Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making

Shafiei, Naghmeh; Gray, Mary C.; Viau, Victor; Floresco, Stan

doi:10.1038/npp.2012.69

Cited by 141 publications

(126 citation statements)

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“…As shown in Figure 4a, ICV infusion of 3 μg CRF did not significantly alter decision-making on this simpler task (F(1,8) = 0.86, n.s.). Interestingly, these treatments did significantly increase choice latencies (main effect of treatment: F(1,8) = 8.76, po0.05; treatment × block interaction: F(3,24) = 2.50, p = 0.08; Figure 4b) in a manner similar to the effects of restraint on performance of this task (Shafiei et al, 2012). However, trial omissions were unaffected (vehicle = 0; CRF = 1.4+/ − 0.8; t(8) = 1.77, n.s.).…”

Section: Central Crf Infusion Does Not Disrupt Reward Magnitude Discrmentioning

confidence: 55%

“…Previous work from our laboratory revealed that 1 h of restraint stress markedly reduced preference for larger rewards associated with a greater effort cost (Shafiei et al, 2012). It is well established that this form of acute stress increases circulating corticosterone levels and also enhances dopamine efflux in regions such as the prefrontal cortex and amygdala (Imperato et al, 1991;Jackson and Moghaddam, 2004;Del Arco et al, 2015).…”

Section: Stress Cost/benefit Decision-making and Crfmentioning

confidence: 81%

“…Studies in humans have shown that different forms of acute stress can lead to disadvantageous or more automatized patterns of decisionmaking when choosing between options associated with different magnitudes and probabilities of obtaining rewards (Starcke et al, 2008;Porcelli and Delgado 2009;Pabst et al, 2013). Similarly, studies by our group have shown that acute restraint stress in rats induces a reliable and pronounced reduction in preference for larger rewards associated with greater effort costs, as well as an increase in decision latencies (Shafiei et al, 2012). The observation is particularly interesting in light of the fact that patients diagnosed with depression also show reduced preference to work harder for larger rewards in a back-translated effort-based decisionmaking task (Treadway et al, 2012).…”

Section: Introductionmentioning

confidence: 81%

“…However, the effects of stress on effort-related decision-making did not appear to be driven by these factors. Pharmacological antagonism of dopamine receptors did not alter the effects of restraint stress on effort-related choice, and treatment with physiologically relevant doses of corticosterone did not recapitulate the effects of stress on this form of decisionmaking (Shafiei et al, 2012). This indicates that other neurochemical mechanisms activated by stress may mediate its effects on cost/benefit decision-making.…”

Section: Introductionmentioning

confidence: 88%

“…However, in attempting to elucidate the neurochemical mechanisms underlying this effect, we found that systemic treatment with corticosterone at doses yielding plasma levels comparable with those induced by stress failed to recapitulate this effect. Similarly, stress-induced perturbations on choice behavior did not appear to be driven by increased dopamine transmission, as pretreatment with the dopamine antagonist flupenthixol failed to block the effect of acute stress on this measure (Shafiei et al, 2012). We now reveal that CRF transmission has a fundamental role in mediating the stress-induced alterations in effort choice preference, as pretreating rats with the CRF antagonist, alpha-helical CRF, markedly attenuated the effect of restraint stress, while this drug had no effect on behavior on its own.…”

Section: Stress Cost/benefit Decision-making and Crfmentioning

confidence: 95%

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Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

