Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms

Dikmen, Miriş; Özbabalık, Demet; Güneş, Hasan Veysi; Degirmenci, I.; Bal, Cengiz; Özdemir, Gazi; Başaran, Ayşe

doi:10.1111/j.1600-0404.2005.00556.x

Cited by 47 publications

(37 citation statements)

References 42 publications

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“…The ischaemic stroke subtypes of subjects with the ACE I/D polymorphism were investigated in 11 papers [6,7,8,9,10,11,12,13,14,15,16], in SVD (cases 1,020, controls 2,661) and LVD (cases 1,233, controls 2,370). ACE/DD OR 1.31 for small vessel stroke (95% CI 0.96–1.79, p = 0.09) compared to LVD (OR 1.02, 95% CI 0.82–1.26, p = 0.88) showed a preferential association for the DD genotype with SVD compared to LVD (fig.…”

Section: Resultsmentioning

confidence: 99%

Ischaemic Stroke Subtypes and Their Genetic Basis: A Comprehensive Meta-Analysis of Small and Large Vessel Stroke

et al. 2008

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Background: The extent to which genetic effects on the different subtypes of small (SVD) and large vessel disease (LVD) ischaemic stroke differ remains controversial. Methods: A comprehensive genetic meta-analysis of all genes investigated by ischaemic stroke subtype was conducted. Odds ratio (OR) and 95% confidence intervals (CI) were determined for each gene disease association. Results: From the initial search of 526 manuscripts, 5 candidate genes were studied comprising 7,533 cases (LVD 4,181, SVD 3,352) and 9,835 control subjects. There was a preferential association for SVD compared to LVD with ACE/DD (SVD: OR 1.31, 95% CI 0.96–1.79; LVD: OR 1.02, 95% CI 0.82–1.26) and eNOS intron 4 ab polymorphism (SVD: OR 1.41, 95% CI 0.94–2.11; LVD: OR 1.07, 95% CI 0.77–1.49), although statistical significance was not reached. No such preference was observed for MTHFR C677T, ApoE/ε4 or PAI-1 4G/5G polymorphism. The overall number of studies and the number of subjects recruited per study in whom stroke subtype was classified were small when compared to previous published work without such phenotype classification. Conclusion: Our findings suggest that genetic effects may differ between small and large vessel subtypes, although the evidence base is small.

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Section: Resultsmentioning

confidence: 99%

Ischaemic Stroke Subtypes and Their Genetic Basis: A Comprehensive Meta-Analysis of Small and Large Vessel Stroke

et al. 2008

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“…In terms of stroke subtypes, the T allele of the MTHFR gene is significantly associated with atherothrombotic stroke and WML in Japanese elderly individuals [73,74] . However, some studies have produced controversial results [75] . Racialethnic differences in folate metabolism and localized dietary differences may account for the disparity.…”

Section: Hyperhomocysteinemiamentioning

confidence: 99%

Genetics of stroke

Guo

Liu

2010

Acta Pharmacol Sin

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Stroke is the second most common cause of death and the most common cause of disability in developed countries. Stroke is a multifactorial disease caused by a combination of environmental and genetic factors. Numerous epidemiologic studies have documented a significant genetic component in the occurrence of strokes. Genes encoding products involved in lipid metabolism, thrombosis, and inflammation are believed to be potential genetic factors for stroke. Although a large group of candidate genes have been studied, most of the epidemiological results are conflicting. Studies of stroke as a monogenic disease have made huge progress, and animal models serve as an indispensable tool to dissect the complex genetics of stroke. In the present review, we provide insight into the role of in vivo stroke models for the study of stroke genetics.

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“…However, the role of another common MTHFR polymorphism, 1298A>C in paediatric stroke, is still uncertain. Conflicting results of the studies on the relationship between the 1298A>C polymorphism and AIS, both in children and adults, can be found [12][13][14][15][16][17]. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the 677C>T polymorphism increased homocysteine levels as well as lowered plasma folate levels [18].…”

Section: Introductionmentioning

confidence: 99%

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

2018

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An elevated level of homocysteine is a risk factor for vascular diseases, brain atrophy and several other disorders. The 1298A>C polymorphism (rs1801131) leads to mildly decreased MTHFR activity. Previously, it was observed that the MTHFR 1298A>C polymorphism in combined analysis with the MTHFR 677C>T polymorphism increases homocysteine levels. However, conflicting results on its relation to ischaemic stroke in children can be found. We conducted a meta-analysis to analyse possible connections between the MTHFR 1298A>C polymorphism and ischaemic stroke in paediatric patients. We identified available data published before December 2016 using appropriate keywords and searching PubMed as well as the references cited in the found articles. Eight case-control studies were included in the meta-analysis (426 children with stroke and 778 controls). Statistical analyses were made using R and Comprehensive Meta-Analysis softwares to investigate the impact of polymorphism in four models: dominant, recessive, additive and allelic. No publication bias was observed in the meta-analysis. We demonstrated no relationship between the 1298A>C polymorphism and ischaemic stroke in children in the case of recessive, additive and allelic models. However, the results of the dominant model analysis should be treated with caution due to the sensitivity analysis results. After omitting one of the included study, we observed a significant association between the carriers of the MTHFR C allele (cases with AC + CC genotypes) and ischaemic stroke in children (OR 1.35 95% CI 1.02-1.79, p = 0.035 in a fixed effects model). In conclusion, the 1298A>C polymorphism in the MTHFR gene is not a risk factor for ischaemic stroke in paediatric patients.

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Acute stroke in relation to homocysteine and methylenetetrahydrofolate reductase gene polymorphisms

Cited by 47 publications

References 42 publications

Ischaemic Stroke Subtypes and Their Genetic Basis: A Comprehensive Meta-Analysis of Small and Large Vessel Stroke

Ischaemic Stroke Subtypes and Their Genetic Basis: A Comprehensive Meta-Analysis of Small and Large Vessel Stroke

Genetics of stroke

Is the 1298A>C polymorphism in the MTHFR gene a risk factor for arterial ischaemic stroke in children? The results of meta-analysis

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