Acute severe ulcerative colitis: State of the art treatment

Gisbert, Javier P.; Chaparro, María

doi:10.1016/j.bpg.2018.05.007

Cited by 32 publications

(24 citation statements)

References 93 publications

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“…Ulcerative colitis (UC) is a refractory inflammatory disease of the large intestine [1], and the pathogenesis of UC is not fully understood. In addition to conventional treatment with corticosteroids and amino salicylic acid [2], the treatments of UC are including many new drugs such as TNF-antibody clinically widely used [3–6]. However, patients with ulcerative colitis often relapse after a certain period of treatment, which leads to serious economic and mental problems [7].…”

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Gao

Wang

et al. 2019

BioMed Research International

148

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Objective. Observe the protective effect of chlorogenic acid on dextran sulfate-induced ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway. Methods. Seventy C57BL/6 mice (half males and half females) were randomly divided into 7 groups, 10 in each group: control group (CON group), UC model group (UC group), and sulfasalazine-positive control group (SASP group), chlorogenic acid low dose group (CGA-L group), chlorogenic acid medium dose group (CGA-M group), chlorogenic acid high dose group (CGA-H group), and ERK inhibitor + chlorogenic acid group (E+CGA group). The effects of chlorogenic acid on UC were evaluated by colon mucosa damage index (CMDI), HE staining, immunohistochemistry, ELISA, and Western blot. The relationship between chlorogenic acid and MAPK/ERK/JNK signaling pathway was explored by adding ERK inhibitor. Results. The UC models were established successfully by drinking DSS water. Chlorogenic acid reduces DSS-induced colonic mucosal damage, inhibits DSS-induced inflammation, oxidative stress, and apoptosis in colon, and reduces ERK1/2, p -ERK, p38, p-p38, JNK, and p-JNK protein expression. ERK inhibitor U0126 reversed the protective effect of chlorogenic acid on colon tissue. Conclusion. Chlorogenic acid can alleviate DSS-induced ulcerative colitis in mice, which can significantly reduce tissue inflammation and apoptosis, and its mechanism is related to the MAPK/ERK/JNK signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Gao

Wang

et al. 2019

BioMed Research International

148

View full text Add to dashboard Cite

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“…7 Other indices like the clinical partial Mayo clinic score and the Montreal classification are less frequently used in clinical practise, however comparative studies for diagnosis of ASUC are not available. 3 , 8 …”

Section: Challenges Associated With Asuc Managementmentioning

confidence: 99%

“…This allows for early and multidisciplinary planning of medical and/or surgical rescue therapy. 3 , 8 Several predictive indices have been developed but are infrequently used in clinical practise.…”

Section: Challenges Associated With Asuc Managementmentioning

confidence: 99%

Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions

Holvoet

Lobatón²,

Hindryckx³

2021

CEG

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Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy rates remain high (approximately 30%) despite advances in therapy. Colectomy in ASUC is particularly associated with important postoperative complications and morbidity. In this review, reasons for the inability to improve care and avoid evolution to colectomy for ASUC are explored and solutions that might lead to a better management of the disease are investigated.

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“…Some of them are characterized by acute symptoms that can lead to serious manifestations such as digestive bleeding and emergency intervention. Other pathologies, however, have a prolonged course over time and tend to become chronic [ 1 , 2 ], that is, to become permanent, with a heavy impact on the quality of life. In Europe, pancreatic cancer is the sixth most prevalent cancer, accounting for 2.8% of the cancer cases among men and 3.2% among women.…”

Section: Introductionmentioning

confidence: 99%

Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma

Castiglione

Calogero

Vicari

et al. 2020

Case Reports in Gastrointestinal Medicine

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Pancreatic cancer is a most frequent cancer in Europe, and the majority of cases of cancer of the pancreas are diagnosed above the age of 65. Radical surgery is the first curative treatment of pancreatic cancer, and alternative or combined therapeutic options, in particular, consist of adjuvant or neoadjuvant chemotherapy, with or without radiotherapy. Many factors, including diet and genetics, have been implicated in the development of cancer of the pancreas. Poly (ADP-ribose) polymerase 1 (PARP-1) protein is required for translocation of the apoptosis-inducing factor (AIF) from the mitochondria to the nucleus. It is involved in programmed cell death processes. Different PARP-1 gene expression proteins have been observed in various tumors such as lung, ovarian, endometrial, skin, and glioblastoma. We evaluated the expression of PARP-1 protein in pancreatic adenocarcinoma and normal pancreas tissues by immunohistochemistry. Protein PARP-1 in the nucleus was found in all samples (normal pancreas and pancreatic adenocarcinoma tissues). No cytoplasmic staining was observed in any sample. PARP-1-positive cells resulted higher in the normal pancreas compared with the pancreas with adenocarcinoma. PARP-1 overexpression in prostate cancer tissue compared with normal prostate suggests a greater activity of PARP-1 in these tumors. These findings suggest that PARP-1 expression in prostate cancer is an attempt to trigger apoptosis in this type of tumor, similarl to that reported in other cancers. This finding suggests that PARP-1-mediated cell death pathways are inhibited in this cancer.

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Acute severe ulcerative colitis: State of the art treatment

Cited by 32 publications

References 93 publications

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions

Poly (ADP-Ribose) Polymerase 1 Protein Expression in Normal Pancreas and Pancreatic Adenocarcinoma

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