Acute severe paediatric asthma: study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study

Craig, Simon; Babl, Franz E; Dalziel, Stuart R; Gray, Charmaine; Powell, Colin; Ansari, Khalid Al; Lyttle, Mark D; Roland, Damian; Benito, Javier; Velasco, Roberto; Hoeffe, Julia; Moldovan, D; Thompson, Graham; Schuh, Suzanne; Zorc, Joseph J.; Kwok, Maria Y.; Mahajan, Prashant; Johnson, Michael D.; Sapién, Robert; Khanna, Kajal; Rino, Pedro; Prego, Javier; Yock, Adriana; Fernandes, Ricardo M; Santhanam, Indumathy; Cheema, Baljit; Ong, Gene Yong-Kwang; Chong, Shu-Ling; Graudins, Andis

doi:10.1186/s13063-019-3785-6

Cited by 15 publications

(19 citation statements)

References 52 publications

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“…neonatology 14 ); practice setting (eg pediatric intensive care 15 ); disease management (eg. acute severe asthma 16 ); and specific population‐based interventions (eg. neurological impairment and tube feeding 17 ).…”

Section: Discussionmentioning

confidence: 99%

“…Of the 599 outcomes extracted, the top three outcome domains were patient comfort (49%), clinical indicators (16%), and (19) 136 (47) 1353 (62) 293 (49) 1805 57Patient-centered outcomes (%) 6 (5) 35 (12) 251 (12) 86 (14) 378 (12) Bleeding/transfusion (%) 3 318 (6) 57(3) 32 (5) 110 3Healthcare utilization (%) 10 (8) 21 7189 (9) 60 (10) 280 (9) Clinical indicators (%) 44 3761 (21) 245 (11) 93 (16) 443 14Other (%) 34 2821 786 4 Table 6).…”

Section: Adolescents (≥13-year-olds)mentioning

confidence: 99%

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A systematic review of outcomes reported in pediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group

Muhly

Taylor

Razavi

et al. 2020

Pediatric Anesthesia

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The Pediatric Perioperative Outcomes Group (PPOG) is an international collaborative of clinical investigators and clinicians within the subspecialty of pediatric anesthesiology and perioperative care which aims to use COMET (Core Outcomes Measures in Effectiveness Trials) methodology to develop core outcome sets for infants, children, and young people that are tailored to the priorities of the pediatric surgical population. Focusing on four age-dependent patient subpopulations determined a priori for core outcome set development: (a) neonates and former preterm infants (up to 60 weeks postmenstrual age); (b) infants (>60 weeks postmenstrual age-<1 year); (c) toddlers and school age children (>1-<13 years); and (d) adolescents (>13-<18 years), we conducted a systematic review of outcomes reported in perioperative studies that include participants within age-dependent pediatric subpopulations. Our review of pediatric perioperative controlled trials published from 2008 to 2018 identified 724 articles reporting 3192 outcome measures. The proportion of published trials and the most frequently reported outcomes varied across predetermined age-groups. Outcomes related to patient comfort, particularly pain and analgesic requirement, were the most frequent domain for infants, children, and adolescents. Clinical indicators, particularly cardiorespiratory or medication-related adverse events, were the most common outcomes for neonates and infants <60 weeks and were the second most frequent domain at all other ages. Neonates and infants <60 weeks of age were significantly under-represented in perioperative trials. Patient-centered outcomes, healthcare utilization, and bleeding/transfusion-related outcomes were less often reported. In most studies, outcomes were measured in the immediate perioperative period, with the duration often restricted to the postanesthesia care unit or the first 24 postoperative hours. The outcomes identified with this systematic review will be combined with patient-centered outcomes identified through a subsequent stakeholder engagement study to arrive at a core outcome set for each age-specific group.

