Acute Secondary Glaucoma Due to Spontaneous Rupture of the Lens Capsule*

Sugar, H. Saul

doi:10.1016/s0002-9394(49)90371-2

Cited by 20 publications

(7 citation statements)

References 4 publications

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“…Larger capsule tears can result in severe phacoclastic uveitis, massive fibroplasia and secondary glaucoma 9,10 . A similar situation has been described in humans 17,21,43,44 . In general, if the capsular tear exceeds 1.5 mm, removal of the lens is recommended 10 .…”

Section: Discussionmentioning

confidence: 90%

“…Lens capsule rupture may occur spontaneously as a result of penetrating trauma, in relation to specific developmental disorders, 4–8 or as an inadvertent complication of cataract surgery. While trauma is most frequently the cause of lens capsule rupture, 9,10 spontaneous lens capsule rupture has been reported in the rabbit, 11–14 mice, 7,15 rats 16 and humans 4,6,17–21 . To the authors’ knowledge this is the first report of spontaneous lens capsule rupture occurring in the canine lens as a result of lens intumescence secondary to acute onset of diabetic cataract.…”

Section: Introductionmentioning

confidence: 80%

“…While trauma is most frequently the cause of lens capsule rupture, 9,10 spontaneous lens capsule rupture has been reported in the rabbit, [11][12][13][14] mice, 7,15 rats 16 and humans. 4,6,[17][18][19][20][21] To the authors' knowledge this is the first report of spontaneous lens capsule rupture occurring in the canine lens as a result of lens intumescence secondary to acute onset of diabetic cataract. The purpose of this study is to describe diabetes mellitus-associated spontaneous lens capsule rupture in the dog and the associated clinical signs, surgical management and outcome.…”

Section: Introductionmentioning

confidence: 99%

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Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18 dogs

Wilkie

Gemensky-Metzler

Colitz

et al. 2006

Veterinary Ophthalmology

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The duration of clinical follow-up (19/20 dogs) ranged from 1 to 36 months (mean 12.9 months). All eyes that had cataract surgery with or without IOL placement were sighted at the time of the last follow-up examination. Spontaneous lens capsule rupture associated with diabetes mellitus, cataract and rapid lens intumescence occurs in the dog. Early surgical intervention, prior to secondary complications of glaucoma and loss of retinal function, is associated with a favorable outcome.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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Canine cataracts, diabetes mellitus and spontaneous lens capsule rupture: a retrospective study of 18 dogs

Wilkie

Gemensky-Metzler

Colitz

et al. 2006

Veterinary Ophthalmology

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“…Most cases of PE occur after trauma, either surgical or nonsurgical 34 . Lens capsule rupture with associated PE without any known trauma to the eye has been reported in humans, 34 –36 in dogs, 3 , 13 and in rabbits 2 , 15 . Microphthalmos was present clinically in a high percentage of humans with spontaneous lens capsule rupture 34 .…”

Section: Introductionmentioning

confidence: 99%

Lens‐induced uveitis

Woerdt

2000

Veterinary Ophthalmology

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has been described in humans and many animal species. Traumatic rupture of the lens capsule may result in vision-threatening intraocular inflammation that is poorly responsive to medical management. Phthisis bulbi, persistent uveitis or glaucoma often occurs in these eyes. Surgical removal of the lens material is generally indicated shortly after the injury in an effort to preserve vision. Leaking of lens proteins through an intact lens capsule may result in a lympho-plasmacytic anterior uveitis. This is most commonly associated with the presence of a hypermature cataract. The presence of lens-induced uveitis prior to cataract surgery significantly reduces the success rate of cataract surgery. Small amounts of circulating lens proteins maintain a normal T-cell tolerance for lens proteins. Lens-induced uveitis develops when a breakdown occurs of this normal T-cell tolerance. Immune complexes play an important role in the tissue damage associated with the ensuing inflammation. Other factors associated with the tissue damage include hydroxyl radicals, nitroxide radicals, and hydrogen peroxide and arachidonic acid metabolites. Treatment consists of topical and systemic anti-inflammatory medications, mydriatic agents, and glaucoma medications when indicated. Experimental pharmacological agents include dual cyclooxygenase/lipoxygenase inhibitors, interleukin-1 blockers, antioxidants and hydroxyl radical scavengers.

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“…Spontaneous absorption of a hypermature lens can occur rarely9 and has been attributed to a rent in the posterior lens capsule 12. Often, but not necessarily, this is associated with lens-induced uveitis or glaucoma 9.…”

Section: Discussionmentioning

confidence: 99%