Acute Toxicity of a Homologous Series of Branched-Chain Primary Alcohols

Proposed Occupational Exposure Limits for Non-Carcinogenic Hanford Waste Tank Vapor Chemicals

“…An acute oral LD 50 for isooctyl alcohol in rats of 1.5 g/kg of body weight has been reported, and the principal signs of effect were central nervous system depression and labored respiration. In addition, mice, rats, and guinea pigs that inhaled 200 ppm isooctyl alcohol for 6 hours showed only moderate local irritation of the upper respiratory tract, but no signs of systemic intoxication were observed (Scala and Burtis 1973). These toxicological responses seen with isooctyl alcohol following either oral or inhalation exposure are reasonably comparable to the response seen with 2-ethyl-1-hexanol.…”

“…In mice, rats, and guinea pigs, the LC 50 for 2-ethyl-1-hexanol was >227 ppm (6-8 hour exposure) (Scala and Burtis 1973;Smyth et al 1969;Treon 1963). The oral LD 50 in rats reported in several studies was ~3 g/kg of body weight (Scala and Burtis 1973;Albro 1975;Treon 1963;NIOSH 1976). In these studies, the animals were observed for 24 hours prior to necropsy, and no deaths occurred during exposure or observation.…”

1‐Hexanol [MAK Value Documentation, 1998]

“…After instillation of a commercial product (44 % 1-hexanol, 53 % methyl-1-pentanol, 3 % 2-ethyl-1-butanol) into the eyes of 6 rabbits, severe irritation (iritis, clouding of the cornea and occasional corneal vascularization) was observed (Scala and Burtis 1973).…”

“…Dermal application of a commercial product (44 % 1-hexanol, 53 % methyl-1-pentanol, 3 % 2-ethyl-1-butanol) caused irritation of the skin of 4 albino rabbits and also symptoms of cerebral toxicity (ataxia, limb sprawling, respiratory depression) (Scala and Burtis 1973).…”

“…Moderate reversible mucosal irritation and slight pulmonary congestion were produced in mice (Swiss), rats (Sprague-Dawley) and guinea pigs (English Short Hair) by a 6-hour exposure to a commercial product containing 1-hexanol (44 % 1-hexanol, 53 % methyl-1-pentanol, 3 % 2-ethyl-1-butanol) (Scala and Burtis 1973).…”