Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers

Дружкова, Т. А.; Pochigaeva, Ksenia; Yakovlev, A. A.; Kazimirova, E. A.; Grishkina, M. N.; Chepelev, Aleksey; Guekht, Alla; Gulyaeva, N. V.

doi:10.1007/s11011-018-0367-3

Cited by 23 publications

(15 citation statements)

References 46 publications

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“…Clinical studies have reported that systemic inflammation plays an important role in the occurrence and development of depression [5], [6]. To determine whether chronic systemic inflammation plays a role in the pathogenesis of depression, we compared the serum levels of systemic inflammation biomarkers, i.e.…”

Section: Resultsmentioning

confidence: 99%

“…Although chronic low-grade systematic inflammation has been implicated in the progression of some subtypes of depression in adults [5], [6], its association with the first-episode adolescent depression is still largely unknown. In this study, we recruited a cohort of 184 adolescent patients with depression and the same number of healthy controls with similar ages to investigate the possible etiology of adolescent depression.…”

Section: Discussionmentioning

confidence: 99%

“…Previous findings have shown that at least some subtypes of depression are associated with chronic low-grade systemic inflammation in adults [5], [6]. The levels of serum inflammatory markers are increased in some adult MDD patients.…”

Section: Introductionmentioning

confidence: 92%

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Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

Tao

Xiao

2019

Genomics, Proteomics &Amp; Bioinformatics

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Major depressive disorder (MDD) is the most common nonfatal disease burden worldwide. Systemic chronic low-grade inflammation has been reported to be associated with MDD progression by affecting monoaminergic and glutamatergic neurotransmission. However, whether various proinflammatory cytokines are abnormally elevated before the first episode of depression is still largely unclear. Here, we evaluated 184 adolescent patients who were experiencing their first episode of depressive disorder, and the same number of healthy individuals was included as controls. We tested the serum levels of high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), IgE, 14 different types of food antigen-specific IgG, histamine , homocysteine, S100 calcium-binding protein B, and diamine oxidase. We were not able to find any significant differences in the serum levels of hs-CRP or TNF-α between the two groups. However, the histamine level of the patients (12.35 μM) was significantly higher than that of the controls (9.73 μM, P < 0.001, Mann–Whitney U test). Moreover, significantly higher serum food antigen-specific IgG positive rates were also found in the patient group. Furthermore, over 80% of patients exhibited prolonged food intolerance with elevated levels of serum histamine, leading to hyperpermeability of the blood–brain barrier , which has previously been implicated in the pathogenesis of MDD. Hence, prolonged high levels of serum histamine could be a risk factor for depressive disorders, and antihistamine release might represent a novel therapeutic strategy for depression treatment.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

Tao

Xiao

2019

Genomics, Proteomics &Amp; Bioinformatics

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“…CNTF can influence several types of peripheral and central neurons [ 84 , 85 ], reduce synaptic depression during repetitive stimulation [ 86 ] and protect neurons from hypoxic injury [ 87 ]. CNTF levels increased in major depressive disorder, and CNTF was seen as a factor related to mental disease [ 88 ]. In addition, CNTF influenced stress-induced cortical norepinephrine synthesis, ensuing neuronal excitation and behavioral stereotypes [ 89 ], which may build a bridge between trauma experience and PTSD.…”

Section: Discussionmentioning

confidence: 99%

The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake

Bin

et al. 2020

BMC Psychiatry

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Background Posttraumatic stress disorder (PTSD) is the most prevalent type of psychiatric disorder among children after an earthquake. This study investigated the role of trauma experiences, personality traits, and genotype in the maintenance of PTSD symptoms. Methods In a previous large-scale epidemiological investigation 1 year after the Wenchuan earthquake, 215 children with PTSD symptoms were selected at random with their blood samples collected. All of them were followed up, and their PTSD symptoms were assessed 3 years later. The adolescent version of the UCLA PTSD Reaction Index, the earthquake exposure scale, and the Junior Eysenck Personality Questionnaire were used to determine PTSD symptoms, trauma experiences, and personality traits, respectively. We sequenced candidate genes involved in the regulation of long-term potentiation via NMDA-type receptors to identify the related SNP variations. Results Being trapped for a longer period of time, feeling one’s own or a family member’s life to be in danger, losing a close family member or friend, extraversion, neuroticism, TrkB, G72 and CNTF were found to be associated with the maintenance of PTSD symptoms. Conclusions Experiences, personality traits, and genotype influenced the maintenance of PTSD in child survivors who were considered to be followed up without medicine. This result could help to identify potential targets for treatment and promote the rational allocation of medical resources.

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“…Nonetheless, some studies find no differences in neurotransmitters between MDD patients and healthy controls (for a review, see Beijers et al, 2019). Similarly, it is widely accepted that hormones play a role in MDD etiology (Druzhkova et al, 2019) but there is no clear-cut connection between a specific hormone secretion and MDD. For example, Asadikaram et al (2019) found differences between MDD patients and healthy controls in hormone levels of adrenocorticotropic hormone, testosterone, thyroid-stimulating hormone, free thyroxine index, and cortisol/dehydroepiandrosterone sulfate (DHEA-S), while others consider vasopressin and oxytocin to play a pivotal role in MDD etiology (for a review, see Iovino et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis

et al. 2020

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Major depressive disorder (MDD) is the most severe depression type and one of the leading causes of morbidity worldwide. Animal models are widely used to understand MDD etiology, pathogenesis, and treatment, but the efficacy of this research for patients has barely been systematically evaluated. Such evaluation is important given the resource consumption and ethical concerns incurred by animal use. We used the citation tracking facilities within Web of Science and Scopus to locate citations of original research papers on rats related to MDD published prior to 2013-to allow adequate time for citations-identified in PubMed and Scopus by relevant search terms. Resulting citations were thematically coded in eight categories, and descriptive statistics were calculated. 178 publications describing relevant rat studies were identified. They were cited 8,712 times. More than half (4,633) of their citations were by other animal studies. 794 (less than 10%) were by human medical papers. Citation analysis indicates that rat model research has contributed very little to the contemporary clinical understanding of MDD. This suggests a misuse of limited funding hence supporting a change in allocation of research and development funds targeting this disorder to maximise benefits for patients.

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Acute stress response to a cognitive task in patients with major depressive disorder: potential metabolic and proinflammatory biomarkers

Cited by 23 publications

References 46 publications

Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

Chronic Food Antigen-Specific IgG-Mediated Hypersensitivity Reaction as A Risk Factor for Adolescent Depressive Disorder

The role of trauma experiences, personality traits, and genotype in maintaining posttraumatic stress disorder symptoms among child survivors of the Wenchuan earthquake

The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis

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