Acute Skeletal Muscle Wasting in Critical Illness

Puthucheary, Zudin; Rawal, J; McPhail, Mark; Connolly, Bronwen; Ratnayake, Gamunu; Chan, Pearl; Hopkinson, Nicholas; Padhke, Rahul; Dew, Tracy; Sidhu, Paul S.; Velloso, Cristiana P.; Seymour, John; Agley, Chibeza C.; Selby, Anna; Limb, Marie C.; Edwards, Lindsay M.; Smith, Kenneth E.; Rowlerson, A; Rennie, Michael J.; Moxham, John; Harridge, Stephen D. R.; Hart, Nicholas; Montgomery, H. E.

doi:10.1097/01.sa.0000450914.29374.55

Cited by 218 publications

(398 citation statements)

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“…The development of CCU-acquired weakness alone is associated with long periods of ventilation (15,16), high severity of illness scores (17), multi-organ failure (18) and immobility (19). Reductions of up to 25% in muscle bulk occur in the first 10 days of admission (18) and cause longer term disability (20).…”

Section: Objectivesmentioning

confidence: 99%

See 1 more Smart Citation

An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis

Burke

Gorman

Stokes

et al. 2014

Clinical Respiratory J

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Objective: To review, in conformance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, the totality of evidence for the use of neuromuscular electrical stimulation (NMES) . Limits of the English language and human studies were applied. Study Selection: Trials investigating the effect of NMES in critical care adult patients were included. One reviewer excluded articles by title. Two reviewers excluded remaining articles by abstract and full text. One reviewer extracted data under a standardised form. Two reviewers assessed methodological quality using the Cochrane Risk of Bias Tool and the Newcastle Ottawa Scale. Results: Twelve full-text articles, eleven randomised controlled trials (RCTs) and one case-control trial indicated the potential of NMES to preserve muscle mass and joint range of motion, improve outcomes of ventilation, and reduce activity limitations. Meta-analysis from three RCTs supported NMES to preserve muscle strength using a fixed-effects model [n = 146; standardised mean difference 0.93 (0.51, 1.35) P = 0.0002]; however, significant heterogeneity was recorded. No outcomes evaluated the effect on participation restrictions. Conclusion: NMES, as an adjunct to current rehabilitation practices in critically ill patients, may maintain muscle strength. However, high-quality studies with longer follow-up periods and standardised outcome measures across all domains of the ICF framework are required. Authorship and contributorshipMs Dearbhla Burke designed and performed the electronic database search, screened the articles for inclusion, evaluated the quality of the included studies, collected the data, completed narrative analysis and statistical meta-analysis, and wrote the paper. Ms Emma Gorman designed the concept of the review, contributed to search strategy development, and acted as a third party to resolve disagreements regarding screening and quality assessment. Mr Diarmaid Stokes assisted in study design and the development of a search strategy, provided training and assistance with Endnote bibliography software, and retrieved full-text articles using inter-library loans. Dr Olive Lennon designed the study, screened articles for eligibility, completed quality assessment of papers, discussed statistical analysis and reviewed report writing. EthicsAs a systematic review of published data, this study required no ethical approval.

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Section: Objectivesmentioning

confidence: 99%

“…Patients with severe critical illness have higher incidence of rapidly acquired CCU weakness (17,18). Therefore, logic would suggest application of NMES in the acute stage.…”

Section: Not Addressedmentioning

confidence: 99%

An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis

Burke

Gorman

Stokes

et al. 2014

Clinical Respiratory J

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“…Skeletal muscle mass and function are important factors associated with outcomes in critically ill patients. [1][2][3][4][5][6][7][8][9] While muscular atrophy and weakness are well-recognized consequences of critical illness, 10,11 there is growing appreciation for the impact of premorbid health status and muscle function on the outcomes of critical illness. Baseline frailty is associated with a higher risk of death and long-term disability after critical illness, 12,13 possibly because of diminished physiological reserve and reduced axial skeletal muscle mass and strength (sarcopenia).…”

Section: Introductionmentioning

confidence: 99%

“…Baseline Tdi and Clinical Outcomes total of 28 patients requiring invasive mechanical ventilation following solid-organ transplantation were enrolled (19 with lung transplantation, 18 with liver transplantation, and 1 with cardiac transplantation). In this subgroup, lower baseline Tdi was associated with prolonged mechanical ventilation (median [IQR], 16[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] vs 5[3][4][5][6][7][8][9][10][11][12] days; P = .03) (Figure 1B). The differences in duration of ICU stay (median [IQR], 16[9][10][11][12][13][14][15][16][17][18][19][20][21][22] vs 7[4][5][6][7][8][9]…”

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confidence: 99%

Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults

et al. 2020

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IMPORTANCE Low diaphragm muscle mass at the outset of mechanical ventilation may predispose critically ill patients to poor clinical outcomes. OBJECTIVE To determine whether lower baseline diaphragm thickness (Tdi) is associated with delayed liberation from mechanical ventilation and complications of acute respiratory failure (reintubation, tracheostomy, prolonged ventilation >14 days, or death in the hospital).

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“…11,12 Sudden muscle atrophy is almost an unavoidable consequence in critically ill patients in intensive care units. [13][14][15][16][17] Objective assessment of muscle thickness at the bedside could be a useful marker for clinicians to assess relative contributions of muscle and fat and balance nutritional support to attenuate such muscle mass loss.…”

Section: Introductionmentioning

confidence: 99%

Ultrasound imaging for measuring muscle and subcutaneous fat tissue thickness of the anterior thigh: A two-year longitudinal study in middle age

Mechelli¹

2019

JCSM Clinical Reports

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Background Ultrasound (US) imaging technique is widely used in research and clinical settings to assess the morphology and morphometry of neuromusculoskeletal structures. The technique has reported validity and reliability in measuring the size of various muscles under controlled conditions. The aim of the present study was to assess anterior thigh thickness using US imaging, in a healthy cohort of middle‐aged older adults. Methods Participants included 17 healthy older adults involved in regular moderate‐vigorous activities (age range 39–66 years). US imaging scans of the anterior thighs 2 years since baseline measurements were performed. Images were analysed offline to compare US imaging measurements of muscle thickness and subcutaneous fat (SF) of the anterior thigh taken at baseline and after 2 years. Results There was no significant difference between muscle thickness measurements taken at baseline and after 2 years (mean, standard deviation; baseline = 2.80 ± 0.71 cm; follow‐up = 2.77 ± 0.72 cm, P = 0.33). There was also no significant change in SF thickness (baseline = 1.04 ± 0.41 cm; follow‐up = 1.06 ± 0.40, P = 0.33). Conclusions The results show that there was no decline in anterior thigh muscle thickness or increase in SF in the healthy cohort studied using US imaging over a 2 year period. These findings demonstrate the robustness of US imaging measurements over time.

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Acute Skeletal Muscle Wasting in Critical Illness

Cited by 218 publications

References 0 publications

An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis

An evaluation of neuromuscular electrical stimulation in critical care using the ICF framework: a systematic review and meta‐analysis

Association of Low Baseline Diaphragm Muscle Mass With Prolonged Mechanical Ventilation and Mortality Among Critically Ill Adults

Ultrasound imaging for measuring muscle and subcutaneous fat tissue thickness of the anterior thigh: A two-year longitudinal study in middle age

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