Acute sacral nerve stimulation reduces visceral mechanosensitivity in Rat through spinal opioid pathway

Langlois, Ludovic D.; Méleine, Mathieu; Ouelaa, Wassila; Caremel, R.; Bridoux, Valérie; Bénard, Magalie; Déchelotte, Pierre; Ducrotté, Philippe; Grise, P.; Leroi, Anne Marie; Gourcerol, Guillaume

doi:10.1111/nmo.12555

Cited by 15 publications

(24 citation statements)

References 24 publications

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“…Incontinence is often associated with hypersensitivity and SNS has been shown to reduce C‐fibers marker substance p levels in patients’ rectal mucosa . In addition, acute SNS is able to reduce visceral sensitivity in rats . Studying the effects of SNS in models of fecal incontinence would be of great interest.…”

Section: Discussionmentioning

confidence: 99%

“…Lastly, no reliable predictive factor beyond the trial response has yet been identified for successful SNS . While several studies have identified key biological targets of SNS such as the endogenous opioid system , further delineation of the mechanisms of action of SNS is still needed.…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, small animals such as rats and mice are better characterized in terms of neuroanatomy and genetics. To date, small animal experiments have been carried out using external stimulating devices . Moreover, a limited number of studies succeeded to perform chronic SNS in rodents .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Development of a Remote-Controlled Implantable Rat Sacral Nerve Stimulation System

Langlois

Antor

Atmani

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Development of a Remote-Controlled Implantable Rat Sacral Nerve Stimulation System

Langlois

Antor

Atmani

et al. 2019

Neuromodulation: Technology at the Neural Interface

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“…Fassov J performed SNS on 21 DIARRHEA‐TYPE IBS patients and found that symptoms of some patients improved after treatment . Langlois L reported that anorectal dilatation (acute visceral hypersensitivity model) and SNS on normal SD rats could improve their visceral hypersensitivity induced by anorectal dilatation …”

Section: Introductionmentioning

confidence: 99%

“…9 Langlois L reported that anorectal dilatation (acute visceral hypersensitivity model) and SNS on normal SD rats could improve their visceral hypersensitivity induced by anorectal dilatation. 10 Nerve growth factor (NGF) is one member of the neurotrophic factor family. It is widely distributed in the central nervous system, autonomic nervous system and intestinal nervous system.…”

Section: Introductionmentioning

confidence: 99%

Effect and mechanisms of sacral nerve stimulation on visceral hypersensitivity mediated by nerve growth factor

Jiang

Wang

et al. 2019

J Cellular Molecular Medi

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To investigate the efficacy of sacral nerve stimulation (SNS) on nerve growth factor (NGF) mediated visceral sensitivity in normal rat and visceral hypersensitivity model rats. 120 male newborn rats were randomly divided into 6 groups: group A was normal model group; group B ~ F were all sensitized with acetic acid enema and grouped again. Group c2 was given NGF antagonist, d2 group was given NGF agonist, e2 group was given PI3K inhibitor, and f2 group was given PLC‐γ inhibitor. After treatment, the expression of NGF, TrKA, PI3K, AKT, PLC‐γ, NF‐κB, TRPV1, pTRPV1 and intracellular Ca2+ content were detected. The expression of protein TRPV1 and pTRPV1 was increased, and Ca2+ was increased in the visceral hypersensitive group. NGF, TrKA in NGF antagonist group, PI3K, AKT, NF‐κB in PI3K inhibitor group, PLC‐γ in PLC‐γ inhibitor group were all almost not expressed. The relative expression of NGF, TrKA, PI3K, AKT, PLC‐γ and NF‐κB in NGF antagonist group was lower than that in visceral hypersensitivity group and NGF activator group (P < .01). The relative expression of NGF, TrKA, PI3K and AKT mRNA in NGF antagonist group was lower than that in the normal model group (P < .01). There was no significant difference in the relative expression of PLC‐γ and NF‐κB mRNA (P > .05). The expression level of MAPK, ERK1 and ERK2 in visceral hypersensitivity group was higher than that in PI3K inhibitor group and PLC‐γ inhibitor group. The normal group Ca2+ curve was flat, and the NGF agonist group had the highest Ca2+ curve peak. Calcium concentration in visceral hypersensitivity group was higher than that in PI3K inhibitor group and that in PLC‐γ inhibitor group was higher than that in NGF antagonist group. The binding of TrkA receptor to NGF activates the MAPK/ERK pathway, the PI3K/Akt pathway and the PLC‐γ pathway, causing changes in the fluidity of intracellular and extracellular Ca2+, resulting in increased sensitivity of visceral tissues and organs.

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The efficacy of botulinum toxin A and sacral neuromodulation in the management of interstitial cystitis (IC)/bladder pain syndrome (BPS), what do we know? ICI‐RS 2017 think thank, Bristol

Rahnama’i

Marcelissen

Apostolidis

et al. 2018

Neurourology and Urodynamics

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Both intravesical BoNT-A treatment and SNM have been shown to have positive effects in patients with IC/BPS. However, firm conclusions cannot yet be drawn. Patient-reported outcomes and quality of life should be assessed in addition to urinary and pain symptoms. Since current treatments mainly focus on symptomatic relief, future research should also focus on clarifying the pathogenic mechanisms involved in IC/BPS.

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Acute sacral nerve stimulation reduces visceral mechanosensitivity in Rat through spinal opioid pathway

Abstract: SNS impacts on visceral mechanosensitivity by decreasing the spino-bulbar reflex in response to CRD. Spinal opioid receptors are likely involved in this effect.

Cited by 15 publications

References 24 publications

Development of a Remote-Controlled Implantable Rat Sacral Nerve Stimulation System

Development of a Remote-Controlled Implantable Rat Sacral Nerve Stimulation System

Effect and mechanisms of sacral nerve stimulation on visceral hypersensitivity mediated by nerve growth factor

The efficacy of botulinum toxin A and sacral neuromodulation in the management of interstitial cystitis (IC)/bladder pain syndrome (BPS), what do we know? ICI‐RS 2017 think thank, Bristol

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