Acute toxicity assessment of polyaniline/Ag nanoparticles/graphene oxide quantum dots on Cypridopsis vidua and Artemia salina

Abstract

Nanotoxicology is argued and considered one of the emerging topics. In this study, polyaniline (PANI)/2-acrylamido-2-methylpropanesulfonic acid (AMPSA) capped silver nanoparticles (NPs)/graphene oxide (GO) quantum dots (QDs) nanocomposite (PANI/Ag (AMPSA)/GO QDs NC) as a nanoadsorbent has a potential for removal of toxic hexavalent chromium (Cr(VI)) ions from water. The acute toxicity of this NC was evaluated on Artemia salina and freshwater Ostracods (Cypridopsis vidua) larvae for 48 h. The measurements were made at 24 and 48 h with 3 repetitions. The 50% effective concentration (EC50) values of the NC were determined after the exposure of these organisms. According to the results of the optical microscope, it was found that both experimental organisms intake the NC. In the toxicity results of Ostracods, the NC had a highly toxic effect only at 250 mg/L after 48 h and the EC50 value was 157.6 ± 6.4 mg/L. For Artemia salina individuals, it was noted that they were less sensitive than the Ostracods and EC50 value was 476 ± 25.1 mg/L after 48 h. These results indicated that PANI/Ag (AMPSA)/GO QDs NC has low toxicity towards both investigated organisms.

Novel antibacterial hydrogels based on gelatin/polyvinyl-alcohol and graphene oxide/silver nanoconjugates: formulation, characterization, and preliminary biocompatibility evaluation

“…One of the most attractive and widely studied nanostructured materials with antimicrobial activity on its own is silver nanoparticles (Ag NPs), which also offer high chemical stability, high surface-to-volume ratio, relatively low synthesis cost, ease of preparation, and high reactivity [ 26 , 27 ]. Ag NPs’ antibacterial activity has been attributed to their attachment to bacterial membranes, inducing disruption, leakage of bacterial inner components, and even inhibition of protein synthesis [ 13 ].…”

New Apoptosis Inducers Containing Anti-inflammatory Drugs and Pnictogen Derivatives: A New Strategy in the Development of Mitochondrial Targeting Chemotherapeutics

“…Artemia salina , a zooplanktonic crustacean, is used as a model organism for acute toxicity testing by the United States Environmental Protection Agency (US-EPA) . The assay is correlated with the toxicity data of rodents and humans and is generally used in testing acute toxicity of toxic materials, bioactive molecules, or metallodrugs …”

Nanobiology Dependent Therapeutic Convergence between Biocompatibility and Bioeffectiveness of Graphene Oxide Quantum Dot Scaffold for Immuno‐Inductive Angiogenesis and Nerve Regeneration

“…Consistent with our in vitro experiments and previous publications, GOQDs possess high biocompatibility, paving the way for potential application in PNI treatment. [ 34 ]…”