Acute stress persistently alters instrumental motivation without affecting appetitive Pavlovian conditioning, extinction, or contextual renewal

Derman, Rifka C.; Lattal, K. Matthew

doi:10.1016/j.nlm.2023.107771

Cited by 3 publications

(1 citation statement)

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“…For example, studies from Shaham's group demonstrated that yohimbine, which produces a stress-like response in animals, induced reinstatement in food-seeking (Ghitza et al, 2005;Nair et al, 2010;Lê et al, 2011). However, intermittent footshock-induced stress promoted (Chen et al, 2014) or had no effect (Ahmed and Koob, 1997;Buczek et al, 1999) on reinstatement in food-seeking, whereas a recent study revealed that acute footshock-induced stress decreased appetitive learning and motivated behavior (Derman and Matthew Lattal, 2023). In human studies, after acute stress such as threat-ofshock or cold condition (Bogdan and Pizzagalli, 2006;Morris and Rottenberg, 2015;Burani et al, 2021), or in post-traumatic stress disorder (PTSD) patients (Hopper et al, 2008;Nawijn et al, 2015), these subjects displayed dysfunction of reward processing.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological activation of the amygdala, but not single prolonged footshock-induced acute stress, interferes with cue-induced motivation toward food rewards in rats

Lai,

Chang

2023

Front. Behav. Neurosci.

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In the face of threats, animals adapt their behaviors to cope with the situation. Under such circumstances, irrelevant behaviors are usually suppressed. In this study, we examined whether food-seeking motivation would decrease under activation of the amygdala, an important nucleus in the regulation of stress response in the central nervous system, or after a physical acute stress session. In Experiment 1, we pharmacologically activated the basolateral nucleus (BLA) or the central nucleus of the amygdala (CeA) before a cue-induced reinstatement test in rats. Our results showed that activation of the BLA or the CeA abolished cue-induced motivation toward food rewards, while locomotor activity and free food intake were not affected. In Experiments 2 and 3, we further assessed anxiety and despair levels, as well as cue-induced reinstatement, after a single prolonged footshock-induced acute stress in rats. Behaviorally, acute stress did not affect anxiety level, despair level, or cue-induced motivation toward food rewards. Physiologically, there was no difference in cellular activities of the amygdala immediately after acute stress. To conclude, our results suggested that pharmacological activation of the amygdala decreased cue-induced motivation toward food reward. However, physiological acute stress did not immediately interfere with the negative emotions, motivation, or amygdala activities of the animals.

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