasts (YES) assay. Analogously, acute toxicity was observed for both organisms and at all tested concentrations of Fenitrothion. Overall, these results underline the crucial importance of in vitro and in vivo bioassays in monitoring toxicity of pesticides.

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Acute toxicity of organophosphate fenitrothion on biomarkers in prawn Palaemonetes argentinus (Crustacea: Palaemonidae)

Cited by 20 publications

References 61 publications

Effects of metazachlor and its major metabolite metazachlor OA on early life stages of marbled crayfish

Effects of metazachlor and its major metabolite metazachlor OA on early life stages of marbled crayfish

First biochemical and behavioural analysis of the response of the scorpion Urophonius brachycentrus (Thorell: 1876) upon exposure to an organophosphate

Endocrine Disruption, Cytotoxicity and Genotoxicity of an Organophosphorus Insecticide

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