A lthough primary carcinomas of the tongue accounts for nearly 50% of oral carcinomas, tongue metastasis with acute swelling of the tongue as the initial manifestation of a lung cancer is extremely rare (1, 2). The differential diagnosis of acute tongue swelling includes hemorrhage, infarction, abscess, tumor, and edema (3). Several imaging techniques, including ultrasonography, computed tomography (CT), and magnetic resonance imaging (MRI), can be used to evaluate tongue swellings (4,5). CT is a useful tool for oral lesions, but MRI is superior in revealing the oral anatomy with excellent soft tissue detail and multiplanar capability (5); however, it is difficult to differentiate tongue abscess from malignancy on MRI because of the non-specific low signal intensity of the lesions on T1-weighted (W) images, and high signal intensity on T2W MR images (6).Herein we report the case of a lingual metastasis from lung cancer that presented with acute tongue swelling and respiratory distress, and mimicked abscess on CT and MRI.
Case reportA 58-year-old woman was referred to the emergency department with swelling and pain of the tongue, and difficulty in breathing. Her symptoms were present for three months prior to presentation, but there was a recent sharp increase in swelling and difficulty in breathing. On physical examination, it was difficult to open her mouth; the right side of the tongue was diffusely swollen and indurated. The overlying mucosa was intact and of normal color.A CT examination was performed, and a hypodense lesion was seen on the right anterior tongue (Fig. 1). For further characterization of the lesion, nonenhanced and contrast-enhanced MRI examination was done. The lesion was hypointense on T1W precontrast images, and hyperintense on T2W images (Fig. 2a). There was an incomplete irregular, thick, hypointense rim on T2W images (Fig. 2b). This rim was not seen on T1W images. After contrast administration, the lesion showed marked peripheral contrast enhancement, but the central part did not enhance (Fig. 2c).With these clinical and radiological findings, the lesion appeared to be an abscess. An attempt was made to drain the lesion, but it was unsuccessful. Therefore, the material obtained from this procedure was sent for cytological evaluation. Cytopathological examination revealed clusters of atypical cells showing cytoplasmic vacuolization and forming adenoid structures suggestive of metastatic adenocarcinoma.A chest CT examination was performed to locate the primary source of this lesion. On CT, there was a 3.5 x 2.5 cm right hilar mass (Fig. 3), and small metastatic nodules in the lung parenchyma. Cytological examination of the specimen obtained by bronchial brushing performed during endoscopy revealed adenocarcinoma. Based on these findings, ABSTRACT Primary tumors metastasizing to the oral cavity are extremely rare. Lung is one of the most common primary sources of metastases to the tongue. Although the incidence of lung cancer is increasing, tongue metastasis as the initial presentation of ...