Introduction. Coronavirus disease 2019 is an infectious disease that
primarily affects the lungs. Since the pandemic of severe acute respiratory
syndrome coronavirus 2 continues and a large number of cases are registered
worldwide, the knowledge about the virus and virus-related complications is
growing as well. Pleural complications, pneumothorax, and empyema are
important issues affecting better patient survival. Bacterial
superinfections may cause complications of coronavirus disease 2019.
Knowledge about the incidence of superinfections, microbiological causes,
treatment, and outcomes of the disease is incomplete. Case Report. We
present two oxygen-dependent patients with coronavirus disease 2019 who
developed pneumothorax and empyema during hospitalization, three weeks after
the onset of coronavirus disease 2019 symptoms. Multidrug-resistant
Acinetobacter spp. was isolated from the thoracic drain. Conclusion.
Pneumothorax may occur at any stage of coronavirus disease 2019 and is not
always associated with the severity of viral infection. Empyema due to
coronavirus disease 2019 pneumonia is rare and occurs as a superinfection of
the pleural effusion. Excessive use of antibiotics in the treatment of
hospitalized patients with coronavirus disease 2019 may increase the risk of
nosocomial infections caused by multidrug-resistant bacteria.