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Section: Discussionmentioning

confidence: 99%

Section: Adolescents (≥13-year-olds)mentioning

confidence: 99%

A systematic review of outcomes reported in pediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group

Muhly

Taylor

Razavi

et al. 2020

Pediatric Anesthesia

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“…The achievement of global recruitment into definitive RCTs represents an important milestone in PERN's development and in global pediatric emergency care research. It is expected that the current focus on interventional studies will continue, as efforts are currently underway to generate a core outcome set in acute severe pediatric asthma 28 that will serve as the basis for future RCTs in this area.…”

Section: Pern Researchmentioning

confidence: 99%

The Pediatric Emergency Research Network

et al. 2021

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Objectives The Pediatric Emergency Research Network (PERN) was launched in 2009 with the intent for existing national and regional research networks in pediatric emergency care to organize globally for the conduct of collaborative research across networks. Methods The Pediatric Emergency Research Network has grown from 5- to 8-member networks over the past decade. With an executive committee comprising representatives from all member networks, PERN plays a supportive and collaborative rather than governing role. The full impact of PERN's facilitation of international collaborative research, although somewhat difficult to quantify empirically, can be measured indirectly by the observed growth of the field, the nature of the increasingly challenging research questions now being addressed, and the collective capacity to generate and implement new knowledge in treating acutely ill and injured children. Results Beginning as a pandemic response with a high-quality retrospective case-controlled study of H1N1 influenza risk factors, PERN research has progressed to multiple observational studies and ongoing global randomized controlled trials. As a recent example, PERN has developed sufficient network infrastructure to enable the rapid initiation of a prospective observational study in response to the current coronavirus disease 2019 pandemic. In light of the ongoing need for translation of research knowledge into equitable clinical practice and to promote health equity, PERN is committed to a coordinated international effort to increase the uptake of evidence-based management of common and treatable acute conditions in all emergency department settings. Conclusions The Pediatric Emergency Research Network's successes with global research, measured by prospective observational and interventional studies, mean that the network can now move to improve its ability to promote the implementation of scientific advances into everyday clinical practice. Achieving this goal will involve focus in 4 areas: (1) expanding the capacity for global randomized controlled trials; (2) deepening the focus on implementation science; (3) increasing attention to healthcare disparities and their origins, with growing momentum toward equity; and (4) expanding PERN's global reach through addition of sites and networks from resource-restricted regions. Through these actions, PERN will be able to build on successes to face the challenges ahead and meet the needs of acutely ill and injured children throughout the world.

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“…In the United Kingdom, an asthmatic child presents in the hospitals after every 20 min. 2 Age, gender, family history and in some populations socioeconomic status are important risk factors associated with asthma. In young age, asthma is more common and even more common in male children.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Salbutamol and Salbutamol with ipratropium bromide in children with exacerbation of Asthma in terms of peak expiratory flow rate (PEFR).

Minhas¹,

Aslam

Farooq

et al. 2021

TPMJ

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Objective: To compare the Salbutamol alone and Ipratropium Bromide supplemented Salbutamol in children with exacerbation of asthma in terms of PEFR. Study Design: Randomized Controlled Trial. Setting: Pediatrics Emergency, KRL Hospital Islamabad. Period: 1st August 2016 to 31 January 2017. Material & Methods: Group A patients were given only Salbutamol (0.15mg/kg per dose with minimum 2.5 mg, maximum 5 mg/dose). Group B was given Ipratropium Bromide supplemented Salbutamol (250 mcg/dose for <20 kg while 500 mcg/dose for >20kg of Ipratropium Bromide with same dose of Salbutamol as prescribed for Group A). Baseline spirometry was performed on each patient and after measurement of baseline peak expiratory flow. The outcome was measured by Peak flow meter and reassessed at 60 minutes. Results: Comparison of salbutamol alone and ipratropium bromide supplemented salbutamol in children with exacerbation of asthma in terms of PEFR shows that 40.5 + 4.28 in Group-A and 59.5 +4.75 in Group-B, P-value was calculated as 0.0001, showing a significant difference between the two groups while the difference in increase was recorded as 19%. Conclusion: We concluded that salbutamol alone is significantly less effective when compared with Ipratropium Bromide supplemented Salbutamol in children with exacerbation of asthma in terms of PEFR.

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Acute severe paediatric asthma: study protocol for the development of a core outcome set, a Pediatric Emergency Research Networks (PERN) study

Cited by 15 publications

References 52 publications

A systematic review of outcomes reported in pediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group

A systematic review of outcomes reported in pediatric perioperative research: A report from the Pediatric Perioperative Outcomes Group

The Pediatric Emergency Research Network

Comparison of Salbutamol and Salbutamol with ipratropium bromide in children with exacerbation of Asthma in terms of peak expiratory flow rate (PEFR).

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