“…Not only physical stress (15,16,20,22,23) but also psychological and psychosocial stress (2,3,6,(11)(12)(13)24) increase the concentrations of adrenalin, noradrenalin, and dopamine in peripheral blood plasma, resulting in the change of lymphocyte numbers in peripheral blood (3,4,6,10,13,14,16,17). As for clinical importance, acute stress activates immune system and improves wound healing, vaccination, or resistance to infection (5,7,8,24), while chronic stress is immunosuppressive (19) and impairs wound healing (9,21).…”