Acute Symptomatic Seizures

Beleza, Pedro

doi:10.1097/nrl.0b013e318251e6c3

Cited by 54 publications

(23 citation statements)

References 157 publications

(167 reference statements)

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“…Status epilepticus was defined as one continuous and unremitting seizure lasting for more than 5 min or recurrent seizures without restoration of consciousness for greater than 5 min [29]. Criteria for early and late PSSi were within 7 days or later from stroke onset [20, 30]. No distinction was made between acute symptomatic seizures and early PSSi.…”

Section: Methodsmentioning

confidence: 99%

“…AED treatment has been generally recommended for PSSi patients after the second seizure event, but not for the first PSSi, except when status epilepticus occurs as seizure onset [20]. This recommendation is based on the investigated virtue that AEDs might reduce the occurrence of second seizure, although AEDs have no effect on the pathogenesis of disease or its late prognosis [21, 22].…”

Section: Introductionmentioning

confidence: 99%

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Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure

et al. 2016

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BackgroundThe number of patients suffering post-stroke seizure after ischemic stroke (PSSi) is quite considerable, especially because ischemic stroke is more prevalent than hemorrhage in the general population. This study aimed to determine the predicting factors for seizure recurrence in ischemic stroke survivors and develop a clinical scoring system for the prediction of risks for seizure recurrence after the first PSSi.MethodsWe reviewed 3792 ischemic stroke patients from the Ewha Stroke Registry. A total of 124 (3.3 %) patients who experienced PSSi were recruited (mean follow-up for 44.4 months). Medical records concerning the etiology, functional disability, seizure onset latency from stroke, type of seizure, electroencephalography (EEG), and neuroimaging findings were statistically analyzed to derive a seizure recurrence risk scoring system.ResultsSeizures recurred in 35.4 % (17/48) of early PSSi patients (≤1 week since stroke onset) and 48.7 % (37/76) of late PSSi (>1 week) patients. Atrial fibrillation, large sized, and cortical stroke lesion were more common in late onset PSSi compared to those in early onset PSSi (p < 0.05). Seizure recurrence tended to be more prevalent in early PSSi patients with male gender, atrial fibrillation or cortical stroke lesion, severe functional disability, and partial seizures. Seizure recurrence in late PSSi group was more common in patients of young age (≤65 years old), male gender, large lesion size, and partial seizure type. The validity of seizure recurrence risk score in the early PSSi group was better when evaluating based on gender, atrial fibrillation, cortical lesion, functional disability, and partial seizure type, with sensitivity of 70.6 % and specificity of 71.0 %.ConclusionsOur study characterized the high risk group for seizure recurrence in patients with the first PSSi. PSSi patients with high risk score of seizure recurrence had a greater chance of developing epilepsy later. Therefore, they should be considered for further treatment such as antiepileptic drug medication in clinical practice.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure

et al. 2016

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“…We capitalized on aspects that are shared between our approach and medical conditions such as brain trauma, which often present with acute seizures without the process of epileptogenesis (Beleza, 2012). Our results also carry potential implications for chronic epilepsies with focal onset seizures.…”

Section: Discussionmentioning

confidence: 99%

Reliable and Elastic Propagation of Cortical Seizures In Vivo

et al. 2017

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Mapping the fine-scale neural activity that underlies epilepsy is key to identify potential control targets of this frequently intractable disease. Yet, the detailed in vivo dynamics of seizure progression in cortical microcircuits remain poorly understood. We combine fast two-photon calcium imaging (30-Hz) with LFP recordings to map, cell by cell, the spread of locally induced (4-AP or picrotoxin) seizures in anesthetized and awake mice. Using single-layer and microprism-assisted multi-layer imaging in different cortical areas we uncover reliable recruitment of local neural populations within and across cortical layers, and find layer-specific temporal delays, suggesting an initial supra-granular invasion followed by deep-layer recruitment during lateral seizure spread. Intriguingly, despite consistent progression pathways, successive seizures show pronounced temporal variability that critically depends on GABAergic inhibition. We propose an epilepsy circuit model resembling an elastic meshwork wherein ictal progression faithfully follows preexistent pathways but varies flexibly in time, depending on the local inhibitory restraint.

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“…Patients with histories of status epilepticus have a higher risk of recurrent unprovoked seizures, and the risk is much higher in patients with acute structural brain lesions than in patients with metabolic disturnbances 17,18. We usually administer antiepileptic drugs during the acute period of status epilepticus.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Seizures Following Focal Motor Status Epilepticus in a Patient with Non-Ketotic Hyperglycemia and Acute Cerebral Infarction

Lee¹,

Jung²,

Kang³

et al. 2014

J Epilepsy Res

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Focal motor status epilepticus (FMSE) is often associated non-ketotic hyperglycemia (NKH). There are no previous reports describing FMSE with NKH that was accompanied by an acute cerebral infarction and its long term follow-up result. We describe the case of a patient having focal motor status epilepticus (FMSE) associated with non-ketotic hyperglycemia (NKH) and acute cerebral infarction who later developed recurrent unprovoked seizures. A small acute infarct was observed in the left frontal subcortical area on diffusion-weighted images (DWI). FMSE was initially controlled with short term antiepileptic drugs and strict glucose control. Two years later, recurrent seizures occurred, and long-term antiepileptic drug treatment was administered. DWI should be considered for acute cerebral infarction in patients having FMSE associated with NKH, and careful follow-up should be conducted for such patients.

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Acute Symptomatic Seizures

Cited by 54 publications

References 157 publications

Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure

Clinical predictors of seizure recurrence after the first post-ischemic stroke seizure

Reliable and Elastic Propagation of Cortical Seizures In Vivo

Recurrent Seizures Following Focal Motor Status Epilepticus in a Patient with Non-Ketotic Hyperglycemia and Acute Cerebral Infarction

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