Acute sporadic hepatitis E virus infection in southern China

Tan, De; Im, Stanley W.K.; Yao, Ji Lu; Ng, Mun Hon

doi:10.1016/s0168-8278(95)80001-8

Cited by 15 publications

(5 citation statements)

References 32 publications

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“…However, studies on children show that they are susceptible to HEV infection and many cases of sporadic acute viral hepatitis are caused by HEV [5][6][7]. Results of studies on children from Sudan [8] and Hong Kong [9] have demonstrated that 59.0% and 11.7% of cases of acute sporadic hepatitis cared for in hospital had evidence of recently acquired HEV infection.…”

Section: Introductionmentioning

confidence: 99%

Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran

Farhadi²,

Ajami³

et al. 2009

East Mediterr Health J

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The seroprevalence of hepatitis E virus infection (HEV) in children and young adults was determined in a community-based survey in an area of northern Islamic Republic of Iran. Serum samples were taken from 1080 randomly selected apparently healthy 2-25-year-olds from urban and rural regions of Sari district. Anti-HEV IgG antibodies were detected in 25 individuals (2.3%). Seroprevalence increased significantly with age from 3/255 (1.2%) in children < 10 years to 8/110 (7.3%) in those aged 20-25 years. No differences in HEV status were noted between the sexes. Earlier age at exposure to infection and a higher infection rate were found in people residing in rural areas than in urban areas.Séroépidémiologie de l'infection par le virus de l'hépatite E chez les enfants et les jeunes de 2 à 25 ans dans le district de Sari (République islamique d'Iran) RÉSUMÉ La séroprévalence de l'infection par le virus de l'hépatite E (VHE) chez les enfants et les jeunes adultes a été déterminée grâce à une enquête communautaire réalisée dans une région du nord de la République islamique d'Iran. Des échantillons de sérum ont été prélevés sur 1 080 enfants et jeunes âgés de 2 à 25 ans sélectionnés au hasard, apparemment en bonne santé, qui venaient de régions urbaines et rurales du district de Sari. Des anticorps anti-VHE de type IgG ont été détectés chez 25 sujets (2,3 %). La séroprévalence augmentait significativement avec l'âge, de 3 sur 255 (1,2 %) chez les enfants de moins de 10 ans à 8 sur 110 (7,3 %) chez les jeunes âgés de 20 à 25 ans. Aucune différence n'a été observée entre les deux sexes quant à la sérologie VHE. L'enquête a montré que les personnes vivant en zone rurale étaient exposées plus jeunes à l'infection et connaissaient un taux d'infection plus élevé que celles vivant en zone urbaine.

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Section: Introductionmentioning

confidence: 99%

Seroepidemiology of hepatitis E virus infection in 2-25-year-olds in Sari district, Islamic Republic of Iran

Farhadi²,

Ajami³

et al. 2009

East Mediterr Health J

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“…Thereafter, outbreaks of HEV have been reported in other developing countries [Krawczynski, 1993] and sporadic cases of HEV have also been reported worldwide [Tan et al, 1995]. HEV is transmitted by the oralfaecal route.…”

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology of hepatitis E virus in Hong Kong

Tai¹,

Cheng²,

Ip³

et al. 2009

Journal of Medical Virology

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Hepatitis E virus (HEV) is one of the major causes of acute and self-limiting hepatitis in human. In Hong Kong, the number of notifications increased from 26 to 62 from year 2001 to 2007. This study describes the molecular epidemiology of HEV in Hong Kong in order to determine the movement and distribution of HEV. HEV in 171 serum samples from HEV IgM positive cases from year 2001 to 2007 were amplified using RT-PCR and subjected to nucleotide sequencing. Phylogenetic analysis showed 162 of 171 HEV detected cases (94.7%) belonged to genotype IV and 8 (4.7%) to genotype I. Interestingly, a cluster of 10 cases in year 2007 that had the same sequence of HEV was identified. Epidemiological data however did not detect any relationship between these cases. Since zoonotic transmission is a well known route of HEV infection, close monitoring of the circulating HEV strains in human and food source animals may help to provide additional information on the transmission of HEV and possible source of infection in Hong Kong.

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“…Acute hepatitis A (AHA) and acute hepatitis E (AHE) are both transmitted by a fecal–oral route 1–7 . Their clinical manifestations are similar 1–5 .…”

Section: Introductionmentioning

confidence: 99%

“…In the USA, the estimated incidence is nine cases per 100 000‐population 1 . Acute hepatitis E is more prevalent in developing countries in tropical and subtropical areas such as South‐East and central Asia, the Middle East, northern and western parts of Africa, and Mexico 1–7 . In developed countries, it is usually considered to be an ‘imported disease’, via traveling, visiting, trading, or immigration.…”

Section: Introductionmentioning

confidence: 99%

“…When they get acute hepatitis A by traveling to an endemic area, living in the day‐care center, being military pessonnel in crowded barracks or any other possible exposure, symptoms may be more severe. As for hepatitis E, hepatitis A accounts for sporadic and major epidelics of viral hepatitis in developing countries, but only sporadic cases in developed countries 1–7 . So epidemiology, clinical manifestations, and prognosis of these two enterically transmitted forms of viral hepatitis may be different in different countries.…”

Section: Introductionmentioning

confidence: 99%

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