Acute symptomatic seizures in critically ill children: frequency, etiology and outcomes

Rajper, Sanam Bano; Moazzam, Mujtaba; Zeeshan, Arsheen; Abbas, Qalab

doi:10.4103/jpn.jpn_140_19

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…'10 Meanwhile, acute symptomatic etiology with impaired consciousness right at the outset is frequently related to CSE with high morbidity and costs that increase with disease refractoriness, warranting detailed, exhaustive workup. 11 Literature suggests that CSE is significantly linked to morbidity. However, there is a lack of sufficient data to determine whether the severe outcomes are solely due to CSE or are influenced by factors such as the patient's age, management guidelines, and timing of arrival at healthcare settings.…”

Section: Introductionmentioning

confidence: 99%

Aetiology and Outcome of Childhood Convulsive Status Epilepticus

Wasim,

Al Maawali,

AlJabri

et al. 2024

Sultan Qaboos Univ Med J

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Objective: This study aimed to evaluate the etiology, management, and outcomes of convulsive status epilepticus (CSE) in children highlighting the factors that affect patient outcome. Methods: In a retrospective study spanning 2020 to 2023, 93 children with convulsive status epilepticus (CSE) treated at Sultan Qaboos University Hospital's emergency department (ED), High Dependency (HD), and intensive care unit (ICU) were analyzed. The Modified Rankin Scale at discharge determined CSE outcome. Results: Study of 93 children (mean age 4.84 years ± 3.64), predominantly Omani (92.47%). Acute 14 symptomatic (37.7%) and febrile tatus (31.2%) were primary causes. Diazepam used in 67.44% 15 cases as first-line treatment, with median seizure duration of 45 minutes. Successful control achieved in 16 76.34% within 60 minutes. Return to baseline in 55.9%, 5.38% mortality, and 38.7% disability. Etiology and 17 duration significantly impacted outcomes (p < 0.05). Conclusion: Acute symptomatic is the most common etiology of CSE, and a longer duration is associated with higher mortality and neurological disability. Therefore, managing CSE promptly and appropriately is crucial. Furthermore, identifying and treating the underlying cause is essential to reduce the duration of CSE and improve the outcome. Keywords: Etiology, Outcome, Convulsive Status Epilepticus, Modified Rankin Scale

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Section: Introductionmentioning

confidence: 99%

Aetiology and Outcome of Childhood Convulsive Status Epilepticus

Wasim,

Al Maawali,

AlJabri

et al. 2024

Sultan Qaboos Univ Med J

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“…World Health Organization (WHO) includes a reduced level of consciousness as one of the danger signs of severe pneumonia aiming for early diagnosis and hospitalization of sick children so that pneumonia-related deaths can be reduced [ 6 , 7 ]. A study from a pediatric intensive care unit mentioned that those who had a new-onset seizure, among them 17% had complicated pneumonia [ 8 ]. Many of the children under five years of age also presented with unconsciousness during admission.…”

Section: Introductionmentioning

confidence: 99%

Burden, predictors, and outcome of unconsciousness among under-five children hospitalized for community-acquired pneumonia: A retrospective study from a developing country

et al. 2023

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Despite the reduction of death from pneumonia over recent years, pneumonia has still been the leading infectious cause of death in under-five children for the last several decades. Unconsciousness is a critical condition in any child resulting from any illness. Once it occurs during a pneumonia episode, the outcome is perceived to be fatal. However, data on children under five with pneumonia having unconsciousness are scarce. We’ve retrospectively analyzed the data of under-five children admitted at the in-patient ward of Dhaka Hospital of icddr,b during 1 January 2014 and 31 December 2017 with World Health Organization classified pneumonia or severe pneumonia. Children presented with or without unconsciousness were considered as cases and controls respectively. Among a total of 3,876 children fulfilling the inclusion criteria, 325 and 3,551 were the cases and the controls respectively. A multivariable logistic regression analysis revealed older children (8 months vs. 7.9 months) (adjusted odds ratio, aOR 1.02, 95% CI: 1.004–1.04, p = 0.015), hypoxemia (aOR 3.22, 95% CI: 2.39–4.34, p<0.001), severe sepsis (aOR 4.46, 95% CI: 3.28–6.06, p<0.001), convulsion (aOR 8.90, 95% CI: 6.72–11.79, p<0.001), and dehydration (aOR 2.08, 95% CI: 1.56–2.76, p<0.001) were found to be independently associated with the cases. The cases more often had a fatal outcome than the controls (23% vs. 3%, OR 9.56, 95% CI: 6.95–13.19, p<0.001). If the simple predicting factors of unconsciousness in children under five hospitalized for pneumonia with different severity can be initially identified and adequately treated with prompt response, pneumonia-related deaths can be reduced more effectively, especially in resource-limited settings.

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Acute symptomatic seizures in critically ill children: frequency, etiology and outcomes

Cited by 2 publications

References 5 publications

Aetiology and Outcome of Childhood Convulsive Status Epilepticus

Aetiology and Outcome of Childhood Convulsive Status Epilepticus

Burden, predictors, and outcome of unconsciousness among under-five children hospitalized for community-acquired pneumonia: A retrospective study from a developing country

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