Bryce

Floresco

2016

Neuropsychopharmacol

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Acute stress activates numerous systems in a coordinated effort to promote homeostasis, and can exert differential effects on mnemonic and cognitive functions depending on a myriad of factors. Stress can alter different forms of cost/benefit decision-making, yet the mechanisms that drive these effects remain unclear. In the present study, we probed how corticotropin-releasing factor (CRF) may contribute to stress-induced alterations in cost/benefit decision-making, using an task where well-trained rats chose between a low effort/ low reward lever (LR; two pellets) and a high effort/high reward lever (HR; four pellets), with the effort requirement increasing over a session (2, 5, 10, and 20 presses). One-hour restraint stress markedly reduced preference for the HR option, but this effect was attenuated by infusions of the CRF antagonist, alpha-helical CRF. Conversely, central CRF infusion mimicked the effect of stress on decision-making, as well as increased decision latencies and reduced response vigor. CRF infusions did not alter preference for larger vs smaller rewards, but did reduce responding for food delivered on a progressive ratio, suggesting that these treatments may amplify perceived effort costs that may be required to obtain rewards. CRF infusions into the ventral tegmental area recapitulated the effect of central CRF treatment and restraint on choice behavior, suggesting that these effects may be mediated by perturbations in dopamine transmission. These findings highlight the involvement of CRF in regulating effort-related decisions and suggest that increased CRF activity may contribute to motivational impairments and abnormal decision-making associated with stress-related psychiatric disorders such as depression.

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Section: Central Crf Infusion Does Not Disrupt Reward Magnitude Discrmentioning

confidence: 55%

Section: Stress Cost/benefit Decision-making and Crfmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 88%

Section: Stress Cost/benefit Decision-making and Crfmentioning

confidence: 95%

See 3 more Smart Citations

Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

Bryce

Floresco

2016

Neuropsychopharmacol

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Hippocampal neurogenesis promotes effortful responding but does not regulate effort‐based choice

et al. 2022

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A fundamental trait of depression is low motivation. Hippocampal neurogenesis has been associated with motivational deficits but detailed evidence on how it regulates human‐relevant behavioral traits is still missing. We used the hGFAP‐TK rat model to deplete actively dividing neural stem cells in the rat hippocampus. Use of the effort‐discounting operant task allowed us to identify specific and detailed deficits in motivation behavior. In this task, rats are given a choice between small and large food rewards, where 2–20 lever presses are required to obtain the large reward (four sugar pellets) versus one press to receive the smaller reward (two sugar pellets). We found that depleting adult neurogenesis did not affect effort‐based choice or general motivation to complete the task. However, lack of adult neurogenesis reduced the pressing rate and thus increased time to complete the required presses to obtain a reward. In summary, the present study finds that adult hippocampal neurogenesis specifically reduces response vigor to obtain rewards and thus deepens our understanding in how neurogenesis shapes depression.

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Effort and effort discounting as predictors of seeking psychotherapy among individuals with depression

Trusty

Swift

2023

J Clin Psychol

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ObjectivesMany individuals who experience depression do not seek psychotherapy, and past research has had limited success in predicting help‐seeking in this population. Accounting for behavioral characteristics of depression that affect help‐seeking decisions, such as effort discounting (devaluation of rewards as a function of effort), may address this gap.MethodsIndividuals with moderate‐severe depression symptoms who were not in psychotherapy (N = 253) reported their depression symptom severity and the amount of effort they anticipated seeking psychotherapy would require; they also completed a behavioral measure of effort discounting. At a 3‐month follow‐up, they reported whether they initiated psychotherapy during the follow‐up period.ResultsDepression symptom severity was associated with perceptions that seeking psychotherapy would be more effortful. In turn, perceptions that seeking psychotherapy would be more effortful prospectively predicted a lower likelihood of initiating psychotherapy. Effort discounting was unrelated to psychotherapy use.ConclusionsThese results suggest that differences in the anticipated effort required to seek psychotherapy can increase depressed individuals' risk of going untreated. Future research may test whether reducing the effort of seeking psychotherapy increases psychotherapy use among those with depression. For instance, streamlining insurance enrollment procedures, implementing patient decision aids, or offering telehealth treatment options may be beneficial.

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Acute Stress Induces Selective Alterations in Cost/Benefit Decision-Making

Cited by 141 publications

References 75 publications

Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

Perturbations in Effort-Related Decision-Making Driven by Acute Stress and Corticotropin-Releasing Factor

Hippocampal neurogenesis promotes effortful responding but does not regulate effort‐based choice

Effort and effort discounting as predictors of seeking psychotherapy among individuals with depression

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