Abstract:Acute Rheumatic fever (ARF) is the most common cause of acquired heart disease in the developing world. It is an immunological reaction to group A beta-hemolytic streptococcus Pyogenes. It occurs 2-4 weeks after group A streptococcal pharyngitis due to the development of antistreptococcal antibodies that cross-react with antigens in various tissues of the body, especially cardiac and basal ganglia neuronal antigens. Clinical features of acute rheumatic fever include fever, joint pain, myocarditis, nodules in s… Show more
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